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Treximet is an antimigraine medication used to treat migraine headaches that have already begun.

This medication combines sumatriptan, an antimigraine drug, with naproxen, a nonsteroidal anti-inflammatory drug (NSAID), to treat an active migraine. Sumatriptan inhibits the release of neuropeptides and constricts blood vessels in your brain to counteract migraine effects. Naproxen offers analgesic and anti-inflammatory effects by inhibiting prostaglandins that mediate inflammation and affect your nerves.

The combination of drugs used in this medication allows Treximet to relieve migraine headaches that have already begun thanks to their anti-inflammatory, pain-relieving, and anti-migraine actions.

Dosage and Administration

The dose of Treximet that is prescribed will vary depending on the individual and the severity of their migraines being treated. Follow all your healthcare provider’s instructions and read packaging labels carefully to ensure the best therapeutic response. Do not change your dose on your own or use this medication in other ways than prescribed.

  • Swallow tablet whole
  • Take with or without food
  • Take a dose of Treximet at the first signs of a migraine headache
  • If you do not feel any relief from your dose, talk with your healthcare provider
  • If your migraine returns or you only achieve minor relief, you can take a second dose 2 hours following your first
  • Do not take more than 2 doses of Treximet within 24 hours
  • Children aged 12 to 17 should not take more than 1 dose within 24 hours unless directed to do otherwise by their healthcare provider
  • Do not use Treximet to treat more than 5 migraine headaches in 30 days for adults or 2 headaches in 30 days for adolescents aged 12 to 17
  • Store at room temperature away from children and pets
  • Keep container securely closed when not using

Side Effects

Treximet may cause some side effects to develop while helping treat your migraine headaches. Speak with your healthcare provider to learn more about any symptoms you may have when taking this medication.

Common Treximet side effects:

  • Dizziness, drowsiness
  • Weakness or tiredness
  • Irregular heartbeats
  • Numbness or tingling in your fingers or toes
  • Dry mouth, heartburn, nausea
  • Feeling hot
  • Muscle tightness
  • Pain or pressure in your chest or throat

Serious Side Effects

Some more serious side effects may occur during treatment with Treximet. Stop using this medication and contact your healthcare provider right away if you notice any of the following symptoms:

  • Numbness, tingling, pale or blue-coloured fingers or toes
  • Leg cramps, burning, coldness, heaviness in your feet or legs
  • Severe headache, blurred vision, pounding in your neck or ears
  • Seizure
  • Heart problems (swelling, rapid increase in weight, shortness of breath)
  • High serotonin levels (agitation, hallucinations, fever, sweating, shivering, quick heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea)
  • Kidney problems (little or no urination, swelling in ankles or feet, tiredness, shortness of breath)
  • Liver problems (loss of appetite, stomach pain, tiredness, itching, dark urine, clay-coloured stool, jaundice)
  • Low red blood cell counts (pale skin, unusual tiredness, feeling lightheaded or short or breath)
  • Stomach bleeding (bloody or tarry stools, coughing blood, vomit that looks like coffee grounds)
  • Stomach problems (sudden severe stomach pain, vomiting, constipation, bloody diarrhea, weight loss)

Seek immediate medical attention if you have any signs of a heart attack or stroke. These signs may include chest pain that spreads to your jaw or shoulder, sudden numbness, weakness on one side of your body, slurred speech, and shortness of breath.

Stop taking Treximet and seek medical attention right away if you develop a serious drug reaction. Symptoms may include a rash, fever, swollen glands, muscle pain, severe weakness, unusual bruising, jaundice.

Allergic Reactions

Do not take Treximet if you are allergic to sumatriptan, naproxen, or any of the other tablet ingredients. If you develop an allergic reaction, stop using the medication and call your healthcare provider.

Treximet allergy symptoms may include:

  • Hives, red or purple rash
  • Skin pain
  • Blistering or peeling skin
  • Difficulty breathing
  • Swelling of face or throat
  • Fever
  • Sore throat
  • Burning eyes


Do not take Treximet if you have any of the following:

  • Heart problems or a history thereof
  • If you are about to have a heart bypass surgery or just underwent the procedure
  • Stroke, transient ischemic attack, or problems with circulation
  • Hemiplegic migraines or basilar migraines
  • Narrowing blood vessels in your legs and arms, stomach, or kidneys
  • Uncontrolled high blood pressure
  • Had an asthma attack, hives, or allergic reaction after taking another NSAID

Do not use Treximet if you have taken a triptan medicine, ergot medication, or serotonin receptor agonist within the last 24 hours.

If you have taken an antidepressant or monoamine oxidase inhibitor (MAOI) in the last 2 weeks.

To ensure your safety when taking Treximet, tell your healthcare provider if you have ever had any of the following:

  • High blood pressure
  • Asthma
  • High cholesterol levels
  • Diabetes
  • Personal or family history of heart problems or stroke
  • Liver or kidney problems
  • Epilepsy or another seizure disorder

Tell your healthcare provider if you are pregnant or plant to become pregnant during treatment with Treximet. Taking any NSAID, including Treximet, at 20 weeks of pregnancy or later could cause harm to your unborn baby.

Consult with your healthcare provider about how to breastfeed while taking Treximet because the medication can pass into your breastmilk and affect your nursing child.

Avoid driving or performing any hazardous tasks until you know how this medication will affect you. Do not perform these activities if Treximet causes you to become dizzy, weak, or drowsy.

Treximet may cause you to develop stomach or intestinal ulcers or bleeding during treatment. These can happen anytime during treatment without warning.

Ask your healthcare provider before using any medicines for pain, fever, swelling, or cold or flu symptoms because they can contain similar ingredients to naproxen.

Avoid drinking alcohol during treatment with Treximet because it can increase your risk of stomach bleeding.

Some drugs may interact with Treximet and cause adverse reactions. Tell your healthcare provider about all the medications you take, but especially any of the following:

  • Cyclosporine
  • Lithium
  • Methotrexate
  • Heart or blood pressure medications
  • Diuretic medicines
  • Blood thinners
  • Steroid medications like prednisone or dexamethasone
  • Certain antidepressant medications

Treximet is not an approved treatment for anyone under the age of 12.

Form and Strength

This antimigraine medication is available in tablet form.

Treximet tablet strength:

  • 85mg sumatriptan / 500mg naproxen

The 85/500mg strength Treximet tablets are available in quantities of 2, 6, and 8.


What not to do while taking Treximet?

You should avoid driving or performing dangerous tasks because Treximet may cause you to become dizzy, weak, or drowsy. Treximet may be harsh on your stomach, so you should also avoid drinking alcohol during treatment with this antimigraine medication. Follow all your healthcare provider’s instructions for the best results during treatment.

Why can you only take Treximet twice a week?

It is recommended that you not take Treximet more than 5 times in 30 days and no more than two doses within 24 hours because taking more could make your headaches worse. This antimigraine medication should offer relief from your headache and its symptoms after one or two doses. If this medication does not offer satisfactory relief or if you experience multiple migraines a week, contact your healthcare provider.



Additional information

Brand Name:


Scientific Name:

Sumatriptan Succinate/Naproxen Sodium

Other Names:

Headset, Suvexx



Quantities Available:

2, 6, 8, 9, 18