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Formulation : Orally Disintegrating Tablet
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Prolopa dispersible is indicated for the treatment of Parkinson’s disease in adults over 25 years of age.

Parkinson’s disease is a neurodegenerative disorder characterized by a deficiency of dopamine in the brain, leading to movement problems.

Prolopa dispersible contains levodopa and benserazide, which work together to increase dopamine levels in the brain and alleviate the symptoms of Parkinson’s disease.

Use and Dosage

Treatment with levodopa-benserazide should be started at low doses and increased gradually to reduce the risk of side effects while gaining maximum benefit from the medication.

For someone who has never taken levodopa, the recommended starting dose is one capsule of levodopa 100 mg – benserazide 25 mg once or twice a day. Your doctor will usually increase the dose by one capsule every third or fourth day until the best effect occurs without side effects.

When the dose gets higher, your doctor may increase the dose at 2 to 4-week intervals. This dose should be divided so that the medication is taken at least 4 times a day with, or immediately after, meals.

If you have been taking another form of levodopa, your doctor will determine your starting dose, based on the amount of levodopa you have been taking most recently. The dose of levodopa in levodopa-benserazide is usually quite a bit lower than your original dose. The benserazide helps the levodopa to get to where it is needed, so less levodopa is needed.

Most people find the best dose is 4 to 8 capsules of levodopa 100 mg – benserazide 25 mg daily (divided into 4 to 6 doses).

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the one above, do not change the way that you are taking the medication without consulting your doctor.

When first starting the medication, it may be taken with meals or a snack to reduce stomach upset. Protein prevents levodopa-benserazide from being absorbed. Take this medication with a small snack, such as crackers or biscuits to help prevent an upset stomach.

Swallow the capsules whole and do not open them. Do not dissolve them in liquid.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Side Effects

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • Dark sweat or urine
  • Diarrhea
  • Dizziness, faintness, or lightheadedness when rising from a lying or sitting position
  • Increase in sexual ability or desire
  • Increased sweating
  • Nausea
  • Nightmares
  • Stained saliva or mouth, teeth, and gums
  • Vomiting

Although most of the side effects listed below do not happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • Compulsive behavior (e.g., gambling, spending)
  • False or unusual sense of well-being
  • Fast, slow, or irregular heartbeat
  • Fainting
  • Impaired ability to think
  • Mood or mental changes
  • Agitation
  • Anxiety
  • Confusion
  • Delusions
  • Fearfulness
  • Hallucinations (seeing or hearing things that are not there)
  • Nervousness
  • Restlessness
  • Suspiciousness
  • Signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities,
  • thoughts of suicide)
  • Taking more medication than ordered
  • Unwanted movements or difficulty moving
  • Absence of or decrease in body movement
  • Clenching, gnashing, or grinding teeth
  • Inability to move the eyes
  • Increased blinking or spasms
  • Increased blinking or twitching of eyelids
  • Increased hand tremor
  • Muscle twitching
  • Shakiness and unsteady walking, clumsiness, trembling problems with muscle control or coordination
  • Sudden freezing, hypotonia (decreased muscle tone), and postural instability
  • Tightness of the mouth, lips, or tongue
  • Twitching, twisting, uncontrolled repetitive movements of tongue, lips, face, arms, or legs
  • Twisting of the neck to one side (torticollis)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • Signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • Sudden onset of sleep

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptoms that worry you while you are taking this medication.


  • Avoid abrupt withdrawal of therapy with levodopa and benserazide, as dopaminergic agents have been associated with a syndrome resembling neuroleptic malignant syndrome (NMS) when therapy is abruptly stopped or significantly reduced after long-term use. Withdraw therapy gradually and monitor closely.
  • Prolopa Dispersible can interact with some medications used during surgery. If you have surgery planned, inform your surgeon and anesthetist that you are taking Prolopa Dispersible.
  • Benserazide is normally given in combination with levodopa as the combination product Prolopa. Levodopa should not be taken with protein-rich foods as they may reduce its absorption. Take Prolopa Dispersible with or without food.
  • The dosage of Prolopa Dispersible should be determined by your doctor based on your individual needs and response to the medication. The starting dose and subsequent adjustments will depend on factors such as whether you have previously taken levodopa and the severity of your condition. Follow your doctor’s instructions regarding the dosage and frequency of administration.

Forms and Strengths

Prolopa Dispersible is available in the following forms and strengths:

  • Prolopa Dispersible Orally Disintegrating:
    • 100/25mg


What are dispersible tablets?

Dispersible tablets are a type of tablet that can be dissolved in water or another liquid before being consumed. They are designed to be easily dissolved, making them convenient for people who have difficulty swallowing traditional tablets.

How do I take dispersible tablets?

Dispersible tablets should be placed in a glass of water or liquid and stirred until fully dissolved. The resulting solution can then be consumed. Follow the specific instructions provided by your healthcare professional or the medication’s packaging.

Can dispersible tablets be taken without water?

In most cases, dispersible tablets are designed to be dissolved in water or another liquid. However, some dispersible tablets may be suitable for direct administration without water. Check the instructions provided with the specific medication.

Are there any special storage requirements for dispersible tablets?

Dispersible tablets should be stored according to the instructions provided by the manufacturer. In general, they should be kept in a cool, dry place away from direct sunlight and moisture. Check the specific storage requirements for the medication you are taking.

Can dispersible tablets be split or crushed?

Dispersible tablets are typically designed to be dissolved in water or liquid and should not be split or crushed unless specifically instructed by your healthcare professional or the medication’s packaging.



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Orally Disintegrating Tablet