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Aciphex is an antacid medication used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions relating to excess stomach acid. This medication also helps encourage healing of duodenal ulcers or erosive esophagitis.

Rabeprazole is a proton pump inhibitor that reduces stomach acid production by inducing the secretion of gastric acid. This mechanism allows Aciphex to treat and prevent conditions related to excessive stomach acid.

Uses and Dosage

The dose of Aciphex prescribed will depend on the individual and condition being treated. Always follow your doctor’s instructions and read packaging labels carefully.

  • Swallow tablets whole
  • For duodenal ulcer treatment, take after a meal
  • For other conditions, take with or without food
  • Most adults take 20mg once daily
  • Most treatments last 4 to 8 weeks
  • Do not take two doses at once
  • Take Aciphex for the entire length of time prescribed
  • Store at room temperature away from moisture and heat

Side Effects

Aciphex may cause some side effects to develop while it decreases your production of stomach acid. Speak with your doctor for more information regarding any symptoms you may encounter when taking rabeprazole.

Common Aciphex side effects:

  • Infection
  • Pain
  • Sore throat
  • Headache
  • Nausea, vomiting
  • Gas, diarrhea, constipation
  • Stomach pain

Serious Side Effects

Some more serious side effects may occur when taking Aciphex. Stop taking this antacid and contact your doctor if you notice any of the following symptoms:

  • Severe stomach pain
  • Watery or bloody diarrhea
  • Sudden pain or trouble moving hip, wrist, or back
  • Seizure
  • Kidney problems (fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, swelling, rapid weight gain)
  • New or worsening lupus symptoms (joint pain, skin rash on cheeks or arms that worsens in sunlight)
  • Low magnesium levels (dizziness, fast or irregular heart rate, tremors or jerking muscle movements, feeling jittery, muscle cramps, muscle spasms in hands and feet, cough or choking feeling)
  • If you also take warfarin, signs of bleeding (headaches, dizziness, weakness, pain or swelling, bruising or unusual bleeding, red or pink urine, heavy menstrual flow, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, bleeding that won’t stop)

Allergic Reactions

Do not take Aciphex if you are allergic to rabeprazole or similar medications such as lansoprazole, esomeprazole, omeprazole, or pantoprazole. If you develop an allergic reaction, stop taking this medication and see your doctor right away.

Aciphex allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


Heartburn can mimic early heart attack symptoms. Seek immediate medical attention if you develop chest pain that spreads to your jaw or shoulder and if you feel anxious or light-headed.

Aciphex is not designed to provide immediate heartburn relief.

Do not use Aciphex if you take medicine containing rilpivirine or if you have any of the following:

  • Breathing problems
  • Kidney problems
  • Severe allergic reaction after taking rabeprazole

To ensure the safety of taking this antacid medication, tell your doctor if you have ever had any of the following:

  • Liver disease
  • Osteoporosis or low bone mineral density
  • Lupus
  • Low levels of magnesium

Rabeprazole may cause problems with your kidney. Tell your doctor if you notice you are urinating less than usual or have blood in your urine.

Call your doctor right away if you have bloody or watery diarrhea, this could be a sign of a new infection.

Aciphex may cause new or worsening symptoms of lupus. Contact your doctor if you develop joint pain with a rash on your cheeks or arms that worsens under sunlight.

Taking Aciphex long term or more than once per day may increase your risk of bone fracture in your hip, wrist, or spine.

Some other medications may interact with rabeprazole and cause adverse reactions. Tell your doctor about all the medications you take, including over the counter medicine, vitamins, and herbal products, but especially the following:

  • Antibiotics
  • Digoxin
  • Diuretic
  • Methotrexate
  • warfarin

Tell your doctor if you are pregnant or breastfeeding to ensure the safety of you and your child.

Do not give Aciphex to anyone younger than 12 years old without first speaking to your doctor. Certain forms and strengths of rabeprazole should not be given to children.

Form and Strength

This antacid medication is available as a delayed release tablet.

Aciphex tablet strengths:

  • 10mg
  • 20mg

The 10mg tablets are available in quantities of 28, 84, or 100 while the 20mg tablets are available in quantities of 90 or 100.


How does Aciphex work?

Aciphex is a proton pump inhibitor that helps treat heartburn, stomach ulcers, gastroesophageal reflux disease, and esophageal damage. The medication does this by inhibiting your body’s production of stomach acid. Thanks to this action, Aciphex can also treat conditions caused by excess stomach acid such as Zollinger-Ellison syndrome.

What are the side effects of Aciphex?

Aciphex can cause some side effects while it reduces your stomach acid production. Common symptoms include a rash or itching, upset stomach, diarrhea, gas, sore throat, headache, insomnia, or anxiousness. There are also some more serious side effects that are less common but may develop, such as liver damage or dizziness.



Additional information

Brand Name:


Scientific Name:


Other Names:

Pariet, Parit, Rabeprazole, Rabesec, Rabicip


10mg, 20mg

Quantities Available:

28, 84, 90, 100, 180


Delayed Release Tablet, Delayed Release Tablet (Enteric Coated), Tablet