Formulation : Capsule
Dosage : 300mg/0.5mg
Quantity : 1
Prescription Required
(All Prices in USD)


Akynzeo is a prescription medicine used to prevent nausea (feeling sick) and vomiting in adults with cancer who are receiving chemotherapy (medicines to treat cancer).

Akynzeo is a combination of two medications: netupitant and palonosetron. Netupitant works by blocking the action of a substance in the brain called substance P, while palonosetron works by blocking the action of a different substance called serotonin. Together they work to reduce the likelihood of chemotherapy-induced nausea and vomiting (CINV).

Use and Dosage

The dosage is dependent on the age, weight, and health of the individual. Akynzeo is available in both capsule and injection forms.

For adults, the recommended dosage is one capsule taken orally, 60 minutes before the start of chemotherapy. It can be taken with or without food. For individuals with moderate to severe liver disease, a lower dosage may be recommended.

Follow the instructions of a healthcare provider when taking Akynzeo or any prescription medication.

Side Effects

Serious side effects of Akynzeo include:

Along with its needed effects, netupitant/palonosetron may cause some unwanted effects. Although not all these side effects may occur, if they do occur, they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking netupitant / palonosetron:

  • Incidence not known
    • Agitation
    • Confusion
    • Dizziness
    • Fever
    • Hearing or seeing things that are not there
    • Muscle twitching
    • Overactive reflexes
    • Poor coordination
    • Shivering
    • Sweating
    • Trembling or shaking

Other side effects of Akynzeo:

Some side effects of netupitant / palonosetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your healthcare professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

  • More common
    • Headache
    • Fatigue
    • Unusual tiredness or weakness
  • Less common
    • Constipation
    • Flushing or redness of the skin
    • Heartburn
    • Indigestion
    • Stomach discomfort, upset, or pain


Before taking this product, tell your doctor or pharmacist if you are allergic to netupitant or palonosetron; or to other anti-nausea serotonin blockers (such as ondansetron); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of kidney disease and liver disease.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.

It is unknown if this product passes into breast milk. Consult your doctor before breastfeeding.

Form and Strengths

Akynzeo is available in the following form and strengths:

Akynzeo Capsule:

  • 300 mg/0.5 mg


What is Akynzeo used for?

Akynzeo is used to prevent nausea and vomiting in adults with cancer who are receiving chemotherapy.

What should I do if I miss a dose of Akynzeo?

If you miss a dose of Akynzeo, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Can Akynzeo interact with other medications?

Yes, Akynzeo may interact with certain medications, including some antibiotics and medications for an irregular heartbeat. It is important to inform your healthcare provider of all medications you are taking before starting Akynzeo.


  1. https://www.webmd.com/drugs/2/drug-167114/akynzeo-netupitant-oral/details
  2. https://medlineplus.gov/druginfo/meds/a614053.html
  3. https://www.drugs.com/sfx/akynzeo-side-effects.html#serious-side-effects

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