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Formulation : Tablet
Drug Name Dosage Quantity Price Buy Now
Perphenazine 2mg 100 $37.88 Add To Cart
Perphenazine 4mg 100 $40.15 Add To Cart
Perphenazine 8mg 100 $29.50 Add To Cart
Perphenazine 16mg 100 $42.93 Add To Cart
Dosage: 2mg
Quantity: 100
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Dosage: 4mg
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Dosage: 8mg
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Dosage: 16mg
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Trilafon is an antipsychotic medication used to treat schizophrenia and other psychotic disorders. This medication is also used to control severe nausea and vomiting.

Perphenazine is a phenothiazine antipsychotic that offers antiemetic and weak sedative properties. The drug balances chemicals in your brain such as dopamine to help you think more clearly and reduce nervousness, aggression, and hallucination. All these actions allow Trilafon to treat symptoms of psychotic disorders such as schizophrenia or bipolar disorder.

Dosage and Administration

The dose of Trilafon that is prescribed will vary depending on the individual and type of mental disorder being treated. Follow all your healthcare provider’s directions and read packaging labels carefully for the best therapeutic results. Do not change your dose on your own or suddenly stop taking this medication.

  • Swallow tablets whole
  • Take with or without food
  • Use lowest effective dose to manage symptoms
  • Store at room temperature away from children and pets

To treat psychotic disorders:

  • Most adults start by taking 4 to 8mg three times a day
  • Adults should not take more than 24mg a day
  • After initial management of symptoms, reduce dose to the lowest effective amount
  • Trilafon may take up to 4 or 6 weeks to provide its full benefit; continue taking this medication as prescribed
  • Contact your healthcare provider if your symptoms worsen or do not improve after 6 weeks

To control nausea and vomiting:

  • Most adults take 8 to 16mg divided daily
  • Doses of 24mg may be needed but reduce as soon as possible
  • Children should take 8mg daily in divided doses

Side Effects

Trilafon may cause some side effects to develop while affecting the chemicals in your brain. Speak with your healthcare provider to learn more about any reactions you may have when taking this antipsychotic.

Common Trilafon side effects:

  • Mild dizziness or drowsiness
  • Headache, blurred vision
  • Insomnia, strange dreams
  • Decreased appetite, vomiting, diarrhea, constipation
  • Increased sweating or urination
  • Dry mouth, stuffy nose
  • Swollen breasts
  • Unusual discharge
  • Mild rash or itching

Serious Side Effects

Some more serious adverse effects may occur when using Trilafon. Contact your healthcare provider right away if you develop any of the following symptoms:

  • Uncontrollable muscle movements in your arms, legs, or face
  • Worsening schizophrenia symptoms
  • Confusion, paranoia
  • Feeling restless or excited
  • Seizures
  • Lightheadedness, feeling faint
  • Jaundice
  • Little or no urination
  • Slow heartbeat, weak pulse, shallow breathing
  • Low white blood cell count (fever, chills, mouth sores, skin sores, sore throat, cough, difficulty breathing, lightheadedness)
  • Severe nervous system reaction (stiff or rigid muscles, high fever, sweating, fast or uneven heartbeats)

Allergic Reactions

Do not use Trilafon if you are allergic to perphenazine, any other phenothiazine, or any of the other listed tablet ingredients. Call your healthcare provider immediately if you experience any of the following signs of an allergic reaction:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


Do not use Trilafon if you have any of the following conditions:

  • Liver disease
  • Brain damage
  • Bone marrow depression
  • Blood cell disorder

Do not take Trilafon if you drink large amounts of alcohol on a regular basis.

If you take any medications that make you sleep, do not use Trilafon.

Older patients with dementia-related psychosis should not use Trilafon to treat their symptoms because the medication may increase their risk of death.

Using Trilafon at high doses or for long-term could lead to the development of a serious movement disorder that may not be reversible. Your risk of developing this condition increased the longer you use this medication, especially if you are a woman or an older adult.

To ensure your safety when taking this medication, tell your healthcare provider if you have ever had any of the following:

  • Severe or untreated depression
  • Heart disease or high blood pressure
  • Kidney disease
  • Severe breathing problems like asthma or emphysema
  • Seizures
  • Parkinson’s disease
  • Breast cancer
  • Adrenal gland tumour
  • An enlarged prostate or troubles urinating
  • Glaucoma
  • Serious reaction after using a phenothiazine medication

Tell your healthcare provider if you will be exposed to extreme hot or cold temperatures as well as to any insecticide poisons while taking Trilafon. This medication can make it harder for your body to sweat which increases your risk of developing heat stroke.

Tell your healthcare provider if you are pregnant or plan to become pregnant during treatment. Taking any antipsychotic medicine in the last 3 months of pregnancy could cause many issues in your newborn.

Ask your healthcare provider before breastfeeding while taking Trilafon because it may not be safe for you to do so.

Call your healthcare provider immediately if you develop any twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.

Avoid driving or performing any tasks that require alertness until you know how this medication will affect you. Trilafon could cause you to become dizzy or drowsy.

Avoid drinking alcohol while taking Trilafon because it can increase side effects of the medication.

Avoid direct exposure to sunlight or artificial UV rays such as tanning beds because Trilafon can make your skin burn more easily. Wear sunscreen and protective clothing while outside.

Some drugs can interact with Trilafon and cause unwanted side effects. Tell your healthcare provider about all the medicines you take, including over the counter medications, but especially any of the following:

  • Opioid medications
  • Sleeping pills
  • Muscle relaxers
  • Medicine to treat anxiety or seizures
  • Certain medications used to treat Parkinson’s disease (bromocriptine, levodopa, and more)
  • Anticholinergic medicines (dicyclomine, scopolamine, and some others)
  • Certain drugs that affect your liver enzymes (amiodarone, duloxetine, fluoxetine)

Form and Strength

This antipsychotic medication is available in the form of tablets.

Trilafon tablet strengths:

  • 2mg
  • 4mg
  • 8mg
  • 16mg

The Trilafon tablet strengths are all available in quantities of 100.


What precautions should be taken with Trilafon?

During treatment with Trilafon, you should avoid prolonged exposure to the sun or artificial UV rays because this medication can make your skin sunburn more easily. You should also avoid driving or performing hazardous tasks until you know if this medication will cause you to become dizzy or drowsy. Drinking alcohol can increase these adverse reactions and so should also be avoided during treatment.

What does Trilafon do to the brain?

Trilafon affects the chemicals and receptors in your brain to help bring balance to reduce symptoms of your psychotic disorders including schizophrenia and manic episodes of bipolar disorder. Thanks to these actions, Trilafon can decrease hallucinations, agitation, and restlessness. Follow all your healthcare provider’s instructions to ensure the best therapeutic results during treatment.



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