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Flagyl is an antibiotic medication used to treat trichomoniasis as well as protozoal and anaerobic infections. These include bacterial infections affecting the vagina, stomach liver, skin, joints, brain, spinal cord, lungs, heart, and bloodstream.

Metronidazole is a narrow spectrum antibiotic with an activity against protozoan bacteria. The antibiotic has deep tissue penetration and is fast at killing harmful bacteria such as anaerobes. This helps Flagyl treat various bacterial infections, especially trichomoniasis.

Trichomoniasis is a sexually transmitted disease caused by parasites; sexually active partners are usually treated together even if only one shows symptoms.

Uses and Dosage

The dose of Flagyl prescribed will depend on the person and infection being treated. Follow your doctor’s instructions on how to take this medication and for how long.

  • Swallow tablets whole
  • Take pills with or without food
  • Smooth cream onto affected area per doctor’s instructions
  • Flagyl is usually prescribed for up to 10 days
  • Use this medication for the full time prescribed
  • Do not take two doses of the tablets
  • Store at room temperature away from heat and moisture

Side Effects

This medication may cause some side effects while it kills harmful bacteria. Speak with your doctor for more information regarding symptoms you may encounter while taking Flagyl.

Common Flagyl side effects include:

  • Depression
  • Trouble sleeping
  • Feeling irritable
  • Headache, dizziness
  • Weakness
  • Nausea, vomiting
  • Loss of appetite, stomach pain
  • Diarrhea, constipation
  • Metallic taste
  • Rash, itching
  • Vaginal itching or discharge
  • Pain during sex
  • Mouth sores
  • Swollen or red tongue

Serious Side Effects

Some more serious side effects may occur when taking Flagyl. Call your doctor right away if you notice any of the following symptoms:

  • New or worsening infection
  • Painful or difficult urination
  • Confusion
  • Light-headed feeling like you might pass out
  • Vaginal itching or discharge
  • Blisters or ulcers in mouth
  • Red or swollen gums
  • Trouble swallowing

Stop taking Flagyl and seek medical attention if you have any neurologic side effects including:

  • Numbness, tingling, or burning in hands or feet
  • Vision problems, pain behind eyes, seeing flashes of lights
  • Muscle weakness, speech or coordination troubles
  • Confusion, trouble processing
  • Fever, neck stiffness
  • Sensitivity to light

Allergic Reactions

Do not use Flagyl if you are allergic to metronidazole, secnidazole, or tinidazole. Seek immediate medical attention if you notice any signs of an allergic reaction.

Flagyl allergy symptoms may include:

  • Hives
  • Itching
  • Warmth or tingling
  • Fever
  • Joint pain
  • Dry mouth
  • Vaginal dryness
  • Stuffy nose
  • Difficulty breathing
  • Swelling in face or throat
  • Sore throat
  • Burning eyes
  • Skin pain
  • Red or purple rash
  • Blistering or peeling skin


Avoid Flagyl if you have had alcohol in the past 3 days, consumed anything containing propylene glycol in the past 3 days, or if you have taken disulfiram within the past two weeks.

Do not take Flagyl to treat trichomoniasis in the first trimester of pregnancy. You also should not breastfeed up to 24 hours after using this medication.

To ensure safety, tell your doctor if you have ever had the following:

  • Liver or kidney disease
  • Heart rhythm disorder
  • Stomach or intestinal disease
  • Blood cell disorder or low white blood cell count
  • A fungal infection
  • A nerve disorder

Metronidazole may cause liver issues in people with Cockayne syndrome. Monitor your condition and tell your doctor immediately if you have any signs of liver failure: nausea, stomach pain, dark urine, clay-colored stools, or jaundice.

Some drugs may interact with metronidazole and cause unwanted side effects. Tell your doctor about any medications you take, especially the following:

  • An antidepressant
  • Asthma medication
  • Cancer medication such as busulfan
  • Heart or blood pressure medication
  • Antipsychotic medicine like lithium
  • Medication to treat malaria, HIV, or other infections
  • A blood thinner such as warfarin

Form and Strength

This medication is available in cream and tablet forms.

Flagyl cream strengths:

  • 10% in quantities of 60g
  • 10% in quantities of 120g

Flagyl tablet strengths:

  • 200mg
  • 250mg
  • 400mg
  • 500mg

Quantities of 90 are available for the 200 and 400mg strength tablets while groups of 100 are available for the 250 and 500mg tablets.


How long does it take for Flagyl to work?

Metronidazole is quickly absorbed into your system and starts working within two hours after first being taken. Within three hours, the medication reaches its maximum concentration, however it could take a couple of days before symptoms noticeably improve depending on your infection.

Can you drink alcohol with metronidazole?

It is recommended that you avoid drinking alcohol while taking Flagyl. Metronidazole could interact with the alcohol to cause a reaction. However, some studies have shown minimal interactions or reactions. If you are going to drink alcohol, limit the amount and monitor symptoms.

Can you have sex while taking Flagyl?

When taking either oral or cream Flagyl for an infection linked with sexual activity, it is recommended that you abstain from sex until you have completed your treatment. By doing this, you can help prevent reinfection.



Additional information

Brand Name:


Scientific Name:


Other Names:

Flagyl, Metrogyl, Metronidazole


200mg, 250mg, 400mg, 500mg

Quantities Available:

90, 100, 500


Capsule, Tablet