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Onglyza (saxagliptin) is a prescription medication used in combination with a proper diet and exercise program to control high blood sugar in adults with type 2 diabetes.

Onglyza works by helping the body increase the level of insulin after meals.

Onglyza should not be used to treat type 1 diabetes or diabetic ketoacidosis.

Use and Dosage

Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start using saxagliptin each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The manufacturer directs not to split/cut the tablet before taking it. However, many similar drugs (immediate-release tablets) can be split/cut. Follow your doctor’s directions on how to take this medication.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended.

Side Effects

Common side effects include:

  • Headache
  • Dizziness
  • Stomach discomfort
  • Runny nose
  • Throat irritation

Mostly, the side effects brought about by this antidiabetic agent are mild and temporary. However, if the adverse reactions worsen or do not resolve over time, you should hold the medication and call your doctor or any healthcare provider.

Severe side effects include:

  • Signs of heart failure (shortness of breath, unusual tiredness, sudden weight gain, swelling of the extremities)
  • Joint pain
  • Unusual skin blisters
  • Hypoglycemia or low blood sugar
  • Hyperglycemia or high blood sugar
  • Signs of pancreatic disease (severe abdominal pain that radiates to the back, persistent nausea, and vomiting)

This is not a complete list of Onglyza’s side effects.


Before taking saxagliptin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, disease of the pancreas (pancreatitis), risk factors for pancreatitis (such as stones in your gallbladder, regular use/abuse of alcohol, high levels of fats/triglycerides in the blood), and heart failure.

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Limit alcohol while taking this medication because it can increase your risk of developing low blood sugar and pancreatitis.

It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.

Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin).

It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Form and Strengths

Onglyza is available in the following form and strengths:

  • Onglyza Tablet:
    • 2.5 mg
    • 5 mg
  • Saxagliptin Tablet:
    • 5 mg


What happens if I miss a dose?

Skip the missed dose and take your next dose at the regular time unless your doctor tells you otherwise. Do not take two doses at one time, and do not take an extra dose the next day.

What happens if I overdose?

Seek emergency medical attention. You may have signs of low blood sugar, such as extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

What to avoid?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.



Additional information

Brand Name:


Scientific Name:


Other Names:

Onglyza, Saxagliptin


2.5mg, 5mg

Quantities Available:

28, 30, 84, 90, 112