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Zomig is a headache medication used to treat and relieve symptoms of migraine headaches that have already begun in adults.

Zolmitriptan is a serotonin receptor agonist that binds to various serotonin receptors to increase the release of neuropeptides and narrow the blood vessels in your brain. These actions allow Zomig to treat symptoms of an active migraine by narrowing your brain’s blood vessels and combatting the release of neuropeptides that cause inflammation.

Dosage and Administration

The dose of Zomig that is prescribed will vary depending on the individual and type of migraines being treated. Follow all directions given by your healthcare provider and read packaging instructions carefully to ensure the best therapeutic results during treatment. Do not change your dose without speaking with your healthcare provider.

  • Swallow tablets whole
  • Take with a whole glass of water
  • Use Zomig as soon as you notice symptoms of a migraine
  • If your migraine does not completely improve or if it comes back, take a second tablet 2 hours after your first dose
  • Most adults take 1.25 to 2.5mg once or twice to treat migraine headaches
  • Doses can increase if needed and tolerated
  • Adults should not take more than 5mg in a single dose and should not have more than 10mg within 24 hours
  • Contact your healthcare provider if your migraine does not improve at all
  • Store at room temperature away from children and pets

Side Effects

Zomig may cause you to develop some side effects while affecting the levels of chemicals in your brain and constricting your blood vessels. Talk with your healthcare provider to learn more about any symptoms that you may encounter during treatment.

Common Zomig side effects include:

  • Pain or tightness in your throat or chest
  • Dry mouth, upset stomach
  • Pressure or heaviness in your body
  • Drowsiness, tiredness
  • flushing

Serious Side Effects

Some more serious adverse reactions may occur during treatment with Zomig. Stop taking this medication and call your healthcare provider right away if you develop any of the following symptoms:

  • Tightness in your jaw, neck, throat, or chest
  • Fast or pounding heart, dizziness
  • Sudden and severe stomachache, bloody diarrhea
  • Heart attack symptoms (chest pain or pressure spreading to your jaw or shoulder, nausea, sweating)
  • High serotonin levels (agitation, hallucinations, fever, fast heartbeat, overactive reflexes, nausa, vomiting, diarrhea, loss of coordination, fainting)

Allergic Reactions

Do not take Zomig if you are allergic to zolmitriptan or other triptan medications. Stop using this medication and contact your healthcare provider right away if you notice any of the following signs of an allergic reaction:

  • Hives
  • Difficulty breathing
  • Swelling of face, lips, tongue, or throat


  • Zomig is designed to treat migraine headaches that have already begun and will not help prevent or reduce the frequency of headaches that you experience.
  • You must wait at least 2 hours before taking another Zomig tablet if needed. Do not take any more than 10mg every 24 hours. Using too much headache medication could cause your migraines to worsen.
  • Do not take Zomig if you have any of the following conditions:
    • Coronary heart disease
    • Angina
    • Blood circulation problems
    • Lack of blood to your heart
    • History of heart attack, heart disease, or stroke
    • Wolff-Parkinson-White syndrome
    • Severe or uncontrolled hypertension (high blood pressure)
    • Headache that feels different than your usual migraines
  • To ensure your safety when taking Zomig, tell your healthcare provider if you have ever had any of the following:
    • Heart disease
    • High blood pressure
    • Heart rhythm disorder
    • Epilepsy or seizures
    • Liver or kidney disease
    • Condition requiring you to take cimetidine
    • Coronary heart disease or risk factors for this condition
  • Do not take Zomig if you have used a monoamine oxidase (MAO) inhibitor within the past 14 days because the two medications could react. MAOIs include isocarboxazid, linezolid, methylene blue injection, and others.
  • Avoid driving or performing hazardous tasks before you know how this medication will affect you because it can impair your thinking or reactions.
  • Do not use Zomig within 24 hours of any other migraine medication including the nasal spray version of this medication, almotriptan, eletriptan, frovatriptan, or ergot medications.
  • It is unclear if Zomig will harm an unborn baby. Tell your healthcare provider if you are pregnant or plan to become pregnant while taking this medication to ensure the safety of you and your child.
  • Ask your healthcare provider before breastfeeding while taking Zomig because it may or may not pass into your breastmilk and affect your nursing baby.
  • Some drugs may interact with Zomig and cause adverse reactions. Tell your healthcare provider about all the medications you take, including over the counter medicines, but especially any of the following:
    • Antidepressant medications (citalopram, paroxetine, duloxetine, venlafaxine, and more)
    • Antipsychotic medicines
    • Narcotic medication
    • Medicine used to prevent nausea and vomiting
    • MAOIs (isocarboxazid, methylene blue injection, rasagiline, and more)
    • Other headache medications
    • Ergot medicines (ergotamine, dihydroergotamine, or methylergonovine)
    • Cimetidine
  • Zomig is not an approved method of treatment for anyone under the age of 18.

Form and Strength

This anti-migraine medication is available in tablet form.

  • Zomig tablet strengths:
    • 2.5mg

The 2.5mg Zomig tablets are available in quantities of 6, 12, and 18.


How long does it take for Zomig to take effect?

Zomig is quickly absorbed into your system after your first dose and should start relieving your migraine symptoms within 1 hour. If your headache is not completely relieved or if it comes back, you can take a second dose of Zomig 2 hours after your first one. Follow all instructions given by your healthcare provider for the best results.

How does Zomig make you feel?

Zomig may cause you to develop dry mouth, drowsiness, dizziness, or tingling sensations after taking one or two doses. These are often mild reactions that go away after the medicine wears off. Speak with your healthcare provider for more information or if any of the symptoms last or become worse.



Additional information

Brand Name:


Scientific Name:


Other Names:

Zolmitriptan, Zomig



Quantities Available:

6, 12, 18