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Formulation : Tablet
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Eldepryl is a medication used to treat movement disorders caused by Parkinson’s disease.

Eldepryl is a monoamine oxidase-B inhibitor and prevents the breakdown of dopamine in the brain, which is associated with Parkinson’s disease.

Eldepryl does not cure Parkinson’s, but it may improve shakiness and movement problems.

Eldepryl is also known as selegiline hydrochloride and is available in tablet form. In addition, Eldepryl may be used alone in early Parkinson’s disease or combination with other medications in the later stages of the disease.

Use and Dosage

Take this medication by mouth as directed by your doctor, usually twice daily with breakfast and lunch. Taking selegiline late in the day may cause trouble sleeping. The dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than directed.

After you have been taking selegiline for 2 or 3 days, your doctor may direct you to lower your levodopa dose. Follow your doctor’s instructions closely. Do not stop or change the dose of any of your medications without first talking with your doctor.

It may take a few weeks for the full benefits of the drug to be noticed. Do not stop taking this drug without first consulting your doctor. Talk with your doctor if the medication stops working well or if your condition worsens.

Side Effects

Get emergency medical help if you have signs of an allergic reaction to Eldepryl: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • A light-headed feeling, like you might pass out
  • Trouble breathing
  • Confusion, hallucinations, or unusual thoughts or behavior
  • Increased tremors or uncontrolled muscle movements
  • Worsening side effects of your other medications
  • High levels of serotonin in the body (when taken with an antidepressant) – agitation, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; or dangerously high blood pressure – severe headache, blurred vision, pounding in your neck or ears, anxiety, nausea, vomiting, severe chest pain, shortness of breath, pounding heartbeats, or seizure (convulsions)

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

Common Eldepryl side effects may include:

  • Dizziness
  • Nausea, stomach pain, or constipation
  • Skin rash or other irritation
  • Sleep problems (insomnia)

This is not a complete list of side effects and others may occur.


Before taking selegiline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain kind of adrenal gland tumour (pheochromocytoma), cerebrovascular disease (such as stroke), heart problems (such as congestive heart failure, heart attack), bleeding problems, history of severe/frequent headaches, peptic ulcer, diabetes, personal/family history of mental/mood disorders (such as schizophrenia, bipolar disorder), personal/family history of high blood pressure, liver disease, overactive thyroid (hyperthyroidism).

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may need to stop taking selegiline before surgery. Follow your doctor’s instructions carefully.

During pregnancy, selegiline should be used only when needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breastfeeding is not recommended while using this drug and for 7 days after the last dose. Consult your doctor before breastfeeding.

Form and Strengths

Eldepryl is available in the following form and strengths:

  • Eldepryl Tablet:
    • 5 mg
    • 10 mg
  • Selegiline Tablet:
    • 5 mg


What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose.

Do not take extra medicine to make up for the missed dose.

What happens if I overdose?

Seek emergency medical attention.

Overdose symptoms may include severe headache, hallucinations, vision problems, sweating, cool or clammy skin, fast or uneven heart rate, feeling light-headed, fainting, or seizure (convulsions).

What to avoid?

Avoid drinking alcohol while you are taking Eldepryl.

While taking Eldepryl and for 14 days after you stop, you must NOT eat foods that are high in tyramine.



Additional information

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Other Names:

Eldepryl, Selegiline


5mg, 10mg

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