Safely Buy Zestoretic ( Lisinopril/HCTZ ) from Canada Prescriptions Plus.

( Top Brand Option )


Prescription Required
Formulation : Tablet
Drug Name Dosage Quantity Price Buy Now
Zestoretic 20/12.5mg 84 $108.20 Add To Cart
Zestoretic 20/25mg 100 $166.65 Add To Cart
Dosage: 20/12.5mg
Quantity: 84
Price: $108.20
Dosage: 20/25mg
Quantity: 100
Price: $166.65

( Affordable Generic Alternatives )


Prescription Required
Formulation : Tablet
Drug Name Dosage Quantity Price Buy Now
Lisinopril/Hctz 10/12.5mg 100 $66.25 Add To Cart
Lisinopril/Hctz 20/25mg 90 $75.75 Add To Cart
Lisinopril/Hctz 20/12.5mg 100 $36.50 Add To Cart
Dosage: 10/12.5mg
Quantity: 100
Price: $66.25
Dosage: 20/25mg
Quantity: 90
Price: $75.75
Dosage: 20/12.5mg
Quantity: 100
Price: $36.50


Zestoretic is an antihypertensive medication used to treat high blood pressure (hypertension) and reduce your risk of a heart attack or stroke.

This medication combines lisinopril, an angiotensin converting enzyme (ACE) inhibitor, with hydrochlorothiazide, a thiazide diuretic. The lisinopril is used to lower your blood pressure by inhibiting certain enzymes that affect your cardiovascular health while also relieving symptoms of fluid retention. Hydrochlorothiazide increases the amount of sodium your body excretes through your urine to reduce the amount you absorb. These actions help manage and control your blood pressure while helping protect your cardiovascular health.

Dosage and Administration

The dose of Zestoretic that you are prescribed will vary depending on the individual being treated. Follow all your healthcare provider’s instructions and read packaging labels carefully to ensure the best results during treatment. Do not change your dose on your own.

  • Swallow tablets whole
  • Take with or without food at the same time each day
  • Take in the morning or at least 4 hours before bed if it causes you to urinate more frequently
  • If you take cholesterol-lowering drugs, use Zestoretic at least 4 hours before or after
  • Most adults take 10/12.5mg or 20//12.5mg once daily
  • If you were previously using lisinopril monotherapy, your dose of lisinopril may be reduced when adding the diuretic
  • If you were previously being treated with a diuretic, you may need to stop taking it for 2 to 3 days before starting treatment with Zestoretic
  • Doses can increase every 2 to 3 weeks as needed to gain blood pressure control
  • Adults should not take more than 50mg hydrochlorothiazide and 80mg lisinopril a day
  • Continue taking Zestoretic as prescribed even if you feel well
  • Store at room temperature away from children and pets

Side Effects

Zestoretic may cause you to develop some side effects while affecting your blood pressure and sodium levels. Speak with your healthcare provider to learn more about any symptoms that you may encounter during treatment.

Common Zestoretic side effects:

  • Cough
  • Headache
  • Dizziness
  • tiredness

Serious Side Effects

Some more serious side effects may occur during treatment with Zestoretic. Call your healthcare provider right away if you develop any of the following symptoms:

  • Light-headedness, feeling faint
  • Eye pain, problems with your vision
  • Little or no urination
  • Weakness, drowsiness, feeling restless
  • Fever, chills, sore throat, mouth sores, difficulty swallowing
  • Jaundice
  • High potassium (nausea, tingling, chest pain, irregular heartrate, loss of movement)
  • Low pottasium (leg cramps, constipation, irregular heartbeats, fluttering sensation in your chest, increased thirst or urination, numbness or tingling, muscle weakness, limp-feeling)
  • Low sodium (headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady)

Allergic Reactions

Do not take Zestoretic if you are allergic to lisinopril, hydrochlorothiazide, or any of the other tablet ingredients. Contact your healthcare provider if you notice any of the following signs of an allergic reaction:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


  • Do not take Zestoretic if you are pregnant. Tell your healthcare provider right away if you become pregnant while taking this medication because it can cause serious harm to your unborn baby if taken during the second or third trimesters of pregnancy.
  • Do not use Zestoretic if you have ever had angioedema or if you are unable to urinate.
  • Do not take Zestoretic within 36 hours of taking any medicine that contains sacubitril.
  • If you have diabetes, do not use Zestoretic with any medicine that contains aliskiren.
  • If you have a sulfa drug allergy or have ever reacted to taking an ACE inhibitor, do not use Zestoretic.
  • To ensure your safety when taking Zestoretic, tell your healthcare provider if you have ever had any of the following conditions:
    • Kidney disease
    • Cirrhosis or another liver disease
    • Glaucoma
    • Heart disease or congestive heart failure
    • Asthma or allergies
    • Gout
    • Lupus
    • Sulfa drug or penicillin allergy
    • If you follow a low-salt diet
  • Do not breastfeed while taking Zestoretic.
  • Some drugs may interact with Zestoretic and cause unwanted effects. Tell your healthcare provider about all the medicines you take, including over the counter medications, but especially any of the following:
    • Any other blood pressure medicine
    • Lithium
    • Everolimus, sirolimus, temsirolimus
    • Nonsteroidal anti-inflammatory drugs such as aspirin, ibuprofen, or naproxen
    • Aliskiren
    • Dofetilide
    • Losartan, valsartan
    • Birth control pills that contain drospirenone
    • Sacubitril
  • Avoid direct exposure to sunlight and artificial UV rays while taking Zestoretic because it can increase your risk of developing skin cancer. Use sunscreen and wear protective clothing while you are outside.
  • Avoid drinking alcohol during treatment because it can lower your blood pressure and increase side effects.
  • Do not use potassium supplements or salt substitutes while takin Zestoretic unless directed to do so by your healthcare provider because it can lead to electrolyte imbalances.
  • Avoid becoming overheated or dehydrated during treatment with Zestoretic.
  • Avoid driving or performing any tasks that require alertness until you know how this medication will affect you. Zestoretic may cause you to become drowsy or dizzy which can impair your reactions.
  • Zestoretic is not an approved treatment method for anyone under the age of 18.

Form and Strength

This antihypertensive medicine is available in the form of tablets.

  • Zestoretic tablet strengths:
    • 10mg lisinopril/12.5mg hydrochlorothiazide
    • 20/12.5mg
    • 20/25mg

Each Zestoretic tablet strength is available in quantities of 100 while the 20/12.5mg ones are also available in groups of 84 and the 20/25mg tablets are available in quantities of 90.


What to avoid when taking Zestoretic?

Avoid drinking alcohol during treatment with Zestoretic because it causes your blood pressure to drop to dangerous levels and can increase adverse effects. During treatment you should also avoid driving or performing hazardous tasks until you know whether the medication impairs your reactions by making you dizzy or drowsy.

What time of day should I take Zestoretic?

Zestoretic can be taken at any time of day without significantly reducing the drug’s efficacy, but many healthcare providers recommend taking your daily dose in the morning. If the medication causes you to urinate more frequently, you should take your dose at least 4 hours before going to bed to prevent waking up to urinate.



Additional information

Brand Name:


Scientific Name:

Lisinopril/HCTZ, Lisinopril/Hctz

Other Names:

Lisinopril/Hctz, Lisinopril Hct, Lisinopril Hctz, Zestoretic


10/12.5mg, 20/12.5mg, 20/25mg

Quantities Available:

84, 90, 100