Safely Buy Divigel ( Estradiol Gel ) from Canada Prescriptions Plus.

We don't sell this generic-version medication.

( Top Brand Option )


Prescription Required
Formulation : Gel Sachet
Drug Name Dosage Quantity Price Buy Now
Divigel 0.5mg 30 sachets $47.60 Add To Cart
Divigel 0.5mg 90 sachets $107.10 Add To Cart
Divigel 0.25mg 90 sachets $113.30 Add To Cart
Divigel 1mg 30 sachets $47.00 Add To Cart
Divigel 1mg 90 sachets $106.70 Add To Cart
Dosage: 0.5mg
Quantity: 30 sachets
Price: $47.60
Dosage: 0.5mg
Quantity: 90 sachets
Price: $107.10
Dosage: 0.25mg
Quantity: 90 sachets
Price: $113.30
Dosage: 1mg
Quantity: 30 sachets
Price: $47.00
Dosage: 1mg
Quantity: 90 sachets
Price: $106.70


Divigel is an estrogen hormone therapy medication used to treat moderate to severe vasomotor symptoms (hot flashes and night sweats) due to menopause.

Divigel is an estradiol gel that is absorbed through the skin and enters the bloodstream. It is used by women to help reduce menopausal symptoms such as hot flashes and night sweats.

Use and Dosage

Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. Learn how to apply the gel correctly. If you have any questions, ask your doctor or pharmacist.

Apply the medication to clean, dry skin on the upper thigh area as directed by your doctor, usually once daily. Switch between the right and left thighs with each application. Avoid applying this medication to broken, irritated skin. Do not apply this medication to the breast, face, or in or around the vagina. Do not let others apply this medication to your body.

The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this medication more often than prescribed.

After applying this medication, wash your hands thoroughly with soap and water to reduce the risk of accidentally spreading it from your hands to other people. Wait a few minutes for the application site to dry completely before dressing. Cover the application site with clothing (such as shorts or pants) to prevent others from touching the application area and being exposed to the drug. Wait at least 1 hour before allowing others to touch the skin where the medication was applied. If someone accidentally touches the gel (or the application area within 1 hour), have them wash the area of contact on their body with soap and water as soon as possible.

To get the best effect, wait at least 1 hour before showering/swimming to allow the drug to be absorbed through the skin.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.

Avoid getting this medication in the eyes. If this medication gets in the eyes, rinse them right away with warm water. Tell your doctor if you get any eye irritation.

This medication is flammable until dry. Let the gel dry before smoking or going near an open flame.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Common side effects:

  • Nausea
  • Dizziness
  • Headache
  • Vomiting
  • Bloating
  • Loss of appetite
  • Swollen breast
  • Acne or skin discoloration
  • Weight changes

Mostly, the side effects caused by this medication are mild and short-term. If the adverse reactions aggravate or do not resolve after a while, you must hold this medication and call your doctor or any healthcare professional.

Severe side effects, including:

  • Increased vaginal irritation
  • Unusual vaginal bleeding
  • Breast lumps
  • Severe abdominal pain
  • Persistent nausea and vomiting
  • Dark urine
  • Mental or mood changes
  • Signs of blood clots (chest pain, trouble breathing, coughing out blood, slurred speech, sudden dizziness, severe headache, vision changes, confusion)

This is not a complete list of the side effects of Divigel.


Before you begin using this topical drug, you must disclose your complete medical history to your physician, including any history of blood clots, stroke, heart attack, certain cancers, vaginal bleeding of unknown causes, uterus problems, gallbladder disease, angioedema, hypothyroidism, hypoparathyroidism, mineral imbalance, liver disease, seizures, migraine, porphyria, or mental and mood disorders. Some conditions may affect how your system will respond to the treatment. Moreover, you should talk about all the prescription drugs and nonprescription drugs you are taking because of the possible drug interactions with estradiol.

Be watchful for an allergic reaction while using this gel. Avoid using this topical agent if you have a known allergy to estradiol or any inactive ingredients the gel may contain. Discontinue medication and immediately seek emergency help once you experience signs of hypersensitivity response which include skin rashes, itchiness, swelling of the face and neck, severe dizziness, and trouble breathing.

Avoid smoking, using tobacco, or any similar substances that may contain nicotine. This certain substance could increase the risk of high blood pressure, blood clots, heart attack, and stroke, especially among women 35 years of age and older.

Consult your healthcare provider if you will be confined in a certain position for an extended period. This includes going on long-haul flights or going through surgery. This is because limited movements could also increase the risk of blood clot formation.

This medication may cause dark and blotchy patches on the face or skin called melasma. This skin condition could be worsened by sun exposure. Limit your time under the sun and avoid indoor tanning. You should also apply sunblock cream and wear protective clothing when going outdoors.

Form and Strengths

Divigel is available in the following form and strengths:

  • Divigel Gel Sachet:
    • 0.25 mg
    • 0.5 mg
    • 1 mg


Can I use this medication for anxiety?

The link between Divigel and anxiety is based on the mental changes that may be caused by this medication.

Does Divigel help with weight loss?

This medication could cause weight changes.

What is the difference between Divigel & Estrogel?

On Divigel vs Estrogel, the former addresses vasomotor symptoms while the latter could treat both vasomotor and vaginal symptoms.



Additional information

Brand Name:


Scientific Name:

Estradiol Gel

Other Names:



0.5mg, 0.25mg, 1mg

Quantities Available:

30 sachets, 90 sachets


Gel Sachet