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Dosage: 8mg
Quantity: 10
Price: $48.30
Dosage: 8mg
Quantity: 60
Price: $217.20


Zofran is a medication used to prevent nausea and vomiting that could be caused by surgery, chemotherapy, or radiation treatment.

Ondansetron is a serotonin receptor antagonist antiemetic that blocks gastrointestinal vagal nerves and inhibits trigger zones for chemoreceptors. This allows Zofran to reduce nausea and instances of vomiting relating to cancer chemotherapy.

This emetic medication is well-tolerated with few adverse effects and is quickly absorbed into your gastrointestinal tract. Zofran reaches its peak concentration within 2 hours to help prevent nausea after receiving cancer treatment.

Uses and Dosage

The dose of Zofran prescribed will depend on the individual being treated. Always follow your doctor’s advice and read packaging labels carefully.

  • Take with or without food
  • May see benefit from taking after a meal
  • Swallow tablet whole
  • Take 30 minutes before chemotherapy
  • Take 4 and 8 hours after receiving treatment
  • For highly emetogenic chemotherapy, most take 24mg before treatment
  • For moderate emetogenic chemotherapy, most take 8mg
  • For radiotherapy, most take 8mg one to two hours before each treatment
  • Store at room temperature away from heat

Side Effects

Zofran may cause some side effects to develop while it blocks triggers for nausea. Speak with your doctor for more information regarding any symptoms you may encounter when taking ondansetron.

Common Zofran side effects:

  • Diarrhea or constipation
  • Headache
  • Drowsiness
  • tiredness

Serious Side Effects

Some more serious side effects may occur when taking Zofran. Stop using this emetic medication and call your doctor right away if you notice any of the following symptoms:

  • Severe constipation, stomach pain, bloating
  • Headache with chest pain and severe dizziness
  • Fainting, fast or pounding heartbeats
  • Fast or pounding heartbeats
  • Jaundice
  • Blurred vision or temporary vision loss
  • High serotonin levels (agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting)

Allergic Reactions

Do not take Zofran if you are allergic to ondansetron or similar drugs such as dolasetron, granisetron, or palonosetron. If you notice signs of an allergic reaction stop using this medication and contact your doctor.

Zofran allergy symptoms may include:

  • Rash
  • Hives
  • Fever
  • Chills
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


Do not use Zofran if you are also using apomorphine to avoid adverse reactions from a drug interaction.

Zofran may impair your thoughts or reactions; be careful when driving or performing any activity that requires you to be alert.

To ensure the safety of taking ondansetron, tell your doctor if you have any of the following:

  • Liver disease
  • Electrolyte imbalance
  • Congestive heart failure, slow heartbeats
  • Personal or familial history of long QT syndrome
  • Blockage in your digestive tract

Zofran may cause a serious heart problem, especially if used at the same time as certain medications such as antibiotics, antidepressants, heart rhythm medicine, antipsychotic medications, and medicine used to treat cancer, malaria, HIV, or AIDS. Tell your doctor about all the medications you take, including over the counter medicine, vitamins, and herbal products.

When used with certain medications, Zofran can cause an increase in serotonin levels and may lead to the development of serotonin syndrome. Tell your doctor if you use any of the following:

  • Medication for depression
  • Medicine to treat a psychiatric disorder
  • Opioid medication
  • Other medications to prevent nausea and vomiting

Ondansetron is not expected to cause harm to an unborn baby; tell your doctor if you become pregnant. Consult with your doctor before breastfeeding while taking Zofran, it is not known if ondansetron passes into breast milk or if it could harm a nursing child.

Zofran is not an approved treatment for anyone under the age of 4.

Form and Strength

This nausea medication is available in tablet form.

Zofran tablet strengths:

  • 4mg
  • 8mg

The 4mg tablets are available in quantities of 100 while the 8mg ones are available in quantities of 10 or 60.


When should you take ondansetron?

You should take Zofran as prescribed by your doctor. If using for nausea caused by meals, take a dose half an hour to an hour before meals. If you are using this medication for nausea that lasts all day, take it at regular intervals as outlined by your doctor. This medication should also be used before and after chemotherapy treatment to prevent nausea and vomiting.

How long does Zofran take to work?

Ondansetron is easily absorbed by your body and starts working within half an hour. The medication may take up to two hours to offer its full effects, depending on your metabolism.

Does Zofran make you sleepy?

Yes, one of the possible side effects of Zofran is tiredness or drowsiness. Your doctor will outline a treatment plan for when to take your doses. Be careful when driving or performing tasks that require alertness.



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Quantities Available:

10, 60