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Stalevo 150 is a combination medicine used to treat symptoms of Parkinson’s disease, such as muscle stiffness, tremors, spasms, and poor muscle control. It contains three active ingredients: carbidopa, entacapone, and levodopa.

Use and Dosage

Take this medication by mouth with or without food as directed by your doctor, usually 3 to 4 times a day. Take only one tablet for each dose. Swallow the tablet whole. Do not crush, chew, or split the tablet. Doing so may cause you to get the wrong dose and may also cause staining of the mouth, dentures, and saliva.

Taking this medication with food may help to decrease nausea. It is best to avoid a high-protein diet (it decreases the amount of levodopa that your body takes in) during treatment, unless directed otherwise by your doctor. Also avoid taking this medication with a high-fat, high-calorie meal since this can slow down the time it begins to work by about 2 hours.

Separate your dose of this medication by as many hours as possible from any iron supplements or products containing iron (such as multivitamins with minerals) you may take. Iron can reduce the amount of this medication absorbed by the body. Consult your doctor or pharmacist for more details.

The dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this medication is suddenly stopped. Also, if you suddenly stop using this medication, you may have withdrawal symptoms (such as anxiety, depression, confusion, fever, muscle stiffness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used this medication for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stalevo 150 may cause serious side effects:

  • Worsening symptoms such as tremors, twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs
  • Depressed mood, thoughts about hurting yourself
  • Hallucinations, unusual behaviors
  • Severe nausea and vomiting
  • Severe or ongoing diarrhea, watery diarrhea
  • Unexplained muscle pain, tenderness, or weakness
  • Light-headed feeling, like you might pass out
  • Fluid build-up in or around the lungs–pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold, clammy skin, anxiety, rapid heartbeats
  • Severe nervous system reaction–very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats

Stalevo 150 may cause you to fall asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets.

Common side effects of Stalevo 150 may include:

  • Involuntary muscle movement
  • Diarrhea
  • Nausea, vomiting, stomach pain
  • Discolored urine
  • Dry mouth

This is not a complete list of side effects and others may occur. 


  • Before taking this medication, tell your doctor or pharmacist if you are allergic to carbidopa, levodopa, or entacapone; or to foscarbidopa or foslevodopa; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
  • Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, glaucoma, breathing problems (such as asthma), heart disease (such as heart attack, irregular heartbeat), kidney disease, stomach/intestinal ulcer, mental/mood disorders (such as depression, schizophrenia), blood disorders, seizures, sleep disorders.
  • This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). See also the Side Effects section.
  • Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
  • During pregnancy, this medication should be used only when needed. Discuss the risks and benefits with your doctor.
  • Levodopa passes into breast milk in small amounts and may affect how much milk you make. It is unknown if carbidopa or entacapone passes into breast milk. Consult your doctor before breast-feeding.

Forms and Strengths

Stalevo 150 is available in the following forms and strengths:

  • Stalevo 150 Tablet:
    • 37.5/150/200 mg
  • Carbidopa/Levodopa/Entacapone Tablet:
    • 37.5/150/200 mg


What happens if I miss a dose?

Take the medicine as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention.

Overdose symptoms may include rapid heartbeats and feeling light-headed.

What should I avoid while taking Stalevo?

Avoid driving or hazardous activity until you know how Stalevo 150 will affect you. Your reactions could be impaired.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid taking iron supplements without your doctor’s advice. Also avoid increasing the amount of protein in your diet (protein sources include meat, eggs, and cheese). Taking iron or eating too much protein can make it harder for your body to digest and absorb Stalevo.

What other drugs will affect Stalevo?

Using Stalevo with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Many drugs can affect Stalevo. This includes prescription and over-the-counter medicines, vitamins, and herbal products.

Not all interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.



Additional information

Other Names:

Stalevo, Syncapone-150



Quantities Available:

50, 100, 300