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Xyzal is an antihistamine medication used to treat allergic diseases such as allergic rhinitis and chronic idiopathic urticaria.

Levocetirizine is the active enantiomer of the antihistamine cetirizine dihydrochloride that blocks histamine receptors. This mechanism combined with several anti-inflammatory properties allows Xyzal to improve symptoms related to allergies, including skin reactions.

This antihistamine is well-tolerated with high bioavailability and fast onset of action. Xyzal has been found to be a safe and effective treatment for seasonal or perennial allergic rhinitis and chronic urticaria in both children and adults.

Uses and Dosage

The dose of Xyzal prescribed will vary depending on the individual and condition being treated. Always follow your doctor’s directives and read medical packaging labels carefully.

  • Swallow tablet whole
  • Take with or without food
  • Typically taken in the evening
  • Adults and children over 12 usually take 5mg once daily
  • Children 6 to 11 should take 2.5mg once a day
  • Children under 5 should take 1.25mg once daily
  • Do not take more than the recommended dose
  • Store at room temperature away from moisture and heat

Side Effects

Xyzal may cause some side effects to develop while it inhibits histamine production in your body. Speak with your doctor for more information regarding any symptoms you may develop when taking levocetirizine.

Common Xyzal side effects:

  • Drowsiness, tiredness
  • Sinus pain
  • Ear infection
  • Cough
  • Fever
  • Nosebleed
  • Vomiting, diarrhea, constipation
  • Dry mouth
  • Weight gain

Serious Side Effects

Some more serious side effects may occur when taking Xyzal. Stop using this antihistamine and call your doctor if you notice any of the following symptoms:

  • Worsening symptoms of allergies or urticaria
  • Painful or difficult urination
  • Little or no urination
  • Light-headed feeling, faintness
  • Fever
  • Signs of an ear infection (ear pain or full feeling, trouble hearing, drainage from ear, fussiness in a child)

Allergic Reactions

Do not take Xyzal if you are allergic to levocetirizine or cetirizine. If you develop signs of an allergic reaction, stop taking this medication and contact your doctor.

Xyzal allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling in face, tongue, lips, or throat


Avoid alcohol while using Xyzal because it can cause an increase in adverse side effects.

Avoid driving or performing any activity that requires alertness until you know how Xyzal will affect you; this medication could impair your thinking and reactions.

When giving Xyzal to children, ensure that you do not give them more than their prescribed dose. Children absorb twice the amount of levocetirizine than adults when taking the same dose.

Levocetirizine should not be used if you have end-stage kidney disease or if you are on dialysis. Children with kidney disease who are younger than 12 should not take Xyzal.

To ensure the safety of taking Xyzal, tell your doctor if you have ever had the following:

  • Kidney or liver disease
  • Urination problems
  • Gallbladder problems

Avoid taking Xyzal with other drugs that make you drowsy because this affect can worsen. Consult with your doctor before taking an opioid medication, sleeping pill, muscle relaxer, or medication for anxiety or seizures.

Some other medications may interact with levocetirizine and cause adverse effects. Tell your doctor about all the medications you take, including over the counter medicines, vitamins, and herbal products, but especially the following:

  • Ritonavir
  • Theophylline

Levocetirizine is not expected to harm an unborn baby if taken while pregnant. Tell your doctor if you become pregnant so they can monitor your symptoms.

Do not breastfeed while using this antihistamine medication.

Xyzal is not an approved treatment for any child younger than 6 months old.

Form and Strength

This antihistamine medication is available in tablet form.

Xyzal tablet strength:

  • 5mg in quantities of 100


Is Xyzal available over the counter?

You can use Xyzal Allergy 24HR without a prescription to alleviate symptoms related to allergies. If you have severe allergies or chronic urticaria, speak with a doctor to consider getting a prescription for Xyzal to best meet your needs.

How long does it take for Xyzal to start working?

Allergy or urticaria symptoms should begin to improve within an hour after taking the medication. Levocetirizine is easily absorbed and starts working quickly. Xyzol also has a long duration of action, meaning that it blocks histamine receptors long enough so the medication can be taken just once a day.



Additional information

Brand Name:


Scientific Name:


Other Names:

Levocetirizine, Vozet



Quantities Available:

30, 90, 100