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Sinemet is a dopaminergic medication used to treat symptoms of Parkinson’s disease (PD).

The medication uses a combination of carbidopa and levodopa to increase dopamine levels in your brain to reduce symptoms including muscle stiffness, tremors, spasms, and poor muscle control. Thanks to this ability, Sinemet can improve the quality of life for Parkinson’s patients and reduce ‘off-time’ periods.

This anti-parkinsonism medication is an effective treatment for PD symptoms. Sinemet is well-tolerated and has a lower incidence of adverse effects such as dyskinesia, especially for patients with early PD.

Uses and Dosage

The dose of Sinemet that is prescribed will vary depending on the individual and the severity of their condition being treated. Follow all your doctor’s directives and read packaging instructions carefully to ensure the best results.

  • Swallow tablet whole, do not crush or chew
  • Take with or without food at regular intervals
  • Adults should take a maintenance dose of at least 70 to 100mg of carbidopa daily
  • Adults usually take 8 Sinement 25-100 tablets a day
  • Most adults begin with one tablet 3 times a day and then increase by one tablet
  • If using Sinemet 10-100, most take 2 tablets 4times a day
  • The 10-100 tablets should be initiated by taking one tablet 3 or 4 times a day before increasing
  • If you already take levodopa, stop taking it at least 12 hours before starting Sinemet treatment
  • Your symptoms may take several weeks to fully improve, continue using as directed
  • Tell your doctor if symptoms don’t improve or if the medication wears off quickly
  • Tell any doctor that treats you that you use Sinemet because it can affect tests
  • Store at room temperature away from moisture, heat, and light
  • Keep out of reach from children and pets

Side Effects

Sinemet may cause some side effects to develop while increasing the dopamine levels in your brain. Speak with your doctor for more information regarding any symptoms you may experience when taking carbidopa and levodopa.

Common Sinemet side effects:

  • Jerky or twisting muscle movements
  • Headache, dizziness
  • Low blood pressure
  • Sleep problems, strange dreams
  • Dry mouth
  • Muscle contractions
  • Nausea, vomiting, constipation

You may have an increase in sexual urges, the urge to gamble, or other intense urges during treatment with Sinemet. Tell your doctor if you experience any sudden, new urges.

When taking Sinemet, you may notice that your sweat, urine, or saliva is darker in colour such as red, brown, or black. This is not harmful, but it may stain your clothes or bed sheets.

Serious Side Effects

Some more serious adverse events may occur when taking a combination of carbidopa and levodopa. Stop using Sinemet and contact your doctor right away if you develop any of the following effects:

  • Uncontrolled facial muscle movements (chewing, lip smacking, frowning, tongue movement, blinking or eye movement)
  • Worsening tremors
  • Severe or ongoing vomiting or diarrhea
  • Confusion, hallucinations, unusual changes in mood or behaviour
  • Depression or suicidal thoughts
  • Severe nervous system reaction (rigid muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out)

Some Sinemet users have reported falling asleep during daytime activities such as working, talking, eating, or driving. Contact your doctor if you have any issues with sleepiness or drowsiness during the day.

Allergic Reactions

Do not use Sinemet if you are allergic to carbidopa or levodopa. If you develop an allergic reaction, stop taking this anti-parkinsonism medication and call your doctor.

Sinemet allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


Do not take Sinemet if you have narrow-angle glaucoma.

If you have taken an MAO inhibitor within the last 14 days, wait to use Sinemet to avoid a dangerous drug interaction. These inhibitors include isocarboxazid, linezolid, methylene blue injection, and others.

To ensure your safety in taking Sinemet, tell your doctor if you have any of the following:

  • Heart disease, high blood pressure, heart attack
  • Liver or kidney disease
  • Endocrine disorder
  • Asthma, chronic obstructive pulmonary disease, or another breathing disorder
  • Stomach or intestinal ulcer
  • Open-angle glaucoma
  • Depression, mental illness, or psychosis

People who have Parkinson’s disease may be at a higher risk for developing skin cancer. Speak with your doctor to determine your risk levels and learn about symptoms to monitor for.

Consult with your doctor before using Sinemet if you are pregnant or breastfeeding.

Some other drugs may interact with carbidopa or levodopa and cause unwanted side effects. Tell your doctor about all the medications you take to avoid this, including over the counter medicine, vitamins, and herbal products.

Form and Strength

This anti-parkinsonism medication is available in regular release tablets.

Sinemet regular release tablet strengths:

  • 10mg carbidopa / 100mg levodopa
  • 25/100mg
  • 25/250mg

The Sinemet tablets are all available in quantities of 100 while the 25/250mg strength tablets are also available in quantities of 200.


How long does it take Sinemet to work?

The Sinemet tablets are quickly absorbed into your system and should begin taking effect within an hour of taking your dose. This offers fast relief from motor symptoms. When taken throughout the day, Sinemet helps improve quality of life by reducing and managing symptoms of PD.

How often should Sinemet be taken?

Your Sinemet dosage regimen will depend on your body’s absorption and tolerability as well as the severity of your Parkinson’s disease. Most patients take their dose 3 or 4 times each day to maintain their treatment of PD.



Additional information

Brand Name:


Scientific Name:


Other Names:

Sinemet, Sinemet Plus, Syndopa


10/100mg, 25/100mg, 25/250mg

Quantities Available:

100, 200


Regular Release Tablet, Scored Tablet, Tablet