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Zanaflex is a prescription medication utilized to address muscle spasms brought on by conditions such as multiple sclerosis or spinal cord injury.

Tizanidine, the active ingredient in Zanaflex, is a centrally acting muscle relaxant that blocks nerve impulses sent to the brain.

Before beginning treatment with Zanaflex, discuss your medical history and current medications with your healthcare provider to avoid drug interactions or contraindications.

Use and Dosage

Take this medication by mouth as directed by your doctor, usually every 6 to 8 hours.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully. Do not take more than 36 milligrams a day or more than 3 doses in 24 hours.

Your body will absorb this medication differently depending on whether you take it as a tablet or capsule, whether you take it with food or on an empty stomach, or if you sprinkle the contents of the capsule on food. Be sure to discuss with your doctor how to take this medication to determine the best way to take your dose, especially when changes to your dose are being considered or if your doctor prescribes a different form of tizanidine (such as a tablet or capsule).

If you suddenly stop using this medication, you may have withdrawal symptoms (such as anxiety, tremor, increased blood pressure/heart rate/muscle tenseness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used tizanidine for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

Side Effects

Get emergency medical help if you have signs of an allergic reaction to Zanaflex: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • A light-headed feeling, like you might pass out
  • Weak or shallow breathing
  • Confusion, hallucinations
  • Yellowing of the eyes or skin
  • Pain or burning when you urinate

Common Zanaflex side effects may include:

  • Drowsiness, dizziness, weakness
  • Dry mouth
  • Feeling nervous
  • Blurred vision
  • Flu-like symptoms
  • Abnormal liver function tests
  • Runny nose, sore throat
  • Urination problems, painful urination
  • Vomiting, constipation
  • Uncontrolled muscle movements

This is not a complete list of side effects and others may occur.


Before taking tizanidine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of low blood pressure, kidney disease, and liver disease.

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially dizziness and drowsiness. These effects can increase the risk of falling.

During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Form and Strengths

Zanaflex is available in the following form and strengths:

  • Zanaflex Tablet:
    • 2 mg
  • Tizanidine Tablet:
    • 2 mg
    • 4 mg


What happens if I miss a dose?

Take the medicine as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention.

Overdose symptoms may include weakness, drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, or fainting.

What to avoid?

Do not use Zanaflex at a time when you need muscle tone for safe balance and movement during certain activities. In some situations, it may be dangerous for you to have reduced muscle tone. Drinking alcohol with this medicine can cause side effects.



Additional information

Brand Name:


Scientific Name:


Other Names:

Sirdalud, Tizan, Tizanidine


2mg, 4mg

Quantities Available:

60, 90, 100