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Nix Dermal Cream is a medication that contains the active ingredient permethrin.

Nix Dermal Cream is primarily used to treat scabies, a condition caused by tiny mites that infest and burrow into the skin.

Permethrin works by paralyzing and killing the mites and their eggs.

Use and Dosage

For adults and children 12 years of age and older, the usual amount of cream needed per treatment is approximately one tube (30 g). For children 5 to 12 years of age, the usual amount of cream needed per treatment is ½ of a tube (15 g), and for children 2 to 4 years of age is ¼ of a tube (7.5 g). If the head, neck, scalp, and outer ears require treatment, more cream may be needed to cover these areas. No more than 60 g of cream should be used during an application session.

Before using this product, make sure that your skin is clean, dry, and cool. Do not take a hot bath or shower before using permethrin.

For the lotion form of this medication, shake the bottle before use. For both the lotion and the cream, massage the product into the skin covering the entire area from the neck to the soles of the feet. Pay extra attention to the areas between the fingers and toes, underneath the fingernails and toenails, wrists, armpits, genital area, and buttocks.

Do not apply permethrin to the face. Avoid contact with the eyes, nose, and mouth.

Permethrin will disappear as it is absorbed into the skin, and it is not necessary to coat the skin in a visible layer. If you wash your hands within 8 hours of applying the cream or lotion, reapply the product to the hands. After applying permethrin, put on clean clothes and leave the cream or lotion on for 12 to 14 hours. After this length of time, wash the permethrin off in the bath or shower, and put on a new set of clean clothes.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor or pharmacist has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor or pharmacist.

This medication often gets rid of a scabies infestation after one application. Most people do not need a second application. However, if you see live scabies mites or new lesions on your skin 7 to 10 days after the first application, a second application should be used, in the same manner as the first treatment.

If you are using any other topical medications or cosmetic products, discuss with your doctor or pharmacist whether you should continue to use them while you are using this medication. Most other products should be discontinued when using permethrin.

Since scabies are spread through contact, you should make sure that your family members and sexual partner(s) are examined for scabies infestation. If they are infested, they should speak to their doctor or pharmacist immediately about treatment.

To prevent reinfestation, all clothing, bedding, and towels used by an infected person 2 days before treatment should be machine-washed with hot water and dried in the dryer on the hot cycle for at least 20 minutes, or dry-cleaned. Mattresses used by an infected person should not be used for 48 hours, and toilet seats and combs should be disinfected.

This medication must be used exactly as recommended by your doctor or pharmacist.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe burning, stinging, redness, or swelling after applying permethrin topical.

Common side effects of permethrin topical may include:

  • Mild burning, stinging, itching or mild rash
  • Numbness or tingling where the medicine was applied
  • Headache, dizziness
  • Fever
  • Stomach pain, nausea, vomiting, diarrhea

This is not a complete list of side effects and others may occur.


  • Do not use this medication if you:
    • Are allergic to permethrin or any ingredients of the medication
    • Are allergic to any synthetic pyrethroid or pyrethrins
    • Are allergic to chrysanthemums

Forms and Strengths

Nix Dermal Cream is available in the following forms and strengths:

  • Nix Dermal Cream:
    • 5 %


What happens if I miss a dose?

Since permethrin topical is usually needed only once, you are not likely to be on a dosing schedule. Wait at least 7 days before using a second application.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much, or if anyone has accidentally swallowed the medication.

What should I avoid while using permethrin topical?

Rinse with water if permethrin topical gets in your eyes.

Lice and scabies infections are highly contagious. Avoid sexual or intimate contact with others until your lice or scabies infection has cleared up. Avoid sharing hairbrushes, combs, hair accessories, hats, clothing, bed linens, and other articles of personal use.

Avoid using other medications on the areas you treat with permethrin topical, unless your doctor tells you to.

What other drugs will affect permethrin topical?

It is not likely that other drugs you take orally or inject will affect topically applied permethrin topical. However, many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.



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