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Prandin is a diabetes medication used to manage and control blood sugar levels in adults with type 2 diabetes mellitus.

Repaglinide is an insulin secretagogue derived from carbamoylmethyl benzoic acid that binds to beta cells to stimulate insulin release from your pancreas. The secretory effect of Prandin differs from sulfonylureas diabetes medications due to the drug’s binding site and its action on early-phase insulin. Thanks to this, Prandin helps maintain and control proper blood sugar levels for those with type 2 diabetes.

This diabetes medication is a well-tolerated and effective form of treatment for type 2 diabetes mellitus. Repaglinide is absorbed quickly and starts acting right away which helps control blood sugar levels while avoiding some adverse reactions. Prandin also follows your meal pattern rather than your eating habits having to adapt to the medication.

Uses and Dosage

The dose of Prandin that is prescribed will vary depending on the individual being treated. Follow all your doctor’s instructions and read packaging labels carefully to ensure the best therapeutic results.

  • Swallow tablet whole
  • Take doses 15 to 30 minutes before or after eating
  • Monitor blood glucose levels regularly to determine the minimum effective dose needed
  • Most adults start by taking 0.5mg with each meal if they have not previously been treated
  • Adults with previous treatment usually take an initial dose of 1 or 2mg with each meal
  • Adults are recommended to take between 0.5 and 4mg daily with meals
  • Doses may be prescribed before meals 2, 3, or 4 times daily
  • Adults should not take more than 16mg each day
  • When used to replace other hypoglycemic drugs, Prandin can be used the day after the final dose is taken
  • Prandin may be used in combination with another drug if monotherapy is not effective
  • Your doctor may prescribe a glucagon injection kit in case of severe hypoglycemia
  • Monitor for signs of low or high blood sugar
  • Discuss with your doctor before changing your dose or medication schedule
  • Store at room temperature away from children and pets

Side Effects

Prandin may cause some side effects to develop while increasing the insulin your pancreas produces. Speak with your doctor for more information regarding any side effects that may occur when taking repaglinide.

Common Prandin side effects:

  • Low blood sugar
  • Nausea, diarrhea
  • Headache, back pain
  • Joint pain
  • Cold symptoms (stuffy nose, sneezing, sore throat)

Serious Side Effects

Some more serious adverse reactions may occur when taking repaglinide. Stop using Prandin and contact your doctor if you develop any of the following symptoms:

  • Pale or yellowed skin
  • Dark coloured urine
  • Fever
  • Confusion or weakness
  • Pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting)

Allergic Reactions

Do not use Prandin if you are allergic to repaglinide. If you develop an allergic reaction, stop using this diabetes medication and contact your doctor right away.

Prandin allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, and throat
  • Fever
  • Sore throat
  • Burning eyes
  • Skin pain
  • Red or purple rash
  • Blistering or peeling skin


Prandin is a type 2 diabetes medication and is not designed to treat type 1 diabetes.

Avoid drinking alcohol while taking Prandin because it lowers your blood sugar levels and can interfere with your treatment.

Do not use Prandin if you have any of the following:

  • Type 1 diabetes
  • Severe liver disease
  • Diabetic ketoacidosis

Prandin should not be used in combination with gemfibrozil or an NPH insulin like isophane insulin.

This diabetes medication should be used alongside a complete treatment program including diet, exercise, and weight control to ensure the best blood sugar control.

To ensure your safety when taking Prandin, tell your doctor if you have ever had any of the following:

  • Liver disease
  • If you also take metformin or another diabetes medication

Some drugs may cause adverse reactions when taken with repaglinide and should not be used at the same time. To avoid this, tell your doctor about all the medications you take, including over-the-counter medicines, but especially any of the following:

  • clopidogrel
  • Cyclosporine
  • Gemfibrozil
  • NHP insulin

Consult your doctor if you are pregnant or become pregnant while using Prandin. Follow your doctor’s instructions carefully because it is important to manage diabetes during pregnancy to reduce the risk of complications caused by high blood sugar.

Do not breastfeed while taking Prandin; repaglinide can pass into breast milk and affect a nursing child.

Prandin is not an approved treatment for anyone under the age of 18 years old.

Form and Strength

This diabetes medication is available in tablet form.

Prandin tablet strengths:

  • 0.5mg
  • 1mg
  • 2mg


How long before a meal should you take Prandin?

Prandin is usually recommended to be taken within 15 minutes of eating, but your dose can be taken any time between 30 minutes and right before your meal. Your doctor may instruct you to take your doses 2, 3, or 4 times each day before eating food.

How long does it take for Prandin to start working?

Prandin is easily and readily absorbed into your system, reaching peak concentrations of repaglinide within an hour of taking your dose. This allows for a rapid onset of action that helps control your blood sugar during meals. Repaglinide has an elimination half-life of 1 hour, meaning it is quickly passed through your system so you can take multiple doses each day aligning with your meals.



Additional information

Brand Name:


Scientific Name:


Other Names:

Novonorm, Repaglinide


0.5mg, 1mg, 2mg

Quantities Available:

90, 100, 180