Safely Buy Ziac ( Bisoprolol/Hctz ) from Canada Prescriptions Plus.

We don't sell this generic-version medication.

( Top Brand Option )


Prescription Required
Formulation : Tablet
Drug Name Dosage Quantity Price Buy Now
Ziac 5/6.25mg 30 $41.00 Add To Cart
Ziac 5/6.25mg 90 $105.00 Add To Cart
Dosage: 5/6.25mg
Quantity: 30
Price: $41.00
Dosage: 5/6.25mg
Quantity: 90
Price: $105.00


Ziac is a combination antihypertensive medication used to treat high blood pressure (hypertension).

This medication combines bisoprolol, a beta-blocker, with hydrochlorothiazide, a thiazide diuretic, to control your blood pressure levels. Bisoprolol blocks chemicals in your body that affect your heart and blood vessels to lower your heart rate, blood pressure, and cardiac strain. Hydrochlorothiazide increases the amount of sodium that passes through your urine. These actions support proper blood pressure levels and cardiac health.

Dosage and Administration

The Dose of Ziac that is prescribed will vary depending on the individual being treated. Follow all instructions offered by your healthcare provider and read packaging labels carefully to ensure the best therapeutic response during treatment.

  • Swallow tablets whole
  • Take once a day with or without food
  • Most adults start treatment by taking 2.5mg of bisoprolol and 6.25mg of hydrochlorothiazide
  • Doses can increase every 2 weeks up to the maximum dose of 20/12.5mg
  • Maintenance doses can range from 2.5 to 20mg of bisoprolol with 6.25 to 25mg of hydrochlorothiazide
  • Do not suddenly stop taking Ziac
  • Continue taking Ziac as prescribed even if you feel well
  • Store at room temperature away from children and pets

Side Effects

Ziac may cause some side effects to develop while affecting your cardiovascular system. Speak with your healthcare provider to learn more about any reactions you may experience during treatment with Ziac.

Common Ziac side effects:

  • Dizziness
  • Weakness, tiredness
  • Diarrhea, nausea, indigestion
  • Headache
  • Cough

Serious Side Effects

Some more serious adverse reactions may occur during treatment with Ziac. Contact your healthcare provider right away if you develop any of the following symptoms:

  • Chest pain
  • Fast, slow, or uneven heartbeats
  • Light-headedness, feeling faint
  • Blurred or tunnel vision, eye pain, seeing halos around lights
  • Shortness of breath, swelling, rapid weight gain
  • Liver problems (nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-coloured stools, jaundice)
  • Electrolyte imbalance (increased thirst or urination, constipation, muscle pain, weakness, leg cramps, numbness, tingling, feeling jittery, irregular heartbeats, fluttering in your chest, choking feeling)
  • Low blood sugar (headache, hunger, sweating, irritability, dizziness, fast heart rate, feeling anxious or shaky)

Allergic Reactions

Do not use Ziac if you are allergic to bisoprolol, hydrochlorothiazide, or sulfa drugs. Stop using this medication and call your healthcare provider if you notice any of the following symptoms of an allergic reaction:

  • Hives
  • Trouble breathing
  • Swelling face, lips, tongue, or throat
  • Fever
  • Sore throat
  • Burning eyes, skin pain
  • Red or purple rash
  • Blistering or peeling skin


  • Do not use Ziac if you are unable to urinate or any of the following conditions:
    • Serious heart condition including sick sinus syndrome
    • Severe heart failure
    • Slow heartbeats that cause you to faint
    • Sulfa drug allergy
  • To ensure your safety when taking Ziac, tell your healthcare provider if you have ever had any of the following:
    • Congestive heart failure
    • Asthma or another breathing disorder
    • Diabetes
    • Thyroid disorder
    • Glaucoma
    • Peripheral vascular disease like Raynaud’s syndrome
    • Kidney disease
    • Liver disease
    • Lupus
    • Gout
    • Sulfa drug or penicillin allergy
  • Carefully check your blood sugar levels if you are diabetic while taking Ziac because the medication can make it more difficult to tell when your glucose levels are low.
  • Ziac can make it easier for you to become dehydrated or overheated during treatment. Make sure you drink an adequate amount of liquids and avoid becoming too hot during exercise or in hot weather.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant while using Ziac. It is unclear how the medication may affect your unborn baby.
  • Do not breastfeed while taking Ziac.
  • Avoid drinking alcohol during treatment with Ziac because it can cause an increase in adverse reactions and make your blood levels drop too low.
  • Ziac may increase your risk of developing skin cancer; avoid direct exposure to the sun and artificial UV rays during treatment.
  • Move slowly when standing from a seated or laying position to avoid becoming dizzy.
  • Some drugs may interact with Ziac and cause unwanted side effects. Tell your healthcare provider about all the medications you take, including over the counter medicines, but especially any of the following:
    • Colestipol or cholestyramine
    • Insulin or oral diabetes medicine
    • Lithium
    • Sedative or narcotic medications
    • Heart or other blood pressure medicine (clonidine, digoxin, diltiazem, and others)
    • Nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen, and more)
    • Steroid medicines like prednisone
  • Ziac is not an approved treatment for anyone under the age of 18.

Form and Strengths

This combination antihypertensive medication is available in tablet form.

  • Ziac tablet strength:
    • 5mg bisoprolol/6.25mg hydrochlorothiazide

The 5/6.25mg Ziac tablets are available in quantities of 30 and 90.


Can you drink alcohol while taking Ziac?

During treatment with Ziac, you should avoid drinking alcohol because it can cause an increase in adverse reactions.

Alcohol can also cause your blood pressure to drop, when combined with Ziac this can cause you to have dangerously low levels of blood pressure. Follow all your healthcare provider’s instructions for how much you can drink.

Why can’t I take Ziac at night?

Ziac is normally recommended to be taken in the morning because it can cause you to pass urine more frequently which can interrupt your sleep if taken too close to bedtime. However, your healthcare provider may recommend that you take your daily dose in the evening if it causes you to become dizzy. Take this medication exactly as prescribed by your healthcare provider for the best results.



Additional information

Brand Name:


Scientific Name:


Other Names:




Quantities Available:

30, 90