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Xenical is a medication that is commonly used in the management of obesity. This includes both weight loss and weight maintenance, and Xenical is typically prescribed in conjunction with a reduced-calorie diet.

As a lipase inhibitor, its primary mechanism of action involves inhibiting the absorption of dietary fats. However, note that the use of Xenical must be accompanied by regular exercise, behavior change, and a disciplined diet program that has been approved by a physician.

Use and Dosage

If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this medication.

Take this medication as directed by your doctor, by mouth with liquid sometime during each meal that contains fat or within 1 hour after the meal, usually 3 times daily. If you miss a meal or your meal contains no fat, skip that dose of the medication. To decrease the chance of unpleasant side effects, no more than 30% of the calories in your diet must come from fat. Your daily intake of fat, protein, and carbohydrates should be evenly spread over 3 main meals.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Because this drug can interfere with the absorption of certain vitamins (fat-soluble vitamins including A, D, E, and K), a daily multivitamin supplement containing these nutrients is recommended. Take the multivitamin at least 2 hours before or 2 hours after taking orlistat (such as at bedtime).

If you take cyclosporine, take it at least 3 hours before or after orlistat to make sure the full dose of cyclosporine is absorbed into your bloodstream. If you take levothyroxine, take it at least 4 hours before or after orlistat.

You should see some weight loss within 2 weeks after you start Orlistat. Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Get emergency medical help if you have signs of an allergic reaction to Xenical: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Xenical and call your doctor at once if you have:

  • Severe stomach pain
  • Severe pain in your lower back
  • Blood in your urine, painful or difficult urination
  • Kidney problems – little or no urinating; swelling in your feet or ankles; feeling tired or short of breath
  • Liver problems – nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)

Common Xenical side effects include:

  • Oily or fatty stools
  • Oily spotting in your undergarments
  • Orange or brown colored oil in your stool
  • Gas and oily discharge
  • Loose stools, or an urgent need to go to the bathroom, inability to control bowel movements
  • An increased number of bowel movements
  • Stomach pain, nausea, rectal pain

This is not a complete list of side effects and others may occur.


You should not use Xenical if you are allergic to orlistat, or if you have malabsorption syndrome (an inability to absorb food and nutrients properly).

You also should not use this medicine if you have:

  • Gallbladder problems
  • If you are pregnant

Do not use Alli if:

  • You are not overweight
  • You have had an organ transplant
  • You use cyclosporine (to prevent organ transplant rejection)

To make sure Xenical is safe for you, tell your doctor if you have ever had:

  • Kidney stones
  • Gallbladder disease
  • Pancreatitis
  • Underactive thyroid
  • Liver disease
  • Kidney disease
  • An eating disorder (anorexia or bulimia)

Do not use Xenical if you are pregnant. Weight loss is not recommended during pregnancy, even if you are overweight. Stop taking Orlistat and tell your doctor right away if you become pregnant.

Taking Orlistat can make it harder for your body to absorb certain vitamins. These vitamins are important if you are nursing a baby. Do not use this medicine without a doctor’s advice if you are breastfeeding a baby.

Xenical is not approved for use by anyone younger than 12 years old. Do not give it to anyone under 18 years old.

Form and Strengths

Xenical is available in the following form and strengths:

Xenical Capsule:

  • 120 mg


What happens if I miss a dose?

Take the missed dose as soon as you remember, but no more than 1 hour after eating a meal. If it has been more than an hour since your last meal, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up for the missed dose.

What happens if I overdose?

Seek emergency medical attention.

What to avoid?

Avoid eating high-fat meals or you could have unpleasant side effects on your stomach or intestines.



Additional information

Brand Name:


Scientific Name:


Other Names:

Orlistat, Xenical



Quantities Available:

84, 168, 252