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Seroquel is an antipsychotic medication used to treat and manage symptoms of schizophrenia, bipolar disorder, and major depressive disorder (MDD).

Quetiapine is an atypical antipsychotic derived from dibenzothiazepine that antagonizes receptors in your brain to help balance chemicals. Seroquel’s antagonistic actions also provide anxiolytic and antidepressant properties which help manage symptoms of bipolar disorder and depression as well as schizophrenia.

This antipsychotic medication is generally well-tolerated and effectively counteracts both positive and negative schizophrenia symptoms. Seroquel has been found beneficial for those whose conditions have been unresponsive to other antipsychotic treatments.

Uses and Dosage

The dose of Seroquel prescribed will vary depending on the individual and condition being treated. Follow your doctor’s directions and read all label packaging carefully.

  • Take with or without food
  • Swallow tablet whole
  • Take with a full glass of water
  • Most take an initial dose that is increased by 25 or 50mg
  • For Schizophrenia, most adults take 150 to 750mg daily
  • For bipolar disorder, most adults take 400 to 800mg a day
  • Do not double dose
  • Do not suddenly stop using Seroquel
  • Seroquel may cause high blood sugar
  • Drug screening tests may read false positive due to quetiapine
  • Store at room temperature away from moisture

Side Effects

Seroquel may cause some side effects while it affects your brain chemicals. Speak with your doctor for more information and advice regarding any symptoms you may encounter.

Common Seroquel side effects:

  • Speech issues
  • Dizziness, drowsiness, tiredness
  • Lack of energy
  • Fast heartbeats
  • Stuffy nose
  • Increased appetite, weight gain
  • Upset stomach, vomiting, constipation
  • Dry mouth
  • Problems moving

Serious Side Effects

Some more serious side effects may occur when taking Seroquel. Stop taking this antipsychotic medication and contact your doctor as soon as you notice any of the following symptoms:

  • Uncontrolled muscle movements in face
  • Mask-like appearance, trouble swallowing, speech problems
  • Light-headed feeling like you might pass out
  • Blurred or tunnel vision, eye pain, seeing halos around lights
  • Severe nervous system reaction (rigid muscles, high fever, sweating, confusion, fast or uneven heart rate, tremors, fainting)
  • High blood sugar (increased thirst and urination, hunger, dry mouth, druity breath odour, drowsiness, dry skin, blurred vision, weight loss)
  • Low blood cell count (sudden weakness or ill feeling, chills, fever, flu symptoms, cough, sore throat, red or swollen gums, painful mouth sores, skin sores, trouble breathing)

Report new or worsening symptoms to your doctor as soon as you can, especially the following:

  • Changes in mood or behaviour
  • Anxiety, panic attacks
  • Trouble sleeping
  • Feeling impulsive, agitated, hostile, aggressive, hyperactive
  • Worsening depression
  • Suicidal thoughts or actions

Allergic Reactions

Do not take Seroquel if you are allergic to quetiapine. If you notice signs of an allergic reaction, stop taking this medication and call your doctor.

Seroquel allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling in face, lips, tongue, or throat


Avoid drinking alcohol when taking Seroquel; it can interact with quetiapine and lead to dangerous side effects.

Seroquel can impair your thoughts and reactions. Avoid driving or performing any tasks requiring you to be alert until you know how this medication will affect you.

Do not take more than your prescribed dose or for longer than prescribed to avoid developing a serious movement disorder. Monitor your symptoms and contact your doctor right away if you experience tremors or other uncontrollable muscle movements.

Stop using Seroquel immediately and call your doctor if you develop any of the following symptoms:

  • Stiff muscles
  • High fever, sweating, confusion
  • Fast or uneven heartbeats
  • Tremors, uncontrolled muscle movements
  • Feeling light-headed
  • Blurred vision, eye pain
  • Increased thirst and urination
  • Excessive hunger
  • Fruity breath odour
  • Weakness
  • Nausea, vomiting

When used alongside certain medications, Seroquel can cause serious heart problems. Tell your doctor about every medication you take, including over the counter, vitamins, and herbal products, but especially the following:

  • Antibiotic or antifungal medications
  • Antiviral medicine for hepatitis, HIV, or AIDS
  • Heart or blood pressure medicine
  • Medication for mental illness
  • St. John’s wort
  • Seizure medication
  • Medicines for tuberculosis

Avoid using drugs that make you sleepy or slow you breathing while taking Seroquel to prevent dangerous side effects. Consult with your doctor before using a sleeping pill, narcotic pain medicine, prescription cough medicine, muscle relaxants, or medicine for anxiety, depression, or seizures.

Some young people may have suicidal thoughts when first taking Seroquel. Monitor changes in your mood or symptoms and report them to your doctor.

Quetiapine is not an approved treatment for psychotic conditions related to dementia and may increase the risk of death in older adults who have these conditions.

To ensure this medication is safe for you to take, tell your doctor if you have or have ever had any of the following:

  • Liver or kidney disease
  • Heart disease, heart rhythm issues, history of heart attack or stroke
  • High or low blood pressure
  • History of low white blood cell count
  • Abnormal thyroid tests or prolactin levels
  • Seizures or epilepsy
  • Cataracts
  • High cholesterol or triglycerides
  • Personal or family history of diabetes
  • Difficulty swallowing

Consult with your doctor if you become pregnant while taking Seroquel. Antipsychotic drugs like quetiapine can cause complications in a newborn when used during the last three months of pregnancy. These problems can include withdrawal symptoms, breathing issues, feeding problems, fussiness, tremors, and limp or stiff muscles. Do not stop taking Seroquel without talking to your doctor.

Do not breastfeed while taking Seroquel unless directed to do so by your doctor.

Seroquel may affect female fertility while being taken.

Quetiapine should not be given to anyone younger than 18 years old without a doctor’s advice.

Avoid becoming overheated or dehydrated while taking Seroquel, you may have a higher risk of developing heat stroke.

Avoid eating grapefruit or drinking grapefruit juice because it can cause an increase in quetiapine side effects.

Form and Strength

This antipsychotic medication is available in tablet form.

Seroquel tablet strengths:

  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 300mg

All tablet strengths are available in quantities of 90 or 100 while the 200mg tablets are also available in groups of 50.


When will Seroquel start working?

Seroquel needs to work into your system and inhibit receptors in your brain; this will take some time before you experience its full effects. When you first start taking this antipsychotic medication, you also need to work up to an effective dose which can take some time. After several days or a few weeks, your symptoms should improve.

Can quetiapine cause diabetes or make diabetes worse?

A side effect of Seroquel is an increase in blood sugar levels, but this affects less than 1 in 100 people and is unlikely. Your doctor should run blood tests to check how much sugar you have and will monitor if there are any changes after you start taking Seroquel.

Is there any food or drink I need to avoid while taking Seroquel?

Do not eat grapefruit or drink its juice when taking Seroquel because it can cause side effects to increase. You should also avoid drinking alcohol because it can interact with quetiapine and cause adverse side effects. Other than this, you can eat and drink as normal.



Additional information

Brand Name:


Scientific Name:

Quetiapine, Quetiapine Fumarate

Other Names:

Quetiapine, Qutan, Qutipin, Seroquel


25mg, 50mg, 100mg, 200mg, 300mg

Quantities Available:

30, 50, 90, 100