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Zyloprim, which contains the active ingredient allopurinol, is an oral medication used to treat gout and kidney stones.

Allopurinol works to reduce the synthesis of uric acid in the body, which is responsible for causing gout and the formation of kidney stones.

Your physician can assess if allopurinol is the appropriate choice for your medical needs.

Use and Dosage

Take this medication by mouth as directed by your doctor, usually once daily. Take this medication after a meal to reduce stomach upset. If your dose is more than 300 milligrams a day, you will need to take several smaller doses during the day to get this amount (ask your doctor for directions).

It is best to drink a full glass of water with each dose and at least 8 more glasses (8 ounces each) of fluid a day. If your doctor has directed you to drink less fluid for other medical reasons, consult your doctor for further instructions. Your doctor may also instruct you on how to decrease acid in your urine (such as avoiding large amounts of ascorbic acid/vitamin C).

Dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

For the treatment of gout, it may take up to several weeks for this medicine to have an effect. You may have more gout attacks for several months after starting this medicine while the body removes extra uric acid. Allopurinol is not a pain reliever. To relieve pain from gout, continue to take your prescribed medicines for gout attacks (such as colchicine, ibuprofen, and indomethacin) as directed by your doctor.

Side Effects

Get emergency medical help if you have signs of an allergic reaction to allopurinol (hives, difficulty breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Allopurinol may cause serious side effects. Stop using this medicine and call your doctor at once if you have:

  • Any skin rash, no matter how mild
  • Painful urination, blood in the urine
  • Inflammation of your blood vessels – numbness or tingling, skin rash, fever, headache, body aches, night sweats, weight loss, feeling weak or tired
  • Signs of infection – fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding
  • Liver problems – loss of appetite, weight loss, stomach pain (upper right side), itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)

Common allopurinol side effects include:

  • An increase in gout attacks when you first start taking this medicine
  • Rash
  • Drowsiness
  • Abnormal liver function tests
  • Nausea, vomiting, diarrhea
  • Kidney problems – swelling, urinating less, feeling tired or short of breath

This is not a complete list of side effects and others may occur.


Before taking allopurinol, tell your doctor or pharmacist if you are allergic to it; if you have had a severe reaction to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of liver disease, kidney disease, diabetes, high blood pressure (hypertension), and unusual diets (such as fasting).

This drug may make you drowsy. Alcohol or marijuana (cannabis) can make you drowsier. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Alcohol may also decrease the effectiveness of this drug. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.

Allopurinol passes into breast milk. Consult your doctor before breastfeeding.

Form and Strengths

Zyloprim is available in the following form and strengths:

  • Zyloprim Tablet:
    • 200 mg
    • 300 mg
  • Allopurinol Tablet:
    • 100 mg
    • 200 mg
    • 300 mg


What happens if I miss a dose?

Take allopurinol as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Call your doctor for instructions if you miss an appointment for your allopurinol injection.

What happens if I overdose?

Seek emergency medical attention.

What should I avoid while using allopurinol?

Avoid driving or hazardous activity until you know how allopurinol will affect you. Your reactions could be impaired. Avoid drinking alcohol.



Additional information

Brand Name:


Scientific Name:


Other Names:

Allopurinol, Zyloprim, Zyloric


100mg, 200mg, 300mg

Quantities Available:

84, 100, 200