Safely Buy Xadago ( Safinamide Methansulfonate ) from Canada Prescriptions Plus.

Indications

Xadago is dopaminergic medicine used to treat episodes of muscle stiffness and loss of muscle control in those with Parkinson’s disease when combined with levodopa and carbidopa.

Safinamide methansulfonate is a monoamine oxidase type B (MAO-B) inhibitor that increases your levels of dopamine and dopaminergic brain activity. Low dopamine levels are associated with Parkinson’s disease and contributes to muscular symptoms of the condition. Increasing dopamine allows Xadago to treat symptoms of “off” episodes of Parkinson’s when used in combination with levodopa and carbidopa.

Dosage and Administration

The dose of Xadago that is prescribed will vary depending on the individual being treated. Follow all your healthcare provider’s instructions carefully and read packaging labels carefully for the best results during treatment. Do not change your dose or take this medication more or less often than prescribed on your own.

• Swallow tablet whole
• Take at the same time each day with or without food
• Most adults start treatment by taking 50mg once daily
• After 2 weeks of treatment, doses can increase to 100mg once a day if needed and tolerated
• Do not take more than 100mg daily
• Before stopping treatment with Xadago, your dose should taper to 50mg for one week
• Store at room temperature away from children and pets

Side Effects

Xadago may cause you to develop some side effects while increasing your levels of dopamine. Speak with your healthcare provider to learn more about any symptoms you may experience during treatment.

Common Xadago side effects:

• Involuntary muscle movements
• Falls
• Nausea
• Insomnia

Xadago may cause you to have increased sexual urges as well as unusual urges to gamble, eat, or shop during treatment. Speak with your healthcare provider if you notice any sudden, unusual urges.

Serious Side Effects

Some more serious adverse effects may occur when taking Xadago. Contact your healthcare provider right away if you develop any of the following symptoms:

• Changes in vision
• Twitching or uncontrollable muscle movements
• Confusion, agitation, unusual thoughts or behaviours
• Hallucinations
• Seizures
• Fever, sweating, fast heartbeat, overactive reflexes
• Nausea, vomiting, diarrhea
• High blood pressure (severe headache, blurred vision, pounding in your ears or neck, anxiety, nosebleeds)

Allergic Reactions

Do not take Xadago if you are allergic to safinamide methansulfonate or any of the other tablet ingredients. Call your healthcare provider immediately if you notice any of the following signs of an allergic reaction:

• Hives
• Trouble breathing
• Swelling of your face, lips, tongue, or throat

Cautions

• Do not use Xadago if you have severe liver disease.
• To ensure your safety when taking Xadago, tell your healthcare provider if you have ever had any of the following:
  • Liver disease
  • High or low blood pressure
  • Bipolar disorder, schizophrenia, or psychosis
  • Unusual urges or impulses
  • Abnormal muscle movements
  • Problems with your retinas
  • Narcolepsy or another sleeping disorder
• Some drugs can interact with Xadago and cause dangerous effects. Do not use any of the following medications for 14 days before or after using Xadago to avoid reactions:
  • Amphetamine drugs
  • Cough medicine containing dextromethorphan
  • Cyclobenzaprine
  • Methylphenidate
  • St. John’s wort
  • Another MAO inhibitor (isocarboxazid, linezolid, methylene blue injection, and more)
  • Certain antidepressant medicines (amitriptyline, desipramine, desvenlafaxine, and others)
  • Opioid medications (meperidine, methadone, propoxyphene, and others)
• Tell your healthcare provider about all the medications you use to avoid unwanted reactions, including over the counter medicines, but especially any of the following:
  • Imatinib
  • Irinotecan
  • Lapatinib
  • Methotrexate
  • Metoclopramide
  • Mitoxantrone
  • Rosuvastatin
  • Sulfasalazine
  • Topotecan
• Tell your healthcare provider if you are pregnant or plan to become pregnant before taking Xadago. This medication may or may not cause harm to your unborn baby.
• Ask your healthcare provider about the risks of breastfeeding during treatment before taking Xadago. It is unclear if this medication passes into breast milk and whether it could affect your nursing child.
• Avoid eating foods that are high in tyramine during treatment with Xadago and for 14 days after your last dose. These foods include pickled foods such as eggs or herring as well as meats that are cured, aged, smoked, or fermented. Tyramine can raise your blood pressure to dangerous levels when eaten during treatment with Xadago.
• Xadago may cause you to become drowsy or fall asleep during normal day time activities, even if you previously felt alert. Avoid driving or operating any hazardous machines until you know how this medication will affect you and your reactions.

Form and Strength

This Parkinson’s medication is available in tablet form.

• Xadago tablet strength:
  • 100mg

The 100mg Xadago tablets are available in quantities of 90.

FAQ

How do I take Xadago?

It is recommended that you start treatment with Xadago by taking 50mg once a day. After 2 weeks, your dose can increase to 100mg once daily if needed and tolerated. Ensure that you take your daily dose at the same time each day. Xadago should also be taken alongside levodopa and carbidopa as prescribed.

Do I have to change my diet with Xadago?

During treatment with Xadago, your doctor may recommend that you avoid eating any foods that are high in tyramine because this can cause your blood pressure to raise to dangerously high levels when taken with this medicine. Some tyramine-containing foods include pickled foods such as pickled eggs or herring as well as meats that are cured, smoked, aged, or fermented. Follow all directions provided by your healthcare provider for the best results during treatment.

Resources:

1. https://www.drugs.com/xadago.html
2. https://www.xadago.com/
3. https://www.xadago.com/XADAGO_PatientPI.pdf
4. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=c4d65f28-983f-42b4-bb23-023ae0fe81b2&type=display#section-11.1