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Rilutek is a central nervous system drug used to treat amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease).

Riluzole is a benzothiazole drug whose mechanism of action is unclear. The drug binds to albumin and lipoproteins to help delay the progression of ALS and increase the quality of life for patients with the disease.

Uses and Dosage

The dose of Rilutek that is prescribed will vary depending on the individual being treated and the severity of their ALS. Follow all your doctor’s instructions and read packaging labels carefully to ensure the best results during treatment with riluzole.

  • Swallow tablets whole
  • Take on an empty stomach 1 hour before or 2 hours after eating
  • Most adults take 50mg twice daily
  • Store at room temperature away from children and pets

Side Effects

Rilutek may cause some side effects to develop while slowing the progression of your ALS. Speak with your doctor for more information regarding any symptoms that you may experience when taking riluzole.

Common Rilutek side effects:

  • Increased blood pressure
  • Numbness or tingling around your mouth
  • Weakness, dizziness
  • Stomach pain, nausea
  • Trouble breathing

Serious Side Effects

Some more serious adverse reactions may occur when taking riluzole. Stop using Rilutek and call your doctor if you notice any of the following side effects:

  • Sudden chest pain, wheezing, shortness of breath
  • Dry cough or cough with mucus
  • Low white blood cell count (fever, mouth sores, skin sores, sore throat)
  • Liver problems (nausea, loss of appetite, stomach pain, tiredness, itching, dark urine, jaundice)

Allergic Reactions

Do not take Rilutek if you are allergic to riluzole or any of the other listed tablet ingredients. If you develop signs of an allergic reaction, stop using this medication and contact your doctor right away.

Rilutek allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


Tell your doctor if you have ever had liver disease to ensure your safety when taking Rilutek.

Tell your doctor if you are pregnant and use effective birth control during treatment with Rilutek. Riluzole may cause harm to an unborn baby if taken during pregnancy.

Ask your doctor before breastfeeding while taking Rilutek to discuss the benefits and risks.

Some patients taking Rilutek have reported developing interstitial lung disease. Stop using this medication right away if you develop this condition or hypersensitivity pneumonitis.

Some drugs may interact with riluzole and cause adverse reactions. Tell your doctor about all the medications you take, including over the counter medicines, but especially any of the following:

  • CYP1A2 inhibitors (ciprofloxacin, enoxacin, fluvoxamine, and others)
  • CYp1A2 inducers
  • Drugs that may cause harm to your liver (allopurinol, methyldopa, sulfasalazine, and others)

Rilutek is not an approved form of treatment for anyone under the age of 18 years old.

Form and Strength

This ALS medication is available in tablet form.

Rilutek tablet strength:

  • 50mg

The 50mg Rilutek tablets are available in quantities of 56, 60, and 180.


Should Rilutek be taken before or after meals?

You should take your doses of Rilutek on an empty stomach, but the exact time you take your dose each day is up to you and your doctor. Ensure that you take your dose at least 1 hour before or 2 hours after eating. Taking riluzole on an empty stomach helps ensure that your body absorbs the drug so that it can provide its full effects.

Can Rilutek make you tired?

One of the side effects that is commonly reported by Rilutek users includes feeling weak, but the medication shouldn’t make you drowsy. Other common symptoms include an increase in blood pressure, numbness or tingling around your mouth, dizziness, stomach pain, and nausea. Speak with your doctor for more information if you have any concerns.



Additional information

Brand Name:


Scientific Name:


Other Names:

Rilutek, Riluzole



Quantities Available:

56, 60, 112, 180