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Remeron is an antidepressant used to treat major depressive disorder (MDD) as well as anxiety and sleep disturbances.

Mirtazapine is a noradrenergic and specific serotonergic antidepressant that supports and enhances norepinephrine and serotonergic neurotransmission. Remeron is not focused on blocking presynaptic absorption of norepinephrine and serotonin, like selective serotonin reuptake inhibitors (SSRIs), but blocks specific receptors to increase noradrenergic and serotonergic activity.

Thanks to Remeron’s enhancement of norepinephrine and serotonin, the medication is effective at relieving symptoms of depression. By blocking certain receptors, mirtazapine also offers anxiolytic and sedative properties to improve symptoms of anxiety and insomnia that may occur alongside depression.

Uses and Dosage

The dose prescribed of Remeron will vary depending on the individual and condition being treated. Follow all your doctor’s instructions and read packaging labels carefully.

  • Take with or without food
  • Take in the evening at the same time each day
  • Swallow tablet whole with water
  • Adults usually start with 15mg once daily before bed
  • Do not take more than 45mg daily
  • Do not take two doses at once
  • Symptoms may take up to 4 weeks to improve
  • Do not suddenly stop taking Remeron
  • Store away from moisture and light at room temperature

Side Effects

Remeron may cause some side effects while it enhances your levels of norepinephrine and serotonin. Speak with your doctor for more information regarding any symptoms you may encounter when taking mirtazapine.

Thanks to mirtazapine’s composition and mechanism of action, adverse side effects tend to be less common than tricyclic antidepressants and SSRIs.

Common Remeron side effects:

  • Drowsiness, dizziness
  • Increased appetite
  • Weight gain

Serious Side Effects

Some more serious side effects may occur when taking mirtazapine. Stop using Remeron and call your doctor right away if you notice any of the following symptoms:

  • Racing thoughts, decreased need for sleep, risk-taking behaviour
  • Feeling extremely happy or sad
  • Blurred or tunnel vision, seeing halos around lights
  • Eye pain or swelling
  • Light-headed feeling like you might pass out
  • Severe rash, blisters, or swelling on palms or soles of your feet
  • Seizure
  • Low white blood cell count (fever, chills, sore throat, cough, mouth or nose sores, flu-like symptoms, difficulty breathing)
  • Low sodium levels (headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, unsteadiness)

Seek immediate medical attention if you develop symptoms of serotonin syndrome, which include agitation, hallucinations, fever, sweating, shivering, quickened heart rate, stiff muscles, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Allergic Reactions

Do not take Remeron if you are allergic to mirtazapine or any of the ingredients used for the tablet. If you notice signs of an allergic reaction, stop taking this antidepressant and call your doctor.

Remeron allergy symptoms may include:

  • Hives
  • Joint pain
  • Fever
  • Difficulty breathing
  • Swelling in face or throat
  • Fever
  • Sore throat
  • Burning eyes
  • Skin pain, red or purple rash
  • Blistering and peeling skin


Do not take Remeron if you also take tryptophan because the two medications can interact and cause adverse reactions.

Avoid drinking alcohol while taking Remeron because it can increase some mirtazapine side effects.

Do not take this antidepressant if you have used an MAO inhibitor within the last 14 days. These inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and others.

To ensure the safety of taking this medication, tell your doctor if you have ever had any of the following:

  • Low white blood cell counts
  • Glaucoma
  • Liver or kidney disease
  • Low blood sodium levels
  • Seizure
  • Depression, suicidal thoughts or actions
  • Bipolar disorder in you or a family member
  • Heart problems or stroke
  • High cholesterol or triglycerides
  • Long QT syndrome in you or a family member
  • Low blood pressure

Some medications can interact with mirtazapine. Let your doctor know if you also take any stimulant medications, opioid medicines, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraines, serious infections, or for preventing nausea and vomiting. These kinds of medications could lead to a serious condition called serotonin syndrome when taking with Remeron.

Tell your doctor about all the medications you take to ensure they won’t interact with mirtazapine, especially the following:

  • Cimetidine
  • Diazepam
  • St. John’s wort
  • Tramadol
  • Tryptophan
  • An antibiotic
  • Antifungal medication
  • HIV or AIDS antiviral medication
  • Migraine medicine
  • Medication for mood or thought disorders
  • Seizure medication

Some younger individuals may have suicidal thoughts when they first start taking an antidepressant. Monitor your progress while taking Remeron and tell your doctor about any changes in mood or symptoms.

Tell your doctor about any new or worsening symptoms you encounter, especially the following:

  • Changes in mood or behaviour
  • Anxiety
  • Panic attacks
  • Trouble sleeping
  • Feeling impulsive, irritable, agitated, hostile, or restless
  • Hyperactive
  • More depressed
  • Thoughts of suicide or self-harm

Remeron should not be given to anyone younger than 18 years old without medical advice. Mirtazapine is not approved an approved treatment for children.

Consult with your doctor if you are pregnant or breastfeeding.

This antidepressant may take up to 4 weeks before your symptoms will improve. Keep using Remeron as directed and consult with your doctor if symptoms do not improve after this time.

Remeron may affect your ability to think and react. Avoid driving or performing tasks that require alertness until you know how this medication affects you.

Do not suddenly stop taking Remeron or you may develop symptoms of withdrawal such as: dizziness, vomiting, agitation, sweating, confusion, numbness, tingling, or electric shock feelings.

Form and Strength

This medication is available in tablet form.

Remeron tablet strengths:

  • 15mg
  • 30mg
  • 45mg

The 15, 30, and 45mg tablets are all available in quantities of 100 while the 30mg ones are also available in groups of 28 and 84.


How long does it take for Remeron to work?

Remeron usually takes between 4 and 6 weeks to work into your systems and provide full effects. However, some may experience an improvement in symptoms after a week, such as a decrease in anxiety and sleeping problems.

Will Remeron affect my contraception?

Mirtazapine is not known to affect any type of contraception including the combined pill and emergency contraception such as Plan B. If Remeron causes you to vomit or have diarrhea for more than 24 hours, your body may not be able to absorb contraceptive pills as effectively.

Does Remeron cause weight gain or loss?

One of mirtazapine’s side effects is an increase in appetite which could lead you to eat more than usual. Your weight may fluctuate with side effects but shouldn’t become serious or extreme. Speak with your doctor if you have concerns to implement a treatment plan.



Additional information

Brand Name:


Scientific Name:


Other Names:

Mirtaz, Mirtazapine, Remeron


15mg, 30mg, 45mg

Quantities Available:

28, 50, 84, 100, 200


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