Safely Buy Premarin ( Conjugated Estrogen ) from Canada Prescriptions Plus.

We don't sell this generic-version medication.

( Top Brand Option )


Prescription Required
Formulation : Tablet
Drug Name Dosage Quantity Price Buy Now
Premarin 0.3mg 28 $36.10 Add To Cart
Premarin 0.625mg 28 $35.70 Add To Cart
Premarin 0.3mg 56 $56.10 Add To Cart
Premarin 0.625mg 84 $61.10 Add To Cart
Premarin 0.3mg 84 $76.10 Add To Cart
Premarin 0.9mg 100 $710.10 Add To Cart
Premarin 0.45mg 100 $710.10 Add To Cart
Premarin 1.25mg 84 $152.30 Add To Cart
Premarin 1.25mg 168 $289.20 Add To Cart
Dosage: 0.3mg
Quantity: 28
Price: $36.10
Dosage: 0.625mg
Quantity: 28
Price: $35.70
Dosage: 0.3mg
Quantity: 56
Price: $56.10
Dosage: 0.625mg
Quantity: 84
Price: $61.10
Dosage: 0.3mg
Quantity: 84
Price: $76.10
Dosage: 0.9mg
Quantity: 100
Price: $710.10
Dosage: 0.45mg
Quantity: 100
Price: $710.10
Dosage: 1.25mg
Quantity: 84
Price: $152.30
Dosage: 1.25mg
Quantity: 168
Price: $289.20


Premarin is an estrogen medication used to treat symptoms of menopause including hot flashes and vaginal discharge. The medication can also be used to prevent osteoporosis from developing in menopausal women.

This menopause medication combines a mixture of estrogen hormones, conjugated estrogens, which help replace and balance estrogen levels that are missing or decreased during menopause. Thanks to this action, Premarin can help maintain bone health and strength which is at risk when estrogen levels drop during menopause.

Conjugated estrogen has been shown to increase the quality of life for women in menopause by treating and decreasing related symptoms. Most oral hormone therapies add a progesterone with the estrogens, especially for non-hysterectomized women, to reduce the risk of developing endometrial cancer.

Uses and Dosage

The dose of Premarin that is prescribed will vary depending on the individual being treated. Follow your doctor’s instructions and read all medical packaging carefully to ensure the best results during treatment.

  • Swallow tablet whole
  • Take with or without food
  • Premarin may be taken daily or given in a cycle such as 25 days on followed by 5 days off the drug, follow your doctor’s directives
  • Use the lowest dose required for the least amount of time needed for results
  • For vasomotor symptoms, most women start taking 0.3mg daily
  • For vulvar symptoms and vaginal atrophy, most women take 0.3mg
  • For breast cancer treatment, most women take 10mg three times a day for at least 3 months
  • For osteoporosis prevention, most women start with 0.3mg daily
  • Women shouldn’t take more than 0.625mg daily
  • Your doctor should regularly check your progress
  • Self-examine your breasts for lumps monthly and have regular mammograms
  • You may need to suspend this medicine if you need major surgery or will be on long-term bed rest. Tell any doctor or surgeon that you use Premarin
  • Store at room temperature away from moisture, heat, and light
  • Keep out of reach of children and pets

Side Effects

Premarin may cause some side effects to develop while it increases and balances your estrogen levels. Speak with your doctor for more information concerning any symptoms you may encounter when taking conjugated estrogen.

