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Formulation : Capsule
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Zonisamide is a medication used to treat epilepsy and Parkinson’s disease. It is marketed under the brand name Zonegran among others.

Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. The exact mechanisms by which zonisamide works to prevent seizures are not fully understood.

Follow the specific dosing instructions provided by your healthcare provider.

Use and Dosage

Read the Medication Guide provided by your pharmacist before you start taking zonisamide and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually 1 to 2 times a day. To prevent kidney stones from forming, drink plenty of liquids while taking this medication unless your doctor instructs you otherwise.

If you are using the capsule form of this medication, swallow the capsules whole.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Shake the bottle well before each dose.

Dosage is based on your medical condition and response to treatment. It is very important to follow your doctor’s dosing instructions exactly. Your doctor will start you on a low dose and slowly increase your dose. It may take several weeks or months to reach the best dose for you and to get the full benefit from this medication.

Use this medication regularly to get the most benefit from it. This drug works best when the amount of medicine in your body is kept at a constant level. To help you remember and to keep a constant level, take zonisamide at the same time(s) each day.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Common side effects include:

  • Drowsiness
  • Dizziness
  • Lightheadedness
  • Headache
  • Nausea
  • Fatigue
  • Insomnia or trouble sleeping
  • Lack of coordination
  • Loss of appetite
  • Diarrhea
  • Blurred vision
  • Double vision

Severe side effects include:

  • Mental or mood problems
  • Decreased sweating
  • Speech problems
  • Sudden abdominal pain
  • Painful urination
  • Bleeding
  • Eye pain
  • Change in urine output
  • Symptoms of metabolic acidosis (bone pain, irregular heartbeat, severe drowsiness)
  • Depression or suicidal thoughts

This is not a complete list of Zonegran side effects.


Before taking this oral anticonvulsant, you must fully disclose your medical history to your physician, especially lung or breathing problems, metabolic imbalance, long-term diarrhea, kidney disease, liver disease, or mental problems. Certain medical conditions or disorders may impact how you will respond to Zonegran. You also must talk about all the prescription drugs and nonprescription drugs you are taking as they may have drug interactions with zonisamide.

Be watchful for any signs of an allergic reaction while on this treatment. Avoid taking Zonegran if you have a known allergy to zonisamide or any inactive ingredients each capsule may contain. Signs of hypersensitivity are breathing difficulty, swelling of the face, skin rash, hives, and severe dizziness. Discontinue medication and seek emergency help when this occurs.

Among the adverse reactions of this drug are drowsiness, dizziness, lightheadedness, and visual changes. Practice extreme caution when driving, using machinery, or doing any activities that require clear vision and alertness. Avoid alcoholic beverages or any substances that may trigger or worsen the side effects.

You are more likely to suffer from heatstroke when taking this medication because of decreased sweating. To prevent this, avoid hot tubs, and saunas, and do strenuous activities in hot weather. Wear light clothes and stay hydrated, as well.

Zonegran may cause depression and could lead to suicidal tendencies. Be watchful of the warning signs of suicide and report it right away. Signs of suicide are talking about dying, changes in behaviour, hopelessness, and changes in sleeping patterns.

Note that this anticonvulsant could cause harm to pregnant women. It could result in possible congenital anomalies. This is also known to pass into the breast milk.

Form and Strengths

Zonegran is available in the following form and strengths:

Zonisamide Capsule:

  • 25 mg
  • 50 mg
  • 100 mg


Can I use this medication for migraine?

Physicians use this medication to manage migraines.

Could this medication cause weight loss?

Zonegran & weight loss are correlated. This medication could cause weight loss.

Does this medication cause hair loss?

There is no direct correlation between Zonegran & hair loss.



Additional information

Brand Name:


Scientific Name:


Other Names:

Zonegran, Zonisep


25mg, 50mg, 100mg

Quantities Available:

56, 100, 112


Capsule, Tablet