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Sandomigran DS is used to prevent and treat migraine headaches.

Pizotifen is a serotonin and tryptamine antagonist that inhibits certain chemicals in your brain to prevent blood vessels from widening and altering your pain threshold. When taken daily, Sandomigran DS reduces the severity and frequency of migraine headache attacks.

Dosage and Administration

The dose of Sandomigran DS that is prescribed may vary depending on the individual and migraine severity being treated. Follow all directions given by your healthcare provider and read packaging labels carefully to ensure the best results from treatment. Do not take more than prescribed or suddenly stop taking the medication.

  • Take with or without food
  • Take your doses at the same times each day
  • Adults and children over 12 usually start by taking 0.5mg daily at night
  • Doses gradually increase to 1.5mg taken before bed or in three divided doses
  • Doses can range from 1 to 6mg daily
  • Do not take more than 3 mg in a single dose
  • Most patients take a maintenance dose of 1.5 mg
  • Adolescents over 12 normally take a maximum single dose of 1mg nightly
  • Adolescents may take up to a maximum of 1.5mg in divided doses
  • Store at room temperature away from children and pets

Side Effects

Sandomigran DS may cause some side effects while altering chemicals in your brain. Speak to your healthcare provider for more information about any symptoms that you might experience.

Common Sandomigran DS side effects:

  • Drowsiness, tiredness
  • Increased appetite, weight gain
  • Dizziness
  • Nausea, vomiting
  • Dry mouth
  • Constipation
  • Muscle or joint pain
  • Problems sleeping

Serious Side Effects

More serious adverse reactions may occur during treatment with Sandomigran DS. Contact your healthcare provider if you experience any of the following symptoms:

  • Liver problems (jaundice, abdominal pain, nausea, vomiting, decreased appetite)
  • Depression, anxiety, or other mood changes
  • Changes in behaviour like aggression or agitation
  • Visual or auditory hallucinations
  • Tingling or prickling sensations
  • Problems with your vision
  • Seizures

Allergic Reactions

Do not take Sandomigran DS if you are allergic to pizotifen or any of the other tablet ingredients. Contact your healthcare provider right away if you experience any of the following signs of an allergic reaction:

  • Swelling mouth, face, tongue, or throat
  • Itching, blistering skin
  • Rash


  • Do not use Sandomigran DS if you have taken a monoamine oxidase inhibitor (MAOI) within 14 days or if you have a stomach or intestinal blockage.
  • Before taking Sandomigran DS, tell your healthcare provider if you have ever had any of the following conditions:
    • Glaucoma
    • Difficulty urinating
    • Kidney or liver problems
    • Diabetes or heart problems
    • Epilepsy or seizures
  • Ask your healthcare provider before using Sandomigran DS while pregnant and let them know right away if you become pregnant during treatment.
  • Sandomigran DS can pass into breastmilk and may affect your nursing child. Consult your healthcare provider about the risks and benefits before starting treatment.
  • Do not suddenly stop taking Sandomigran DS because you could experience symptoms of withdrawal including depression, tremors, nausea, anxiety, sleep problems, and more.
  • Do not drive or use machinery until you know how Sandomigran DS will affect you because it can make you dizzy and drowsy.
  • Avoid drinking large amounts of alcohol during treatment because it can cause an increase in side effects, especially dizziness and drowsiness.
  • Some drugs may interact with Sandomigran DS and cause adverse reactions. Tell your healthcare provider about all the medications you take, including over the counter medicines, but especially any of the following:
    • Medicines used to treat anxiety
    • Medications used to treat depression and other mood disorders
    • Sleeping pills
    • Antihistamines
    • Cough and cold medications
    • Blood pressure medications
  • Sandomigran DS is not an approved treatment for any child under the age of 12.

Form and Strength

This migraine medication is available in tablet form.

  • Sandomigran DS tablet strength:
    • 1 mg

The 1 mg strength Sandomigran DS tablets are available in quantities of 100.


When is the best time to take Sandomigran DS?

When taking single daily doses of Sandomigran DS, it is recommended that you take them at night before bed. Those who are prescribed divided doses should take them at the same times each day, in the morning and evening.

Does Sandomigran make you sleepy?

A common side effect of Sandomigran DS is drowsiness. This is more likely to occur if you take other medications that make you drowsy or if you drink alcohol during treatment. Speak with your healthcare provider to learn more about any side effects you may have during treatment.



Additional information