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Prescription Required
Formulation : Tablet
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Prescription Required
Formulation : Tablet
Drug Name Dosage Quantity Price Buy Now
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This medication contains 2 medicines: atovaquone and proguanil. It is used to prevent and treat malaria caused by mosquito bites in countries where malaria is common.

Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells and other tissues.

In some cases, you may need to take a different medication (such as primaquine) to complete your treatment. Both medications may be needed for a complete cure and to prevent the return of infection (relapse). Atovaquone/proguanil belongs to a class of drugs known as antimalarials.

Use and Dosage

Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication, and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.

Take this medication by mouth with food or a milky drink (such as whole milk, milkshake) that contains fat. If you vomit within 1 hour of taking a dose, repeat the dose. If you have vomiting that does not stop after taking atovaquone/proguanil, contact a doctor right away. You may need another medication to prevent vomiting or a different malaria medication.

Swallow the tablet whole because of its bitter taste. Do not chew. If you have trouble swallowing tablets, this medication may be crushed and mixed with condensed milk. Take the entire mixture right away. Do not save for future use.

Dosage is based on your medical condition, on whether you are preventing or treating the illness, and your response to treatment. Dosage in children is also based on weight.

To prevent illness, take atovaquone/proguanil as directed by your doctor, usually once daily. Start this medication 1 to 2 days before you enter the malarious area and continue taking the medication while in the area and for 7 days after leaving.

If needed, primaquine can be taken for 14 days starting during the last week of treatment with atovaquone/proguanil or starting immediately after you have finished treatment.

To treat malaria, take this medication as directed by your doctor, usually once daily for 3 days.

Continue taking this medication exactly as prescribed by your doctor. To help you remember, take it at the same time each day for the entire prescribed time.

Do not take more or less of this drug than prescribed. Do not stop taking this drug before completing the full treatment unless directed to do so by your doctor, even if you feel better or do not feel sick. Skipping or changing your dose without approval from your doctor may cause prevention/treatment to be ineffective, because the amount of parasite to increase, make the infection more difficult to treat (resistant), or worsen side effects.

Prevent mosquito bites (such as by using appropriate insect repellents, wearing clothes that cover most of the body, remaining in air-conditioned or well-screened areas, using mosquito nets and insect-killing sprays). Buy insect repellent before traveling. The most effective insect repellents contain diethyltoluamide (DEET). Ask your doctor or pharmacist to recommend the appropriate strengths of mosquito repellent for you/your children.

No drug treatment is completely effective in preventing malaria. Get medical help right away if you develop symptoms of malaria (such as fever, chills, headache, other flu-like symptoms). Malaria can return, even months after completing this prescription. Quick treatment of malaria infection is needed to prevent serious, possibly fatal, outcomes.

When using atovaquone/proguanil for treatment, tell your doctor if your condition lasts or gets worse.

Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction to Malarone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Serious side effect such as:

  • Severe or uncontrolled vomiting or diarrhea
  • Fever, mouth sores
  • Problems with speech, balance, or walking
  • Severe skin rash
  • Nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
  • Easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin

Less serious Malarone side effects may include:

  • Mild stomach pain or upset stomach
  • Mild diarrhea
  • Headache
  • Mild itching
  • Weakness
  • Dizziness

This is not a complete list of side effects and others may occur.


Before taking atovaquone/proguanil, tell your doctor or pharmacist if you are allergic to either atovaquone or proguanil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: current diarrhea, current vomiting, kidney problems, liver problems, mental/mood problems, seizures.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you dizzier. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. While you are pregnant, traveling to an area with malaria places you and your infant at a much higher risk for death and other problems. Discuss the risks and benefits of malaria prevention with your doctor.

It is unknown if atovaquone passes into breast milk. The proguanil in this medication passes into breast milk and the effects of this medication on a nursing infant are not known. The CDC recommends against using this product for malaria prevention if you are breastfeeding an infant weighing less than 11 pounds (5 kilograms). Consult your doctor before breast-feeding.

Form and Strengths

Malarone is available in the following form and strengths:

  • Malarone Tablet:
    • 62.5/25 mg
    • 250/100 mg
  • Atovaquone/Proguanil Tablet:
    • 250/100 mg


What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up for the missed dose.

What happens if I overdose?

Seek emergency medical attention.

Overdose symptoms may include stomach discomfort, vomiting, mouth sores, hair loss, easy bruising or bleeding, and peeling of the skin on your hands or feet.

What should I avoid?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.



Additional information

Brand Name:


Scientific Name:


Other Names:

Atovaquone/proguanil HCL, Malarone, Malarone Pediatric


62.5/25mg, 250/100mg

Quantities Available:

12, 24