Safely Buy Trulance ( Plecanatide ) from Canada Prescriptions Plus.

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Formulation : Tablet
Drug Name Dosage Quantity Price Buy Now
Trulance 3mg 30 $167.30 Add To Cart
Trulance 3mg 90 $470.20 Add To Cart
Dosage: 3mg
Quantity: 30
Price: $167.30
Dosage: 3mg
Quantity: 90
Price: $470.20


Trulance (plecanatide) is a prescription medicine used in adults to treat irritable bowel syndrome with Constipation (IBS-C) and Chronic Idiopathic Constipation (CIC).

Trulance works by activating certain receptors in the intestine, which accelerates bowel movements and enhances the secretion of fluid into the bowel, making it easier to pass stools.

Plecanatide was approved by the U.S. Food and Drug Administration (FDA) in January 2017 for the treatment of CIC in adults. It is nearly identical to uroguanylin, a naturally occurring and endogenous human GI peptide.

Use and Dosage

Read the Medication Guide provided by your pharmacist before you start taking plecanatide and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

If you have trouble swallowing the tablet, you may crush the tablet and mix the powder into a teaspoonful of room-temperature applesauce. Swallow the mixture right away. Do not save the mixture for future use.

You may also place the tablet into a cup with an ounce (30 millilitres) of room-temperature water. Swirl the mixture for at least 10 seconds and then drink right away. If you see any part of the tablet left in the cup, add another ounce (30 millilitres) of water to the cup, swirl for 10 seconds and drink right away to get your whole dose.

The water mixture may also be given through a tube into the stomach (nasogastric or gastric tube). If you are giving this medication through a tube, ask your healthcare professional for detailed instructions on how to give it.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Side Effects

Common Side Effects include:

  • Diarrhea
  • Abdominal pain

Many of the adverse reactions caused by this oral drug are mild and temporary. If they worsen or persist, notify your healthcare provider.

Serious adverse effects include:

  • Severe diarrhea
  • Severe abdominal pain
  • Dehydration


Before you take Plecanatide, you should talk to your physician regarding your medical history. This prescription medication may not be suitable for patients with stomach or intestinal blockage history. Further, you should also discuss all prescription drugs, OTC drugs, herbal products, and food supplements you take because of possible interactions with this medication.

Pay close attention to any allergic reaction that you may experience while on this medication. Do not take this oral tablet if you have an allergy to Plecanatide or any of the inactive ingredients it may contain. Discontinue medication and seek emergency help once you notice signs of severe hypersensitivity.

Pregnant and nursing moms should talk to their doctors and discuss all the risks before using this prescription drug.

Form and Strengths

Trulance is available in the following form and strengths:

Trulance Tablet:

  • 3mg


How long after taking Trulance will I have a bowel movement?

This oral tablet is supposed to relieve constipation after a week of treatment. If it does not work after a week, you must talk to your healthcare provider about it.

How does Trulance work?

This Guanylate Cyclase-C Agonist works by elevating the concentrations of Cyclic Guanosine Monophosphate (cGMP), which stimulates the secretion of bicarbonate & chloride into the intestines. This leads to an increase in gastrointestinal fluid and acceleration of transit.

Should I take Trulance medication in the morning or at night?

You may take this prescription tablet any time of the day if you follow a dosing schedule. It works best if administered at the same time each day.

Does Trulance’s diarrhea go away?

Mild diarrhea usually happens after four weeks of taking this oral drug. Usually, this side effect does not persist and will eventually go away.



Additional information

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Quantities Available:

30, 90