Safely Buy Roszet ( Ezetimibe/rosuvastatin ) from Canada Prescriptions Plus.

Indications

Roszet is a combination medication that contains two active ingredients: rosuvastatin and ezetimibe. This combination medication is used along with a proper diet to help lower “bad” cholesterol (such as LDL).

Ezetimibe works by reducing the amount of cholesterol your body absorbs from your diet. Rosuvastatin belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver.

Use and Dosage

Read the Patient Information Leaflet if available from your pharmacist before you start taking this product and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily. Swallow the tablets whole. Do not crush, chew, or dissolve tablets.

The dosage is based on your medical condition, response to treatment, race, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). If you are of Asian descent, your doctor may direct you to start with a lower dose because you may be more sensitive to its effects.

If you are taking a bile acid sequestrant (such as cholestyramine or colestipol), take this product at least 2 hours before or at least 4 hours after taking the bile acid sequestrant. These medications may bind to ezetimibe/rosuvastatin, preventing your body from fully absorbing the drug.

Antacids containing aluminum and magnesium can reduce the absorption of this drug. If taking this type of antacid, take it at least 2 hours after this medication.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking this medication even if you feel well. Most people with high cholesterol do not feel sick.

Side Effects

Roszet may cause serious side effects, including:

• Swelling of the face, lips, tongue, and/or throat which makes it difficult to swallow or breathe
• Breathing problems or wheezing
• Feeling dizzy or fainting
• Rash or hives
• Itching

Muscle pain, tenderness, and weakness (myopathy). Muscle problems, including muscle breakdown, can be serious in some people and rarely causes kidney damage that can lead to death. You have a higher chance of muscle problems if you are taking certain other medicines with Roszet. Tell your healthcare provider right away if:

• You have unexplained muscle pain, tenderness, or weakness, especially if you have a fever or feel more tired than usual, while you take Roszet.
• You have muscle problems that do not go away even after your healthcare provider has advised you to stop taking Roszet. Your healthcare provider may do further tests to diagnose the cause of your muscle problems.

Your chances of getting muscle problems are higher if you:

• Are taking certain other medicines while you take Roszet
• Are 65 years of age or older
• Are of Asian descent
• Have thyroid problems (hypothyroidism) that are not controlled
• Have kidney problems
• Are taking higher doses of Roszet
• Have liver problems

Your healthcare provider may do blood tests to check your liver before you start treatment and if you have symptoms of liver problems while you take Roszet. Call your healthcare provider right away if you have the following symptoms of liver problems:

• Feel tired or weak
• Upper belly pain
• Yellowing of your skin or the whites of your eyes
• Loss of appetite
• Dark urine

The most common side effects include:

• Headache
• Weakness
• Diarrhea
• Dizziness
• Pain (back, hands, legs)
• Nausea
• Constipation
• Joint pain
• Stomach pain
• Muscle aches and pains
• Common cold and flu
• Runny nose and sore throat
• Tiredness

Tell your healthcare provider if you have any side effects that bother you or that do not go away.

These are not all the possible side effects.

Cautions

• Before taking this product, tell your doctor or pharmacist if you are allergic to ezetimibe or rosuvastatin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
• Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, and alcohol use.
• Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
• Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with this product. Ask your doctor or pharmacist for more information.
• Older adults may be more sensitive to the side effects of this drug, especially muscle problems.
• During pregnancy, this medication should be used only when needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor.
• It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breastfeeding while using this product is not recommended. Consult your doctor before breast-feeding.

Forms and Strengths

Roszet is available in the following forms and strengths:

• Roszet Table:
  • 5/10mg, 10/10mg, 20/10mg

FAQ

What happens if I miss a dose?

Use the medicine as soon as you can but skip the missed dose if your next dose is due in less than 12 hours. Do not use two doses within 12 hours.

What happens if I overdose?

Seek emergency medical attention.

What should I avoid while taking ezetimibe and rosuvastatin?

Avoid taking an antacid within 2 hours after you take ezetimibe and rosuvastatin.

Grapefruit may interact with ezetimibe and rosuvastatin and lead to unwanted side effects. Avoid the use of grapefruit products.

Avoid drinking alcohol.

Avoid eating foods high in fat or cholesterol, or ezetimibe and rosuvastatin will not be as effective.

Resources:

1. https://www.drugs.com/roszet.html#side-effects
2. https://www.webmd.com/drugs/2/drug-181226/roszet-oral/details
3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/213072s000lbl.pdf