Neo-Synalar Cream

Formulation : Cream
Dosage : 0.5/0.025%
Quantity : 60g
Prescription Required
(All Prices in USD)


Neo-Synalar cream is a prescription medication that contains two active ingredients: fluocinolone acetonide, a corticosteroid, and neomycin sulphate, an antibiotic.

Neo-Synalar cream is used topically to treat certain skin infections and conditions that respond to steroid medication, such as inflammation, itching, and infection.

Use and Dosage

This medication is for use on the skin only. Wash your hands before using. Clean and dry the affected area. Apply a thin film of medication to the affected area and gently rub in as directed by your doctor, usually 2 to 4 times a day. Wash your hands after use unless you are using this product to treat the hands.

Do not cover, bandage, or wrap the area unless directed to do so by your doctor.

Do not use large amounts of this medication or apply this more often or for a longer period than directed. Your condition will not improve any faster, and your risk of side effects will increase. This product is not recommended for use over a wide area of the body. Do not use this product for longer than 1 week unless directed by your doctor.

Avoid getting this medication in your eyes or inside the mouth or nose. If this occurs, wipe off the medication and rinse thoroughly with water.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.

Tell your doctor if your condition does not improve after 1 week.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Serious side effects include:

  • Hearing problems, ringing in your ears
  • Little or no urination
  • Worsening of your skin condition
  • Redness, warmth, swelling, oozing, or severe irritation of any treated skin; high blood sugar–increased thirst, increased urination, dry mouth, fruity breath odor
  • Signs of absorbing fluocinolone and neomycin topical through your skin–weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects of fluocinolone and neomycin topical may include:

  • Burning, itching, or irritation of treated skin
  • Increased hair growth
  • White or “pruned” appearance of the skin
  • Rash, pimples
  • Changes in the color of treated skin

This is not a complete list of side effects and others may occur.


  • Before using this product, tell your doctor or pharmacist if you are allergic to neomycin or fluocinolone; or to aminoglycoside antibiotics (such as gentamicin, and tobramycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
  • Before using this medication, tell your doctor or pharmacist your medical history.
  • This medication should not be used to treat an infection in the outer ear canal if the eardrum is torn (perforated).
  • Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.
  • Though it is unlikely, this medication may temporarily slow down a child’s growth if used for a long time. See the doctor regularly so your child’s height can be checked.
  • During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.
  • It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Forms and Strengths

Neo-Synalar Cream is available in the following forms and strengths:

  • Neo-Synalar Cream:
    • 0.5/0.025%


What happens if I miss a dose?

Apply the medicine as soon as you can but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose?

Seek emergency medical attention if anyone has accidentally swallowed the medication.

High doses or long-term use of fluocinolone and neomycin topical can lead to thinning skin, easy bruising, changes in body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using fluocinolone and neomycin topical?

Avoid applying fluocinolone and neomycin topical to your face, underarm, or groin area.

Do not use fluocinolone and neomycin topical to treat any skin condition that has not been checked by your doctor.

What other drugs will affect fluocinolone and neomycin topical?

Medicine used on the skin is not likely to be affected by other drugs you use. However, many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.



Additional information

Brand Name:

Neo-Synalar Cream

Scientific Name:

Neomycin Sulfate/Fluocinolone Acetonide

Other Names:

Neo-Synalar Cream



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