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Formulation : ER Capsule
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Quantity: 100
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Norpace CR is a medication that contains the active ingredient disopyramide phosphate.

Norpace CR is used for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia.

Norpace CR is an extended-release formulation of disopyramide phosphate, designed to provide a gradual and consistent release of the medication over time.

Use and Dosage

Take this medication by mouth with or without food exactly as prescribed by your doctor. If you are taking the immediate-release form, take it as directed by your doctor, usually 4 times daily.

If you are taking the extended-release form, take it as directed by your doctor, usually twice a day. Swallow extended-release capsules whole. Do not crush or chew extended-release capsules or tablets. Doing so can release the entire drug at once, increasing the risk of side effects. Swallow the whole tablet without crushing or chewing.

The dosage is based on your age, medical condition, and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Serious side effects include:

  • New or a worsening irregular heartbeat pattern
  • Little or no urinating, painful or difficult urination
  • Light-headed feeling, like you might pass out
  • Shortness of breath (even with mild exertion), swelling, rapid weight gain
  • Low blood sugar (headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery)

Serious side effects such as heart failure or kidney problems may be more likely in older adults.

Common side effects of disopyramide may include:

  • Dry mouth, nose, or throat
  • Nausea, stomach pain, bloating
  • Constipation
  • Dry eyes, blurred vision
  • Headache, tiredness, general ill feeling
  • Muscle pain or weakness

This is not a complete list of side effects and others may occur.


  • Before taking disopyramide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
  • Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, glaucoma, kidney disease, liver problems, myasthenia gravis, and urinary problems (such as due to enlarged prostate, urinary retention).
  • This drug may rarely make you dizzy. Alcohol or marijuana (cannabis) can make you dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
  • Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
  • Disopyramide may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, and fainting) that need medical attention right away.
  • The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using disopyramide, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
  • Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using disopyramide safely.
  • This drug may cause low blood sugar (hypoglycemia), especially if you have diabetes, heart failure, decreased kidney/liver function, or nutrition problems. Tell your doctor right away if you have symptoms of low blood sugar including sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. If you have diabetes, your diabetes medication, exercise program, or diet may need to be adjusted.
  • Older adults may be more sensitive to the side effects of this drug, especially urination problems and QT prolongation (see above).
  • During pregnancy, this medication should be used only when needed. Rarely, disopyramide may cause early labour during pregnancy. Discuss the risks and benefits with your doctor.
  • This medication passes into breast milk, and the effect on a nursing infant is unknown. Consult your doctor before breast-feeding.

Forms and Strengths

Norpace CR is available in the following forms and strengths:

  • Norpace CR ER Capsule:
    • 100 mg


What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up for the missed dose.

What happens if I overdose?

Seek emergency medical attention. An overdose of disopyramide can be fatal.

Overdose symptoms may include trouble breathing, irregular heartbeats, and loss of consciousness.

What should I avoid while taking disopyramide?

Disopyramide may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Drinking alcohol can increase certain side effects of disopyramide.

What other drugs will affect disopyramide?

Many drugs can interact with disopyramide. Not all interactions are listed here. Tell your doctor about all your medications and any you start or stop using, especially:

  • Ketoconazole
  • Antibiotic–clarithromycin, erythromycin
  • Other heart rhythm medicines–encainide, flecainide, propranolol, propafenone, quinidine

This list is not complete, and many other drugs can interact with disopyramide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.



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ER Capsule