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Prilosec is a proton pump inhibitor used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions related to excess stomach acid. This medication may also be used to promote the healing of damage in the esophagus caused by stomach acid.

Omeprazole belongs to the benzimidazole class of proton pump inhibitors (PPIs) and helps reduce the amount of stomach acid your body produces. The medication does this by blocking an enzyme that controls acid production.

Prilosec reduces stomach acid to help treat and prevent frequent heartburn and symptoms of conditions caused by excess stomach acid.

Uses and Dosage

The dosage of Prilosec prescribed will vary depending on the individual and condition being treated. Follow your doctor’s instructions and read the medicine’s packaging carefully.

  • Take Prilosec before eating in the morning
  • Swallow capsule whole
  • Take with a full glass of water
  • Do not take more than one capsule a day
  • Do not use for more than 14 days
  • Your symptoms may take 1 to 4 days to improve
  • Wait 4 months before starting another course of treatment

Side Effects

Prilosec may cause some side effects while reducing the quantity of stomach acid you produce. Consult with your doctor for more information or advice concerning symptoms you may encounter when taking omeprazole.

Common Prilosec side effects:

  • Cold symptoms (stuffy nose, sneezing, sore throat)
  • Fever
  • Stomach pain, gas
  • Nausea, vomiting, diarrhea
  • Headache

Cold symptoms including fevers may be more likely to occur in children taking Prilosec.

Serious Side Effects

Some more serious side effects may occur when taking Prilosec. Stop taking this acid reducer and call your doctor right away if you notice any of the following symptoms:

  • Severe stomach pain
  • Watery or bloody diarrhea
  • New or unusual pain in your wrist, thigh, hip, or back
  • Seizure
  • Kidney problems (fever, rash, nausea, decreased appetite, joint pain, urinating less frequently, blood in your urine, weight gain)
  • Low magnesium (dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling)
  • New or worsening symptoms of lupus (joint pain, skin rash on cheeks or arms that worsens under in the sun)

When taken long-term, Prilosec may cause stomach growths called fundic gland polyps to develop.

Allergic Reactions

Do not take Prilosec if you are allergic to omeprazole or similar medications such as esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, and more. Stop taking this acid reducer and call your doctor if you notice any signs of an allergic reaction.

Prilosec allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


Prilosec is not designed to provide immediate relief from heartburn symptoms. This medication may take 1 to 4 days for full effect.

This medication may cause diarrhea which can signal a new infection. Call your doctor before using anti-diarrhea medication if your diarrhea is watery or bloody.

Heartburn may be confused with early symptoms of a heart attack. Seek immediate medical attention if you experience chest pain or heavy feeling, pain spreading from the arm or shoulder, nausea, sweating, and a general ill feeling.

Do not take Prilosec if you have any of the following:

  • Breathing problems
  • Kidney problems
  • Severe allergic reaction from omeprazole in the past

Do not use this medication if you also take HIV medication that contains rilpivirine, such as Complera, Edurant, or Odefsey.

Consult with your doctor to ensure the safety of taking Prilosec; let them know if you have any of the following:

  • Trouble or pain with swallowing
  • Bloody or black stools
  • Vomit with blood or that looks like coffee grounds
  • Heartburn that has lasted longer than 3 months
  • Frequent chest pain, heartburn with wheezing
  • Unexplained weight loss
  • Nausea or vomiting, stomach pain
  • Liver disease
  • Low magnesium levels in your blood
  • Osteoporosis or low bone mineral density

Omeprazole may lead to kidney problems. Let your doctor know if you are urinating less frequently or if you have blood in your urine.

Taking Prilosec may lead to new or worsening symptoms of lupus. Tell your doctor if you notice or develop joint pain with a skin rash on your cheeks or arms that worsens under sunlight.

When taking this medication long term or more than once a day, your risk for breaking bones may increase.

Some other medications can interact with Prilosec and cause unwanted side effects or a decrease in effectiveness. Tell your doctor about all the medications you take, especially the following:

  • Digoxin
  • Clopidogrel
  • Methotrexate
  • St. John’s wort
  • A diuretic
  • An antibiotic

Other types of medications may also interact with omeprazole, including over the counter medicine, vitamins, and herbal products.

Allow at least four months to pass before taking a 14-day treatment of Prilosec. Avoid taking this medication for longer than 14 consecutive days.

Consult with your doctor before using Prilosec when pregnant or breastfeeding.

Do not give Prilosec to children without advice from your doctor.

Form and Strength

This medication is available in capsule form.

  • Prilosec capsule strengths:

    • 10mg
    • 20mg
    • 40mg

The 10mg and 40mg capsules are available in quantities of 84 and 90 while the 20mg capsules are available in groups of 28, 84, and 90.


Can I take omeprazole in the morning and famotidine at night?

You can take famotidine at night without decreasing the effectiveness of a morning dose of omeprazole. Some research suggests taking these medications together can provide better control of acid secretion during the night, but more information is needed.

What foods should I avoid when taking omeprazole?

You don’t need to avoid specific food or drinks to prevent side effects or other issues when taking omeprazole. To help prevent and relieve symptoms related to excess acid, indigestion, heartburn, or stomach ulcers, you may want to avoid some foods that cause aggravation. These can include acidic, fatty, or greasy foods, white wine, and beer.



Additional information

Brand Name:


Scientific Name:


Other Names:

Losec, Omeprazole, Omez


10mg, 20mg, 40mg

Quantities Available:

28, 84, 90


Capsule, capsule