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Indications

Emend (aprepitant) is a prescription medication used to prevent nausea and vomiting associated with cancer chemotherapy and surgery. It is indicated for the treatment of:

• Prevention of acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy regimens in combination with other antiemetic agents in adults and children 6 months and older.
• Prevention of acute nausea and vomiting associated with moderately emetogenic cancer chemotherapy regimens in combination with other antiemetic agents in adults.
• Prevention of delayed nausea and vomiting associated with moderately emetogenic cancer chemotherapy regimens in adults.

Use and Dosage

Dosage and administration of Emend are determined based on the chemotherapy regimen being used, the patient’s age and medical history, and other factors. That is significant to consult with your healthcare provider regarding the appropriate use of Emend.

Side Effects

Common side effects include:

• Nausea
• Headache
• Dizziness
• Tiredness
• Hiccups
• Heartburn
• Loss of appetite
• Insomnia or trouble sleeping

Mostly, the side effects brought about by this antiemetic agent are mild and will resolve even without intervention. If the adverse reactions persist or worsen, it may be necessary to hold the medication and consult your doctor or any healthcare provider.

Severe side effects include:

• Severe abdominal pain
• Fainting
• Fever
• Chills
• Body aches
• Increased thirst
• Unable to urinate
• Heavy sweating

This is not a complete list of Emend’s side effects.

Cautions

Before starting to use this oral drug, you should disclose your full medical history to your physician. This includes any history of liver disease or kidney disease. Certain conditions or disorders may have an impact on how your body will respond to Emend. In addition, you must also talk about all the prescription drugs, nonprescription drugs, supplements, and herbal products you are taking because of possible drug interactions.

Always be watchful for an allergic reaction while taking this prescribed drug. Do not take this oral medication if you have a known allergy to aprepitant, fosaprepitant, or any inactive ingredients each capsule may contain. Signs of a hypersensitivity response are severe dizziness, hives, swelling of the face, trouble breathing, and skin rashes. If this occurs, immediately discontinue medication and seek emergency help.

Among the adverse effects of this drug are headache and dizziness. To avoid aggravating your condition, limit or stop drinking alcohol. You should also practice extreme caution when doing activities that require alertness, such as driving and using machinery.

There are still no definitive clinical trials on whether this drug could pose a potential danger to unborn babies and nursing infants. With this, pregnant and breastfeeding moms should take Emend only if needed.

Form and Strengths

Emend is available in the following form and strengths:

Emend Capsule:

• 80mg
• 125mg

FAQ

What is the difference between Emend and Zofran?

On Emend vs Zofran, The former prevents and stops nausea and vomiting while the latter could only prevent such symptoms.

Does this medication make you feel tired?

Yes, tiredness or fatigues are among the side effects of this drug.

When is the best time to take this medication?

It is best to take this drug in the morning because it causes insomnia.

Resources:

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/022023s017lbl.pdf
2. https://www.ncbi.nlm.nih.gov/books/NBK551588/
3. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=44f634f4-b794-4d55-8ab7-037fdef8ff0f