Frontline Plus for Large Dog

Formulation : Pipettes
Dosage : 45-88lb (20-40kg)
Quantity : 3
Prescription Not Required
(All Prices in USD)


Frontline Plus for Large Dogs is a flea and tick treatment specifically designed for dogs weighing between 20 and 40 kilograms (44 to 88 pounds).

Frontline Plus for Large Dogs is a fast-acting and long-lasting waterproof solution that helps protect your dog from fleas, ticks, and other parasites.

The active ingredients in Frontline Plus include fipronil and (S)-methoprene, which work together to kill adult fleas and ticks and inhibit the growth of flea eggs and larvae.

Use and Dosage

The dosage and usage instructions for Frontline Plus for Large Dogs are as follows:

  • Make sure your dog is at least 8 weeks old and weighs between 45-88 pounds (20-40 kilograms).
  • Remove one applicator from the package. The applicator contains the correct dosage for a single treatment.
  • Hold the applicator upright and snap the tip to open it.
  • Part your dog’s fur between the shoulder blades, exposing a small area of skin.
  • Place the applicator tip against the skin and squeeze it gently to apply the solution directly onto the skin.
  • Avoid getting the solution in your dog’s eyes or mouth. If contact occurs, rinse thoroughly with water.
  • Allow the treated area to dry completely before touching or grooming your dog.
  • Avoid bathing your dog or letting it swim for at least 24 hours after application.
  • Reapply Frontline Plus every 30 days for continuous protection against fleas and ticks.

Follow the instructions carefully and use the correct dosage for your dog’s weight. Using Frontline Plus for Large Dogs on a cat or using a higher dosage than recommended can lead to overdosing and potential health risks. If you have any concerns about dosage or usage, it is best to consult with your veterinarian for personalized advice.

Side Effects

Frontline Plus for Large Dogs (fipronil/methoprene) may have side effects in some cases. While it is considered safe when used as directed, there have been reports of potential side effects.

Some potential side effects of Frontline Plus for Dogs may include:

  • Skin irritation: Occasional reports of skin irritation and redness at the application site have been observed. If your dog shows signs of skin irritation, such as excessive itching, redness, or swelling, it is recommended to bathe the pet with mild soap and large amounts of water.
  • Allergic reactions: Although uncommon, some dogs may be allergic to the active ingredients in Frontline Plus. Signs of an allergic reaction may include itching, swelling, hives, or difficulty breathing. If your dog exhibits any signs of an allergic reaction, discontinue use immediately and consult with your veterinarian.
  • Neurological effects: In rare instances, dogs may experience neurological effects such as tremors, shaking, or uncoordinated movements. If you notice any unusual behaviour or neurological symptoms in your dog after applying Frontline Plus, contact your veterinarian promptly.

Closely monitor your dog after applying any flea and tick medication and consult with your veterinarian if you have any concerns or if side effects persist or worsen.


While generally safe and effective when used according to the instructions, there are a few cautions and precautions to keep in mind when using this product:

  • Suitable for dogs only: Frontline Plus for Large Dogs is specifically formulated for dogs and should not be used on other animals, such as cats or rabbits. Using dog-specific medications on cats or other animals can cause serious problems.
  • Age restrictions: Frontline Plus for Large Dogs is suitable for dogs and puppies that are 8 weeks of age or older. Follow the age restrictions specified on the product packaging and consult with a veterinarian if you have any questions or concerns.
  • Dosage: apply the correct dosage of Frontline Plus for Large Dogs based on the weight of your dog. The product packaging provides guidance on the appropriate dosage for dogs of different weights. Using the correct dosage ensures optimal effectiveness and minimizes the risk of adverse effects.
  • Consult a veterinarian: If your dog has any known allergies, sensitivities, or underlying health conditions, consult with a veterinarian before using Frontline Plus for Large Dogs or any other flea and tick treatment. They can guide you on the suitability of the product for your dog’s specific needs.
  • Adverse effects: While rare, some dogs may experience adverse effects from Frontline Plus for Large Dogs. These can include skin irritation at the application site, itchiness, redness, or hair loss. If you notice any unusual or concerning symptoms after applying the product, discontinue use and consult with a veterinarian.
  • Storage and disposal: store Frontline Plus for Large Dogs in a cool, dry place and away from children and pets. Dispose of any unused product and packaging according to the instructions provided on the packaging or consult with local waste disposal authorities.

Form and Strengths

Frontline Plus for Large Dog is available in the following form and strengths:

  • Fipronil/Methoprene Pipettes:
    • between 45 to 88 lbs or between 20-40kg


How often should I apply Frontline Plus to my dog?

Frontline Plus is typically applied once a month. However, the frequency of application may vary depending on factors such as the severity of the flea or tick infestation and your dog’s lifestyle.

Is Frontline Plus safe for my dog?

Frontline Plus is considered safe for use on dogs when applied according to the instructions. However, as with any medication, there is a small risk of adverse reactions.

Can Frontline Plus be used on puppies?

Frontline Plus is labelled for use on puppies as young as 8 weeks old and weighing at least 5 pounds. Choose the appropriate formulation based on your puppy’s weight and consult with your veterinarian before using any flea and tick treatment on a young puppy.

Does Frontline Plus protect against all types of ticks?

Frontline Plus is effective against varied species of ticks, including the common ones like deer ticks, American dog ticks, and brown dog ticks. However, it may not provide complete protection against all tick species, especially in areas where certain tick species are prevalent. Check for ticks on your dog after outdoor activities and consult with your veterinarian about additional tick prevention strategies if needed.



Additional information

Brand Name:

Frontline Plus for Large Dog

Scientific Name:

Fipronil/methoprene – non Rx

Other Names:

Frontline Plus Purple for Large Dog


45-88lb (20-40kg)

Quantities Available: