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Aldactone is a diuretic water pill used to treat hypertension or hypokalemia as well as fluid retention in people with congestive heart failure, cirrhosis of the liver, or the kidney disorder nephrotic syndrome.

Spironolactone is an aldosterone antagonist that helps reduce and prevent fluid retention while maintaining the body’s potassium levels. The drug does this by binding aldosterone-controlled sodium-potassium exchange receptors to increase the excretion of sodium and water without losing potassium.

This diuretic is approved to help manage edema and reduce the risk of death for those with heart failure. Aldactone may also help lower blood pressure for those with hypertension that other agents can’t control. Thanks to spironolactone’s ability to increase water and sodium secretion, this medication also helps treat edema related to multiple conditions.

Uses and Dosage

The dose of Aldactone that is prescribed will vary depending on the individual and condition being treated. Always follow your doctor’s instructions and read packaging labels carefully.

  • Take with or without food but stay consistent
  • Swallow tablets whole
  • For heart failure, most start by taking 25mg once daily
  • Adults should not take more than 100mg daily for heart failure
  • For hypertension, adults take between 25 and 100mg daily
  • For edema, most take an initial dose of 100mg daily
  • Long term treatment of edema ranges from 25 to 200mg daily
  • Tell a surgeon you take Aldactone before surgery, you may need to stop for a short time
  • If using for high blood pressure, continue taking Aldactone even if you feel well
  • Store at room temperature away from light and moisture

Side Effects

Aldactone may cause some side effects to develop as it increases your water and sodium secretion. Speak with your doctor for more information regarding any symptoms you may encounter when taking spironolactone.

Common Aldactone side effects:

  • Breast swelling or tenderness

Serious Side Effects

Some more serious side effects may occur when taking Aldactone. If you notice any of the following symptoms, stop taking this medication and contact your doctor:

  • Light-headed feeling, like you might pass out
  • Little or no urination
  • High potassium levels (nausea, weakness, tingling, chest pain, irregular heartbeats, loss of movement)
  • Electrolyte imbalance (increased thirst or urination, confusion, vomiting, muscle pain, slurred speech, severe weakness, numbness, loss of coordination, feeling unsteady)

Allergic Reactions

Do not take Aldactone if you are allergic to spironolactone. Stop taking this medication and contact your doctor if you develop signs of an allergic reaction.

Aldactone allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


Avoid drinking alcohol when taking Aldactone because this can increase adverse effects.

Do not use potassium supplements or salt substitutes when using Aldactone unless directed to do so by a doctor.

Avoid following a high salt diet because excess sodium can cause your body to retain more water which could cause this medication to lose effectiveness.

Be careful when driving or performing any activity that requires alertness while taking Aldactone because it can affect your reactions.

Be careful when taking Aldactone if you have kidney problems, high potassium levels, Addison’s disease, or if you are unable to urinate, or are also taking eplerenone.

Do not use Aldactone for any conditions that have not been checked with your doctor. Spironolactone has caused tumors in animals but this effect in people is uncertain.

To ensure the safety of taking Aldactone, tell your doctor if you have any of the following:

  • An electrolyte imbalance
  • Kidney disease
  • Liver disease
  • Heart disease

Consult with your doctor before taking opioid medication, a sleeping pill, muscle relaxer, or medication for anxiety, depression, or seizures. Spironolactone can cause drowsiness, an effect that can worsen when taken with similar acting drugs.

Tell your doctor about all the medications you take, including over the counter medication, vitamins, and herbal products, but especially the following:

  • Colchicine
  • Digoxin
  • Lithium
  • Loperamide
  • Trimethoprim
  • Heart or blood pressure medicine
  • Blood clot medicine
  • Nonsteroidal anti-inflammatory drugs

Consult with your doctor if you are pregnant or plan to become pregnant while taking Aldactone to create a treatment plan. This medication may not be safe to take when breastfeeding.

Form and Strength

This diuretic is available in tablet form.

Aldactone tablet strengths:

  • 25mg
  • 50mg
  • 100mg

The 25mg tablets are available in quantities of 45 and 90 while the 50mg ones are available in quantities of 90 and the 100mg tablets are available in groups of 100.


How does Aldactone work?

Aldactone is a diuretic medication that helps decrease water retention and treat heart failure, hypertension, or hypokalemia. Spironolactone blocks aldosterone in a part of your kidneys so you secrete more water and salt when you urinate.

What food or drink should I avoid while taking Aldactone?

Do not use low-sodium salt or salt substitutes because they contain high levels of potassium which, in combination with Aldactone, can cause you to have too much potassium in your system. You should also avoid frequently eating foods and drinks that are high in potassium.



Additional information

Brand Name:


Scientific Name:


Other Names:

Aldactone, Spironolactone


25mg, 50mg, 100mg

Quantities Available:

90, 100


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