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Avelox is an antibiotic medication used to treat bacterial sinusitis, bacterial exacerbations of chronic bronchitis, and community acquired pneumonia.

Moxifloxacin is a fluoroquinolone antimicrobial drug that fights common community acquired respiratory and atypical pathogens that lead to infections. Avelox fights these infections by inhibiting the topoisomerase II and IV which stops bacteria from duplicating and spreading.

This antibiotic is well-tolerated with minimal serious adverse effects. Studies have shown Avelox to be more effective than penicillin and other antibiotics for treating certain infections while also having a lower incidence of bacterial resistance.

Uses and Dosage

The dose of Avelox prescribed will vary depending on the individual and infection being treated. Always follow your doctor’s directives and read packaging instructions carefully when taking new medications.

  • Swallow tablets whole
  • Take with or without food
  • Take doses with a glass of water; stay hydrated to maintain kidney function
  • Most adults take 400mg once daily
  • Take Avelox once every 24 hours
  • Use this antibiotic for the full time prescribed, even if your symptoms subside
  • Do not share Avelox with anyone else
  • Store at room temperature away from heat and moisture

Side Effects

Avelox may cause some side effects to develop while it fights bacterial infections in your body. Speak with your doctor to learn more specifics about symptoms you may encounter when taking moxifloxacin.

Common Avelox side effects:

  • Nausea, diarrhea
  • Dizziness
  • headache

Serious Side Effects

Some more serious side effects may occur when taking moxifloxacin. If you notice any of the following symptoms, stop using Avelox and contact your doctor right away:

  • Low blood sugar (headache, hunger, sweating, irritability, dizziness, nausea, fast heartbeats, feeling anxious or shaky)
  • Numbness, weakness, tingling, or burning pain in your hands, arms, legs, or feet
  • Changes in mood or behaviour (nervousness, confusion, agitation, paranoia, hallucinations, memory problems, trouble concentrating, suicidal thoughts)
  • Tendon rupture (sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in your joints)
  • Severe stomach pain, watery or bloody diarrhea
  • Fast or pounding heartbeats, shortness of breath, sudden dizziness
  • Muscle weakness, trouble breathing
  • Seizures
  • Skin rash
  • Increased pressure inside your skull (migraines, ringing in your ears, vision problems, pain behind your eyes)
  • Liver problems (upper stomach pain, loss of appetite, dark urine, clay-coloured stools, jaundice)

In rare instances, Avelox may damage your aorta, your body’s main artery, which can lead to dangerous bleeding or death. Seek immediate medical attention if you develop severe and constant pain in your chest, stomach, or back.

Allergic Reactions

Do not take Avelox if you are allergic to moxifloxacin or other fluoroquinolones such as ciprofloxacin, gemifloxacin, or levofloxacin. Stop using this medication and contact your doctor if you develop signs of an allergic reaction.

Avelox allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling in face, tongue, lips, or throat
  • Fever
  • Sore throat
  • Burning eyes
  • Skin pain
  • Red or purple rash
  • Blistering or peeling skin


This antibiotic may cause serious side effects, including issues with your tendons, nerve damage, serious changes in mood or behaviour, and low blood sugar.

While rare, moxifloxacin may damage your main artery which could lead to dangerous bleeding or death. Seek immediate medical attention if you have constant, severe pain in your chest, stomach, or back.

Avelox can cause your tendons to swell or tear, especially in your Achilles’ tendon. This damage can occur during treatment or several months after your last dose. These side effects are more likely to occur in patients aged 60 and older, those taking steroid medication, or those who have had a kidney, heart, or lung transplant.

To ensure the safety of taking this medication, tell your doctor if you have ever had any of the following:

  • Arthritis or problems with your tendons, bones, or joints
  • Poor blood circulation, aneurysms, narrowing or hardening of the arteries
  • Heart problems or high blood pressure
  • A genetic disease such as Marfan syndrome or Ehler’s-Danlos syndrome
  • Diabetes
  • Muscle or nerve disorder
  • Liver or kidney disease
  • Seizure, head injury, or brain tumour
  • Long QT syndrome (in yourself or a family member)
  • Low potassium levels

Avoid driving or performing activities that require alertness until you know how this medication will affect you because Avelox can impair your thinking or reactions.

Antibiotics, including Avelox, can cause diarrhea which may be a sign of a new infection. Call your doctor if you have watery or bloody diarrhea before using any anti-diarrhea medicine.

Avoid direct exposure to sunlight and do not use tanning beds while taking moxifloxacin because it can make your skin more susceptible to burning. Wear protective clothing and use sunscreen when spending time outside. Tell your doctor if you notice you have severe burning, redness, itching, or swelling after being out in the sun.

Some other drugs may interact with Avelox and cause unwanted side effects. Tell your doctor about all the medications you take, including over the counter medicines, vitamins, and herbal products, but especially the following:

  • Erythromycin
  • Blood thinners
  • Diuretics
  • Heart rhythm medication
  • Insulin or oral diabetes medication
  • Medicine for depression or mental illness
  • Steroid medication
  • Non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen, and others)

Certain drugs cause moxifloxacin to lose efficacy when taken at the same time. Take your dose of Avelox 4 hours before or 8 hours after other medications, especially any of the following:

  • Ulcer medicine or antacids that contain calcium, magnesium, or aluminum
  • Didanosine powder or chewable tablets
  • Lanthanum carbonate or sevelamer
  • Vitamin or mineral supplements that contain aluminum, iron, magnesium or zinc

Avelox is not an approved treatment for anyone younger than 18 years of age.

Tell your doctor if you are pregnant or breastfeeding to ensure the safety of you and your child.

Form and Strength

This antibiotic medication is available in tablet form.

Avelox tablet strength:

  • 400mg

The 400mg Avelox tablets are available in quantities of 30, 84, or 90.


Is Avelox a form of penicillin?

No, Avelox contains moxifloxacin which is in the class of antibiotics called fluoroquinolones while penicillin is in the Penicillin class. The two antibiotics function slightly differently. Studies have shown that moxifloxacin is the more active against pneumococci than penicillin and some other types of antibiotics.

What kind of infections does Avelox treat?

Avelox uses moxifloxacin to fight bacteria and treat various bacterial infections. This extended-spectrum fluoroquinolone antibiotic kills and inhibits the spread of upper and lower respiratory tract pathogens, especially pneumococci. These actions allow Avelox to treat pneumonia, acute bacterial sinusitis, and chronic bronchitis with bacterial infection.



Additional information

Brand Name:


Scientific Name:


Other Names:

Avelox, Moxifloxacin



Quantities Available:

30, 84, 90