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Nitrostat is a medication that contains the active ingredient nitroglycerin.

Nitrostat is available as sublingual tablets and used to treat chest pain called angina.

Angina is characterized by recurring pain or discomfort in the chest when a part of the heart does not receive enough blood flow.

Use and Dosage

Ask your doctor now for exact instructions on how to use your nitroglycerin and when to call for emergency medical help.

Read the Patient Information Leaflet if available from your pharmacist before you start using nitroglycerin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Sit down before using this medication. Place 1 tablet under the tongue and allow it to dissolve as directed by your doctor. Do not chew or swallow the tablet. The dosage is based on your medical condition and response to treatment.

If you are using this medication to prevent chest pain before physical activities, use it 5 to 10 minutes before the activity.

If you are using this medication to relieve chest pain once it occurs, use it as soon as possible. If your chest pain has not improved or if it has worsened 5 minutes after you use this drug, call emergency medical help (911). After calling the emergency number, use another dose. Five minutes after the second dose, if you still have chest pain and the ambulance has not arrived, use a third dose. If your chest pain is not gone after 15 minutes and 3 doses of nitroglycerin, call emergency medical help if you have not called already. Do not use more than 3 doses during an attack unless directed by your doctor.

Side Effects

Get emergency medical help if you have signs of an allergic reaction to Nitrostat: hives, sweating, pale skin; nausea, vomiting; feeling weak or light-headed; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • Severe or throbbing headaches that do not become less severe with continued use of Nitrostat
  • Pounding heartbeats or fluttering in your chest
  • Slow heart rate
  • Light-headed feeling, like you might pass out
  • Blurred vision dry mouth
  • Heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating

Nitroglycerin can cause severe headaches that should become less severe as you continue to use the medicine.

Common Nitrostat side effects may include:

  • Flushing (sudden warmth, redness, or tingly feeling)
  • Feeling light-headed, fainting
  • Headache, dizziness
  • Numbness, tingling, burning pain

This is not a complete list of side effects and others may occur. 


  • Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide mononitrate); or nitrites; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
  • Before using this medication, tell your doctor or pharmacist your medical history, especially of: recent head injury, anemia, low blood pressure, dehydration, and other heart problems (such as a recent heart attack).
  • This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
  • Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
  • Older adults may be more sensitive to the side effects of this medication, especially dizziness and lightheadedness which could increase the risk of falls.
  • During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.
  • It is unknown if this medication passes into breast milk or if it may harm a nursing infant. Consult your doctor before breast-feeding.

Forms and Strengths

Nitrostat Sublingual is available in the following forms and strengths:

  • Nitrostat Sublingual Tablet:
    • 0.3 mg
    • 0.6 mg
  • Nitrostat Sublingual Tablet:
    • 0.4 mg
    • 0.6 mg


What happens if I miss a dose?

If you use Nitrostat on a regular schedule, skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention. An overdose of nitroglycerin can be fatal.

Overdose symptoms may include a throbbing headache, confusion, pounding heartbeats, vision problems, vomiting, bloody diarrhea, sweating, clammy skin, blue lips, weak or shallow breathing, loss of movement, seizure, or fainting.

What should I avoid while using Nitrostat?

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Drinking alcohol can increase certain side effects such as dizziness, drowsiness, feeling light-headed, or fainting.



Additional information

Quantities Available:

25, 100


Sublingual Tablet