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Prescription Required
Formulation : Solution
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Pennsaid 1.50% 60mL $100.30 Add To Cart
Pennsaid 1.50% 180mL $272.20 Add To Cart
Dosage: 1.50%
Quantity: 60mL
Price: $100.30
Dosage: 1.50%
Quantity: 180mL
Price: $272.20

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Diclofenac sodium

Prescription Required
Formulation : Solution
Drug Name Dosage Quantity Price Buy Now
Diclofenac sodium 1.50% 120ml $79.20 Add To Cart
Diclofenac sodium
Dosage: 1.50%
Quantity: 120ml
Price: $79.20


Pennsaid is a pain-relieving medication used to treat osteoarthritis pain in the knees.

Diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAID) derived from phenylacetic acid that offers both analgesic and antipyretic effects. These actions allow Pennsaid to ease pain related to osteoarthritis when applied topically to affected knee areas.

This arthritis pain medication has demonstrated similar efficacy as oral forms for relieving pain. Because Pennsaid is a topical solution, it also offers many less side effects than oral diclofenac sodium.

Uses and Dosage

The dose of Pennsaid prescribed will vary depending on the individual. Follow your doctor’s instructions carefully and read all packaging labels.

  • Clean and dry your skin before application
  • Before your first use the solution’s pump must be primed. Depress the actuation 4 times
  • Apply the smallest amount of solution needed to achieve pain relief
  • Most adults are recommended to use two pumps of the solution (40mg) twice daily
  • Massage the solution into the front, back, and sides of one affected knee and then repeat with the other
  • Wait 10 minutes before dressing and 30 minutes before bathing or showering after application
  • Do not apply Pennsaid to an open wound, infected skin, rashes, or burns
  • Do not bandage treated skin or expose it to heat from a heating pad, hot tub, or sauna
  • Store at room temperature away from moisture and heat
  • Do not let the solution freeze

Side Effects

Pennsaid may cause some side effects to develop while it relieves pain and inflammation in your knees. Speak with your doctor for more information regarding any symptoms you may encounter when using diclofenac sodium.

Common Pennsaid side effects:

  • Indigestion, gas, stomach pain, nausea, vomiting
  • Diarrhea, constipation
  • Headache, dizziness, drowsiness
  • Stuffy nose
  • Itching, increased sweating
  • Increased blood pressure
  • Swelling or pain in your arms or legs

Serious Side Effects

Some serious adverse reactions may occur when taking diclofenac sodium. Stop using this Pennsaid solution and call your doctor if you develop any of the following side effects:

  • Skin rash, no matter how mild
  • Shortness of breath
  • Swelling or rapid weight gain
  • Signs of stomach bleeding (bloody or tarry stools, coughing blood, vomit that looks like coffee grounds)
  • Liver problems (nausea, upper stomach pain, itching, tiredness, flu-like symptoms, loss of appetite, dark urine, clay-coloured stools, jaundice)
  • Troubles urinating, swelling in feet or ankles
  • Tiredness, shortness of breath
  • Severe headache, pounding in neck or ears, nosebleed, anxiety, confusion
  • Pale skin, light-headedness, shortness of breath, rapid heart rate, trouble concentrating
  • Fever, sore throat, swelling in face or tongue, burning eyes, skin pain

Allergic Reactions

Do not use Pennsaid if you are allergic to diclofenac. If you develop an allergic reaction, stop using this pain-relieving solution and contact your doctor.

Pennsaid allergy symptoms may include:

  • Sneezing, runny or stuffy nose
  • Wheezing or trouble breathing
  • Hives
  • Swelling of face, lips, tongue, or throat


Diclofenac may increase your risk of having a fatal heart attack or stroke, especially if used long term or if you have heart disease.

Pennsaid could cause stomach or intestinal bleeding, especially in older adults, and can happen without warning during treatment.

Do not use this Pennsaid solution just before or after having a heart bypass surgery.

Do not use Pennsaid if you have ever had an asthma attack or severe allergic reaction after using an NSAID such as aspirin.

Avoid getting this Pennsaid solution into your eyes, nose, or mouth. If contact does occur, rinse thoroughly with water. Call your doctor if eye irritation lasts longer than an hour.

Avoid drinking alcohol while using diclofenac because it can increase your risk of stomach bleeding.

Avoid using other NSAIDs while using Pennsaid.

To ensure your safety in taking this NSAID, tell your doctor if you have any of the following:

  • Heart disease, high blood pressure, high cholesterol, diabetes
  • If you smoke
  • History of heart attack, stroke, or blood clot
  • History of stomach ulcers or bleeding
  • Asthma
  • Liver or kidney disease
  • Fluid retention

Diclofenac can affect your ovulation and may make it harder for you to conceive while using the medication.

Consult with your doctor before using a cold, allergy, or pain medication; these types of drugs can contain aspirin or other similar medicines to Pennsaid.

Ask your doctor before taking Pennsaid if you also take an antidepressant such as citalopram, escitalopram, fluoxetine and others. Combining these medications with any NSAID can make you bruise or bleed more easily.

Some other drugs may interact with diclofenac and cause adverse reactions. Tell your doctor about all the medications you take to ensure your safety, but especially any of the following:

  • Aspiring or other NSAIDs
  • Antidepressant medications
  • Cyclosporine
  • Lithium
  • Methotrexate
  • Blood thinner
  • Heart or blood pressure medication
  • Steroid medicine

Do not use Pennsaid while pregnant unless told to do so by your doctor. Using any NSAID during the last 20 weeks of pregnancy can cause complications and serious heart or kidney problems in the unborn baby.

Avoid breastfeeding while using this medication because it is not clear whether topical diclofenac can pass into breast milk or not.

Pennsaid is not an approved pain-relieving treatment for anyone younger than the age of 18.

Form and Strength

This pain-relieving medication is available in solution form.

Pennsaid solution strength:

  • 150%

The 150% diclofenac sodium solution is available in volumes of 60 or 180mL.


What is Pennsaid used for?

Pennsaid is a topical pain medication used to relieve pain caused by osteoarthritis, specifically pain surrounding the knees. The solution uses diclofenac, a nonsteroidal anti-inflammatory drug, to provide an analgesic effect to the areas in which it is applied.

How much Pennsaid can I use each day?

Your arthritis pain treatment will vary from others as it should be individualized to you and your pain. However, the recommended dose is 2 pumps of Pennsaid solution for each knee applied once or twice each day. To avoid adverse reactions, do not use more than the dose recommended by your doctor.



Additional information

Brand Name:


Scientific Name:

Diclofenac sodium

Other Names:

Diclofenac Topical Solution, Pennsaid



Quantities Available:

60mL, 120ml, 180mL