Safely Buy Combipatch ( Estradiol 17b/Norethindrone Acetate ) from Canada Prescriptions Plus.


CombiPatch is a combination transdermal hormone therapy patch containing both estrogen and progestin designed specifically for postmenopausal women.

CombiPatch is used to reduce symptoms of menopause, such as hot flashes, vaginal dryness, and mood swings.

Use and Dosage

Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Peel off the backing from the patch and apply the patch to a clean, dry area of the lower stomach. Press the patch firmly in place for about 10 seconds to make sure it stays on. Do not apply the patch on the breast or oily, broken, or irritated skin. Avoid applying the patch to areas of the skin where it might be easily rubbed off (such as the waistline). When wearing the patch, do not expose it to the sun for long periods. Use this medication as directed by your doctor. The patch is usually replaced twice a week (every 3 to 4 days). Follow the dosing schedule carefully.

The dosage is based on your medical condition and response to treatment.

When replacing your patch, make sure to apply the new patch to a different area. Wait at least 1 week before applying a patch to the same area. Fold the old patch in half with the sticky side together and throw it away in the trash away from children and pets. Do not flush the patch down the toilet.

If a patch falls off, reapply it to a different area. If the patch does not stick completely, then apply a new patch and wear it for the rest of the scheduled period. Do not wear 2 patches at the same time.

Use this medication regularly to get the most benefit from it. To help you remember, change the patch on the same days each week. It may help to mark your calendar with a reminder.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Common side effects include:

  • Nausea
  • Headache
  • Weakness
  • Vomiting
  • Redness or irritation on the application site
  • Abdominal pain
  • Breast tenderness
  • Back pain
  • Weight changes
  • Dark patches on the face

In most cases, the side effects brought about by this treatment are mild and temporary. If the adverse reactions get worse or do not resolve, you may have to hold the medication for a while and consult your doctor or healthcare professional.

Severe side effects include:

  • Mental or mood changes
  • Breast lumps
  • Unusual vaginal bleeding
  • Increased vaginal irritation
  • Unusual vaginal odour or discharge
  • Swelling of the extremities
  • Increased thirst or urination
  • Blood clots

This is not a complete list of the side effects of CombiPatch.


Before using this medication, tell your doctor or pharmacist if you are allergic to estradiol or norethindrone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: vaginal bleeding of unknown cause, certain cancers (such as breast cancer, cancer of the uterus/ovaries), blood clots, stroke, heart disease (such as heart attack), liver disease, kidney disease, family medical history (especially breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), blood clotting disorders (such as protein C or protein S deficiency), high blood pressure, diabetes, high blood cholesterol/triglyceride levels, obesity, lupus, underactive thyroid (hypothyroidism), mineral imbalance (low or high level of calcium in the blood), a certain hormone problem (hypoparathyroidism), uterus problems (such as fibroids, endometriosis), gallbladder disease, asthma, seizures, migraine headaches, a certain blood disorder (porphyria), mental/mood disorders (such as dementia, depression).

Do not smoke or use tobacco. Estrogens combined with smoking further increase your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35.

Tell your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time (such as a long plane flight). These conditions increase your risk of getting blood clots, especially if you are using an estrogen product. You may need to stop this medication for a time or take special precautions.

This medication may cause blotchy, dark areas on your face and skin (melasma). Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.

If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Consult your eye doctor if these problems occur.

If you are going to have an MRI test, tell testing personnel that you are using this patch. Some patches may contain metals that can cause serious burns during an MRI. Ask your doctor whether you will need to remove your patch before the test and apply a new patch afterward, and how to do so properly.

Older adults may be more sensitive to the side effects of this drug, especially the increased risk of stroke, breast cancer, and dementia.

This medication should not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor right away.

This medication passes into breast milk. It may reduce the quality and amount of breast milk produced. Consult your doctor before breastfeeding.

Form and Strengths

Combipatch is available in the following form and strengths:

Combipatch Patch:

  • 0.05/0.14 mg
  • 0.05/0.25 mg


Can I cut Combipatch in half?

You must not cut or split this patch in half.

Does Combipatch cause weight gain?

This prescription medication may cause weight gain.

What should I do if the skin patch falls off?

If the patch falls off, reapply it in the area. If it does not stick, apply a new patch.

How should I dispose of my patch?

After removing your patch, fold it with the sticky side together and throw it away accordingly. Do not flush it in the toilet.



Additional information

Brand Name:


Scientific Name:

Estradiol 17b/Norethindrone Acetate

Other Names:

Estalis Continuous


0.05/0.14mg, 0.05/0.25mg

Quantities Available:

8, 24