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Zaroxolyn is a diuretic medication used to treat edema (fluid retention) in those with congestive heart failure as well as kidney disorders like nephrotic syndrome. This medication is also used to treat hypertension (high blood pressure).

Metolazone is a thiazide diuretic that inhibits the transport and reabsorption of sodium in your kidneys while increasing your body’s excretion of sodium, chloride, and water. Thanks to these actions, Zaroxolyn is able reduce fluid retention and offer an antihypertensive effect.

Dosage and Administration

The dose of Zaroxolyn that is prescribed will vary depending on the individual and condition being treated. Follow all your healthcare provider’s directions for use and read packaging instructions to ensure the best therapeutic response during your treatment. Do not change your dose without speaking with your healthcare provider.

  • Swallow tablets whole
  • Take at the same time each day
  • Can be taken with or without food
  • Take your Zaroxolyn doses at least 4 hours before going to bed to avoid having to wake in the middle of the night to urinate
  • If you take cholestyramine, wait at least 4 hours before or after your Zaroxolyn dose to use it
  • If you use colestipol, take the medication at least 2 hours before or after your Zaroxolyn dose
  • Tell your healthcare provider if your condition does not improve or if it worsens
  • If using for hypertension, continue taking Zaroxolyn as prescribed even if you feel well
  • Store at room temperature away from children and pets

To treat edema:

  • Most adults start treatment by taking 5 to 10mg once daily
  • Adults with edema due to kidney disease should take 20mg once a day
  • Doses can increase gradually as needed and tolerated
  • Maintenance doses should be the lowest dose necessary for results

To treat hypertension:

  • Adults should start by taking 2.5 to 5mg once a day
  • Doses can increase as needed

Side Effects

Zaroxolyn may cause some side effects to develop while increasing the amount of sodium, chloride, and water you excrete in your urine. Talk to your healthcare provider to learn more about any symptoms that you may encounter.

Common Zaroxolyn side effects:

  • Dizziness, spinning sensation
  • Drowsiness, tiredness
  • Depressed mood
  • Muscle or joint pain
  • Numbness or tingling
  • Nausea, stomach pain, decreased appetite
  • Diarrhea, constipation

Serious Side Effects

Some more serious adverse reactions may occur during treatment with Zaroxolyn. Contact your healthcare provider if you develop any of the following side effects:

  • Chest pain
  • Pounding heart or fluttering sensation in your chest
  • Easy bruising or bleeding
  • Light-headedness, feeling faint
  • Liver problems (nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-coloured stool, jaundice)
  • Low potassium levels (leg cramps, constipation, irregular heartbeat, fluttering sensation in your chest, increased thirst or urination, numbness, tingling, muscle weakness, limp muscle feeling)
  • Low sodium levels (headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady)
  • Signs of an electrolyte imbalance (dry mouth, nausea, vomiting, weakness, drowsiness, lack of energy, muscle pain, little or no urination, feeling restless)
  • Severe skin reaction (fever, sore throat, swollen face or tongue, burning eyes, skin pain, red or purple rash, blistering or peeling skin)

Allergic Reactions

Do not take Zaroxolyn if you are allergic to metolazone. Call your healthcare provider right away if you develop any of the following signs of an allergic reaction:

  • Hives
  • Trouble breathing
  • Swollen face, lips, tongue, or throat


  • Do not use Zaroxolyn if you have severe liver disease or if you are unable to urinate.
  • To ensure your safety when taking this medication, tell your healthcare provider if you have any of the following:
    • Electrolyte imbalance
    • Heart rhythm disorder
    • Sulfa drug allergy
    • Liver or kidney disease
    • Diabetes
    • Gout
    • Systemic lupus erythematosus
  • Tell your healthcare provider if you are pregnant or as soon as you become pregnant while taking Zaroxolyn. This medication may cause your newborn to develop side effects such as blood cell problems or jaundice.
  • Do not breastfeed while taking Zaroxolyn because it can pass into your breastmilk and affect your nursing child.
  • Some drugs may interact with Zaroxolyn and cause adverse reactions. Tell your healthcare provider about all the medicines you take, including over the counter medications, but especially any of the following:
    • Any other blood pressure medication
    • Digoxin, digitalis
    • Other diuretic medicines like furosemide
    • Insulin or oral diabetes medications
    • Lithium
    • Methenamine
    • High doses of vitamin D
    • Blood thinner like warfarin
    • nonsteroidal anti-inflammatory drugs like ibuprofen, celecoxib, or naproxen
    • Salicylates such as aspirin, Pepto-Bismol, or trilisate
    • Steroid medicines like prednisone
  • Ask your healthcare provider before using any medications that can cause you to become light-headed because they can worsen this effect caused by Zaroxolyn. These medications include narcotic pain medicine, muscle relaxants, or medications for anxiety or seizures.
  • Do not drink alcohol during treatment with Zaroxolyn because it can cause an increase in adverse effects.
  • Avoid becoming overheated or dehydrated while exercising, out in hot weather, or by not drinking enough water.
  • Follow your healthcare provider’s advice regarding what to drink and how much because too much liquid could be as dangerous as not having enough.
  • Zaroxolyn is not an approved treatment for anyone under the age of 18.

Form and Strength

This diuretic medication is available in tablet form.

  • Zaroxolyn tablet strengths:
    • 2.5mg
    • 5mg

The 2.5mg Zaroxolyn tablets are available in quantities of 100 while the 5mg tablets are available in quantities of 90.


When is the best time of day to take Zaroxolyn?

You can take Zaroxolyn any time of day without losing efficacy of the medication, but you should take your daily dose at least 4 hours before your bedtime. Doing this helps avoid you having to get up in the middle of the night to urinate due to the medicine’s diuretic effect. Also ensure that you take your dose of Zaroxolyn at the same time each day for the best results.

What to avoid when taking Zaroxolyn?

During treatment with Zaroxolyn, you should avoid drinking alcohol because it can cause an increase in adverse reactions. You should also avoid becoming overheated during exercise or in hot temperatures and drink an adequate amount of liquids to ensure you do not become dehydrated. Follow all your healthcare provider’s instructions when taking Zaroxolyn to ensure the best therapeutic results.



Additional information

Brand Name:


Scientific Name:


Other Names:

Zaroxolyn, Zytanix


2.5mg, 5mg

Quantities Available:

90, 100