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Kemadrin is a medication that contains the active ingredient procyclidine, which belongs to a group of medicines called anticholinergics.

Kemadrin is primarily used for the treatment and symptomatic relief of Parkinson’s disease, including idiopathic Parkinson’s disease, postencephalitic Parkinson’s disease, and other forms of Parkinsonism.

The main purpose of Kemadrin is to help control the symptoms of Parkinson’s disease, such as tremors, muscle stiffness, and difficulty with movement. It works by blocking the effects of a neurotransmitter called acetylcholine, which is involved in controlling muscle movements.

Use and Dosage

Take this medication by mouth as directed by your doctor, usually 3 to 4 times a day after meals and at bedtime. Your doctor may start you at a low dose and increase your dose slowly to find the best dose for you. The dosage is based on your medical condition and response to therapy.

If you are using the liquid form of this medication, measure your dose with a special measuring spoon or device. Do not use a household spoon because it may not provide the correct dose.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Take this medication at least 1 hour before antacids containing magnesium, aluminum, or calcium. Allow at least 1-2 hours between doses of procyclidine and certain drugs for diarrhea (adsorbent antidiarrheals such as kaolin, pectin, and attapulgite). Take this medication at least 2 hours after ketoconazole. Antacids and some drugs for diarrhea may prevent the full absorption of procyclidine, and this product may prevent the complete absorption of ketoconazole when these products are taken together.

If you are taking this medication for side effects from another medication, your doctor may instruct you to take it on a regular schedule or only as needed. If you are taking this medication for Parkinson’s disease, your doctor may change the dose of your other medications (such as levodopa). Follow your doctor’s instructions closely. Do not stop or change the dose of your medication without your doctor’s approval.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Do not increase your dose, take it more often, or use it for a longer time than prescribed. Properly stop the medication when so directed. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.

When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well. Tell your doctor if your condition lasts or gets worse.

Side Effects

Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like: rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat
  • Very bad dizziness or passing out
  • Feeling confused
  • Feeling agitated
  • Hallucinations (seeing or hearing things that are not there)
  • Mental, mood, or behavior changes that are new or worse
  • Change in eyesight
  • A fast heartbeat
  • Trouble passing urine


  • Before taking procyclidine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
  • Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, breathing problems (such as asthma, emphysema), diarrhea caused by an infection, heart problems (such as angina, heart attack, heart failure, fast/irregular heartbeat), high/low blood pressure, stomach/intestinal problems (such as chronic constipation, ileus, blockage, ulcerative colitis, acid reflux, ulcer), kidney disease, liver disease, mental/mood problems (such as anxiety, dementia, psychosis), certain muscle disease (myasthenia gravis), certain nerve disease (autonomic neuropathy), seizure, stroke, overactive thyroid (hyperthyroidism), problems urinating (such as due to enlarged prostate, neurogenic bladder), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol).
  • This drug may make you dizzy, drowsy, or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
  • This medication decreases saliva production, an effect that can increase gum and tooth problems (such as cavities, and gum disease). Take special care with your dental hygiene (such as brushing, and flossing) and have regular dental check-ups.
  • This drug can cause decreased sweating, which could cause a severe rise in your body temperature (hyperthermia). The risk of this serious side effect is greater in hot weather, during vigorous exercise, and/or if you drink alcohol. Drink plenty of fluids and dress lightly while in hot weather and when exercising. If you experience signs of hyperthermia such as mental/mood changes, headache, or dizziness, promptly seek cool or air-conditioned shelter and/or stop exercising and get medical help right away. Consult your doctor for more details.
  • Liquid forms of this product may contain alcohol. Caution is advised if you have diabetes, alcohol dependence, or liver disease. Some medications (such as disulfiram, and metronidazole) may cause a serious reaction when combined with alcohol. Tell your doctor if you are taking any medication that should not be used with alcohol. Ask your doctor or pharmacist about using this product safely.
  • Older adults may be more sensitive to the side effects of this drug, especially dizziness, heat stroke, memory problems, and constipation.
  • Children may be more sensitive to the side effects of this drug, especially the effects on heart rate.
  • During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.
  • It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Form and Strengths

Kemadrin is available in the following forms and strengths:

  • Kemadrin Tablet:
    • 2.5 mg
    • 5 mg
  • Procyclidine Tablet:
    • 5 mg


What do I do if I miss a dose?

Take a missed dose as soon as you think about it.

If it is close to the time for your next dose, skip the missed dose and go back to your normal time.

Do not take 2 doses at the same time or extra doses.

What are some things I need to know or do while I take Procyclidine Tablets?

Tell all your healthcare providers you take this medicine (procyclidine tablets). This includes your doctors, nurses, pharmacists, and dentists.

If an overdose is suspected?

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.



Additional information

Brand Name:


Scientific Name:


Other Names:

Kemadrin, Procyclidine


2.5mg, 5mg

Quantities Available:

84, 100