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Accupril is a medication classified as an ACE inhibitor, used to treat hypertension and heart failure. The active ingredient, quinapril hydrochloride, works by relaxing blood vessels and increasing blood flow.

Follow the dosing instructions provided by a healthcare professional when taking Accupril to ensure the best results.

Use and Dosage

Read the Patient Information Leaflet if available from your pharmacist before you start taking quinapril and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once or twice a day. High-fat meals may decrease the absorption of this medication.

To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

The dosage is based on your medical condition and response to treatment.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

For the treatment of high blood pressure, it may take 1 to 2 weeks before you get the full benefit of this medication. For the treatment of heart failure, it may take weeks to months before you get the full benefit of this medication.

This product contains magnesium which may interfere with the absorption of some medications. See the Drug Interactions section and consult your pharmacist for more information.

Tell your doctor if your condition does not get better or if it gets worse (for example, your blood pressure readings remain high or increase).

Side Effects

Common side effects include:

  • Nausea
  • Headache
  • Lightheadedness
  • Dizziness
  • Tiredness or fatigue
  • Stomach discomfort
  • Dry cough
  • Vomiting

In most cases, the side effects caused by this drug are mild and short-term. If these adverse reactions persist or worsen, it may be necessary to hold medication for a while and consult your doctor or any healthcare provider.

Severe side effects include:

  • High potassium level in the blood or hyperkalemia (muscle weakness, slow heartbeat)
  • Fainting
  • Changes in urine output
  • Persistent nausea and vomiting
  • Loss of appetite
  • Severe stomach pain
  • Yellowish eyes or skin
  • Dark urine

This is not a complete list of Accupril’s side effects.


You should not use Accupril if you are allergic to quinapril, or if:

  • You have a history of angioedema
  • You recently took a heart medicine called sacubitril
  • If you are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, ramipril, or trandolapril

Do not take Accupril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use Accupril together with any medication that contains Aliskiren (such as Tekturna or Tekamlo).

You may need to avoid taking quinapril with Aliskiren if you have kidney disease.

To make sure Accupril is safe for you, tell your doctor if you have ever had:

  • Kidney disease (or if you are on dialysis)
  • Liver disease
  • A connective tissue disease such as Marfan syndrome, Sjogren’s syndrome, lupus, scleroderma, or rheumatoid arthritis
  • Heart disease or congestive heart failure (unless you are taking quinapril for this condition)
  • If you are on a low-salt diet

Do not use it if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Quinapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

It may not be safe to breastfeed while using quinapril. Ask your doctor about any risks.

Accupril is not approved for use by anyone younger than 18 years old.

Form and Strengths

  • Accupril Tablet:
    • 5 mg
    • 10 mg
    • 40 mg
  • Quinapril Tablet:
    • 10 mg
    • 20 mg


What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up for the missed dose.

What happens if I overdose?

Seek emergency medical attention.

What to avoid?

Do not use salt substitutes or potassium supplements while taking Accupril unless your doctor has told you to.



Additional information

Brand Name:

AccupriL, Accupril

Scientific Name:


Other Names:

Acuitel, Quinapril


5mg, 10mg, 20mg, 40mg

Quantities Available:

84, 90, 100