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Zyprexa is an antipsychotic medication used to treat mental conditions such as schizophrenia and bipolar disorder.

Olanzapine is an atypical antipsychotic drug that helps balance and maintain levels of chemicals in your brain including dopamine and serotonin. This action helps relieve the effects of schizophrenia and bipolar disorder.

This medication is well-tolerated and can be used as treatment for adults and children over 13 years old with schizophrenia or bipolar disorder.

Uses and Dosage

The dose of Zyprexa prescribed will vary depending on the individual and condition being treated. Always follow your doctor’s directions and read packaging labels carefully.

  • Take with or without food
  • Adults usually take an initial dose of 5 to 10mg once daily
  • For schizophrenia, adults should take 10 to 15mg daily
  • For bipolar disorder, adults usually start with 10 to 15mg daily
  • Do not take more than 20mg daily
  • Adolescents start with 2.5 to 5mg before moving to 10mg daily
  • Do not suddenly stop taking Zyprexa

Side Effects

Zyprexa may cause some side effects to occur while it affects the chemicals in your brain. Speak with your doctor for more information regarding any symptoms you may encounter when taking olanzapine.

Common Zyprexa side effects:

  • Weight gain, increased appetite
  • Headache, dizziness, drowsiness, feeling tired or restless
  • Speech or memory problems
  • Tremors or shaking, numbness or tingling
  • Changes in personality
  • Dry mouth, or increased salivation
  • Stomach pain, constipation
  • Pain in your arms or legs

Serious Side Effects

Some more serious side effects may develop when taking Zyprexa. Stop using this antipsychotic medication and contact your doctor if you notice any of the following symptoms:

  • Uncontrolled face muscle movements
  • Trouble speaking or swallowing
  • Swelling in hands and feet
  • Confusion, unusual thoughts or behaviours, hallucinations, suicidal thoughts
  • Low white blood cell counts (fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing, light-headedness)
  • Signs of dehydration (feeling thirsty or hot, unable to urinate, heavy sweating, hot and dry skin)
  • Liver problems (upper stomach pain, itching, loss of appetite, dark urine, clay-coloured stools, jaundice)
  • High blood sugar (increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss)
  • Severe nervous system reaction (stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out)

Seek immediate medical attention if you develop a serious drug reaction. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or jaundice.

Allergic Reaction

Do not use Zyprexa if you are allergic to olanzapine. If you notice signs of an allergic reaction, stop taking this medication and call your doctor right away.

Zyprexa allergy symptoms may include:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


Zyprexa may impair your thinking or reactions; so be careful when driving or performing any tasks that require alertness.

Avoid drinking alcohol while taking Zyprexa because it can cause adverse effects.

Zyprexa may cause you to gain weight or have high cholesterol and triglycerides, especially when used by teenagers.

Olanzapine can cause an increase in blood sugar levels. You should check your blood sugar often when taking Zyprexa if you are diabetic.

You may become overheated or dehydrated more easily when taking Zyprexa which can reach dangerous levels. Drink plenty of fluids while taking this medication.

To ensure the safety of taking Zyprexa, tell your doctor if you have ever had any of the following:

  • Liver disease
  • Heart disease
  • High or low blood pressure
  • High cholesterol or triglycerides
  • Stroke, including “mini stroke”
  • Breast cancer
  • Seizure
  • Alzheimer’s disease
  • Diabetes or high blood sugar
  • Enlarged prostate
  • Bowel problems
  • Narrow-angle glaucoma

High doses of olanzapine may lead to a serious movement disorder. Using high doses for long periods of time can increase the likelihood of developing this disorder, especially if you are a woman or an older adult.

If used alongside other drugs that cause drowsiness or slow your breathing, Zyprexa’s effects could be heightened and cause dangerous or life-threatening reactions. Consult with your doctor before using an opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Some medications may interact with olanzapine and cause adverse reactions. Tell your doctor about all the medications you take, including over the counter medicine, vitamins, and herbal products.

Do not use antipsychotic medicine, including Zyprexa, during the last 3 months of pregnancy to help avoid problems in your newborn such as breathing, feeding, and withdrawal issues. Tell your doctor as soon as you become pregnant. Do not stop taking olanzapine without your doctor’s advice.

Olanzapine can pass into breast milk. Tell your doctor if you notice severe drowsiness, irritability, feeding problems, tremors, or unusual muscle movements in the nursing baby if you use Zyprexa while breastfeeding.

Form and Strength

This antipsychotic medication is available in tablet form.

Zyprexa tablet strengths:

  • 2.5mg
  • 5mg
  • 7.5mg
  • 10mg
  • 15mg
  • 20mg

The 2.5 and 5mg tablets are available in quantities of 28, 84, and 100 while the 10 and 20mg tablets are available in quantities of 84 and the 7.5mg ones are available in groups of 84 and 100.


Will Zyprexa cause me to gain weight?

A common side effect of olanzapine is an increase in appetite and triglycerides. These can impact your weight and cause some increases, especially in adolescents taking Zyprexa. If you have concerns, consult with your doctor for a treatment plan catered to you and your needs.

Can I drink alcohol while taking Zyprexa?

You should avoid drinking large amounts of alcohol while using Zyprexa because it can cause an increase in adverse effects. Alcohol can also decrease the benefits of this medication.



Additional information

Brand Name:


Scientific Name:


Other Names:

Olan, Olanzapine, Oleanz, Oliza, Zyprexa


2.5mg, 5mg, 7.5mg, 10mg, 15mg, 20mg

Quantities Available:

28, 84, 100


Film Coated Tablet, Tablet