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Formulation : Nasal Spray
Drug Name Dosage Quantity Price Buy Now
2mg/mL 60ds $198.10 Add To Cart
Dosage: 2mg/mL
Quantity: 60ds
Price: $198.10


Synarel Nasal Spray is a medication used for various purposes, including the hormonal management of endometriosis and as part of controlled ovarian stimulation programs before in-vitro fertilization (IVF) under the supervision of an infertility specialist.

Synarel Nasal Spray is a nasal spray solution containing nafarelin acetate as the active component.

Nafarelin acetate is a synthetic hormone that is similar to a natural hormone produced in the brain.

Use and Dosage

Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using Nafarelin each time you get a refill. Follow the illustrated directions for the proper use of this medication. If you have any questions, ask your doctor or pharmacist.

Follow the instructions for test sprays in the air if you are using a bottle for the first time. A fine mist is a sign that the spray is working properly.

Gently blow your nose before using this drug. For very young children, it may be necessary to clear the nose with a bulb syringe.

Use this medication as directed by your doctor, usually twice daily (about every 12 hours). If you are using more than 1 spray at a time, wait 30 seconds between each spray. Avoid spraying this medication in your eyes. Also, avoid sneezing during or right after using this medication because this may decrease the amount of medication absorbed. Follow the detailed instructions for cleaning the spray tip. It is important to clean the spray tip after each use.

The dosage and length of treatment are based on your medical condition and response to treatment.

It is very important to continue using this medication exactly as prescribed by your doctor. Do not skip any doses. To help you remember, use it at the same times each day.

Ask your doctor or pharmacist to find out how long each bottle of the nasal spray should last. Do not use the nasal spray bottle longer, even if there is medication left over, because you will not get a full dose. Make sure to get your medication refills a few days early so that you will not run out of your medication.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

If you need to use a nasal decongestant spray while using this medication, wait at least 2 hours after using this medication before using the decongestant.

When you first start this medication, worsening of symptoms may occur (such as increased vaginal bleeding for women treating endometriosis, vaginal bleeding/period, increase in breast size/pubic hair, oily skin, or body odour for children treating early puberty). These symptoms should get better after the first month of treatment. Tell your doctor if your symptoms do not get better or if they get worse after 2 months of treatment.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: itching, rash, or hives; chest pain, difficulty breathing; swelling of your face, lips, tongue, or throat.

Synarel may cause serious side effects include

  • Vaginal spotting or continued menstrual bleeding
  • Pelvic pain or swelling
  • Seizure
  • Depression–mood changes, feelings of low self-worth, loss of interest in things you once enjoyed, new sleep problems, thoughts about hurting yourself
  • Increased pressure inside the skull–severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes
  • Signs of a pituitary gland problem–sudden headache, confusion, vision changes, vomiting, weak pulse, slowed breathing

Some children using nafarelin have had new or worsening mental problems. Call your doctor right away if your child has any unusual changes in mood or behaviour (anger, aggression, crying, feeling restless or irritable).

Some side effects can be expected during the first month of using Synarel and are not a reason to stop using the medicine. Tell your doctor if you have any side effects that are ongoing or bothersome.

Common side effects of Synarel may include:

  • Vaginal bleeding, discharge, or dryness
  • Hot flashes
  • Acne
  • Increase or decrease in breast size
  • Runny nose
  • Headaches, muscle pain
  • Mood changes
  • Decreased interest in sex
  • Itchy, red, or flaky rash
  • Increased body odor
  • Increase in pubic hair growth

This is not a complete list of side effects and others may occur.


  • Before using nafarelin, tell your doctor or pharmacist if you are allergic to it; or to GnRH or other GnRH-like hormones (such as leuprolide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
  • Before using this medication, tell your doctor or pharmacist your medical history, especially of: unexplained abnormal vaginal bleeding, smoking, daily alcohol use, bone loss (osteoporosis) or family history of osteoporosis, polycystic ovarian disease, high cholesterol/triglyceride levels, seizures, mental/mood problems (such as depression).
  • Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
  • This medication must not be used during pregnancy. It may harm an unborn baby. Women should start this medication between days 2 and 4 of their period. Although periods and the release of eggs (ovulation) may stop while you are using this drug, this is not a reliable form of birth control. Discuss the use of non-hormonal forms of birth control (such as condoms, and diaphragm with spermicide) with your doctor. If you become pregnant or think you may be pregnant, tell your doctor right away.
  • It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breastfeeding is not recommended while using this medication. Consult your doctor before breastfeeding.

Forms and Strengths

Synarel Nasal Spray is available in the following forms and strengths:

  • Synarel Nasal Spray:
    • 2 mg/ml


What happens if I miss a dose?

Use the medicine as soon as you can but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

You must not miss a dose of Synarel.

What happens if I overdose?

Seek emergency medical attention.

What should I avoid while using Synarel?

Try not to sneeze or blow your nose just after using the spray. This can make Nafarelin less effective.

Avoid using any other nasal sprays within 2 hours after your dose of nafarelin nasal. If you have a stuffy nose, ask your doctor before using a decongestant nasal spray.



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Nasal Spray