Common Premarin side effects:

  • Swelling
  • Hair loss
  • Numbness, tingling, or burning pain
  • Back pain, leg cramps, body pain
  • Bloating, gas, indigestion, nausea, vomiting, stomach pain
  • Dizziness, headache
  • Breast pain
  • Vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding

Serious Side Effects

Some more serious adverse reactions may occur when taking conjugated estrogen. Stop using Premarin and contact your doctor immediately if you develop any of the following symptoms:

  • Signs of a heart attack (chest pain or pressure, pain spreading to your jaw or shoulder, sweating)
  • Signs of a stroke (sudden numbness or weakness on one side of your body, sudden severe headache, slurred speech, vision or balance problems)
  • Blood clot (sudden vision loss, stabbing chest pain, coughing blood, pain or warmth in one or both legs)
  • Swelling, rapid weight gain
  • Jaundice
  • Memory problems, confusion, unusual behaviour
  • Unusual vaginal bleeding, pelvic pain
  • Lump in your breast
  • High calcium levels in your blood (vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy)

Allergic Reactions

Do not use Premarin if you are allergic to estrogen or any of the tablets’ listed ingredients. If you develop signs of an allergic reaction, stop taking this hormone medication and call your doctor right away.

Premarin allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


Premarin treatment may increase your risk of developing a condition that could lead to uterine cancer, especially if taken by a woman with a uterus without the inclusion of progesterone. Tell your doctor immediately if you have any unusual vaginal bleeding.

Conjugated estrogen may increase your risk for developing blood clots, cancer of the breast, uterus, or ovaries, or of having a stroke or heart attack. Those with high blood pressure, diabetes, high cholesterol, or who are overweight, or smoke may be at a higher risk of developing these issues.

Self-examine your breasts for any lumps monthly and have regular mammograms while taking Premarin.

Avoid smoking while taking Premarin because it can greatly increase your risk of blood clots, stroke, or heart attack, all of which can be deadly.

Avoid ingesting grapefruit and grapefruit juice while taking Premarin because they can interact with conjugated estrogens and cause adverse reactions.

Do not use Premarin if you have any of the following:

  • Unusual vaginal bleeding unchecked by a doctor
  • Liver disease
  • History of heart attack, stroke, or blood clot
  • Increased risk for blood clots due to a heart issue or a hereditary blood disorder
  • History of hormone-related cancer or cancer of the breast, uterus/cervix, or vagina

Do not take conjugated estrogen if you are pregnant. Tell your doctor right away if you become pregnant to determine a safe and effective treatment for you and your child.

To ensure your safety in taking Premarin, tell your doctor if you have ever had any of the following:

  • A hysterectomy
  • Heart disease
  • Liver problems or jaundice caused by pregnancy or taking hormones
  • Kidney disease
  • Gallbladder disease
  • Asthma
  • Epilepsy or another seizure disorder
  • Migraines
  • Lupus
  • Endometriosis or uterine fibroid tumors
  • Hereditary angioedema
  • Porphyria
  • Thyroid disorder
  • High levels of calcium in your blood

Some drugs may interact with conjugated estrogens and cause unwanted side effects. To ensure your safety, tell your doctor about all the medications you take including over the counter medicine, vitamins, and herbal products.

Breastfeeding while taking Premarin may not be safe because estrogen can slow your production of breastmilk. Consult with your doctor if you are breastfeeding.

Form and Strength

This hormone medication is available in tablet form.

Premarin tablet strengths:

  • 0.3mg
  • 0.45mg
  • 0.625mg
  • 0.9mg
  • 1.25mg

The 0.3 and 1.25mg tablets are available in quantities of 84 while the 0.4 and 0.9mg ones are available in groups of 100 and the 0.625mg tablets are available in quantities of 28 or 84.


What time of day should I take Premarin tablets?

You can take your Premarin dose at any time of day without regard for meals. However, you should try to take your dose at the same time each day. Some treatment plans won’t have your take daily doses but will follow a cycle of taking conjugated estrogens for 3 weeks and then stopping for 1 week and repeating.

What to avoid when taking Premarin?

You should avoid eating or drinking any grapefruit products while taking Premarin. This is because grapefruit can interact with conjugated estrogens and lead to adverse reactions. You also shouldn’t smoke during treatment because it can greatly increase your risk of blood clots, stroke, or heart attack.



Additional information

Brand Name:


Scientific Name:

Conjugated Estrogen

Other Names:



0.3mg, 0.9mg, 0.45mg, 0.625mg, 1.25mg

Quantities Available:

28, 56, 84, 100, 168